CNBL9_ARATH - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CNBL9_ARATH
• UniProt AC: Q9LTB8
• Protein Name: Calcineurin B-like protein 9
• Gene Name: CBL9
• Organism: Arabidopsis thaliana (Mouse-ear cress).
• Sequence Length: 213
• Subcellular Localization: Cell membrane ; Lipid-anchor . Plasma membrane localization abolished by 2-bromopalmitate (2-BP) treatment.
• Protein Description: Acts as a calcium sensor involved in abscisic acid (ABA) signaling and stress-induced ABA biosynthesis pathways. Contributes to the regulation of early stress-related CBF/DREB transcription factors. CBL proteins interact with CIPK serine-threonine protein kinases. Binding of a CBL protein to the regulatory NAF domain of a CIPK protein lead to the activation of the kinase in a calcium-dependent manner. May function as a negative regulator of stress and ABA responses. Mediates the activation of AKT1 by CIPK proteins (CIPK6, CIPK16, and CIPK23) in response to low potassium conditions and in the context of stomatal movement. Involved in the calcium-dependent regulation by CIPK26 of reactive oxygen species production by the NADPH oxidase RBOHF. The CBL9/CIPK3 complex acts in the regulation of abscisic acid response in seed germination..
• Protein Sequence: MGCFHSTAAREFPDHENPVKLASETAFSVSEVEALYELFKSISSSVVDDGLINKEEFQLALFKNRKKENLFANRIFDLFDVKRKGVIDFGDFVRSLNVFHPNASLEEKTDFTFRLYDMDCTGFIERQEVKQMLIALLCESEMKLADDTIEMILDQTFEDADVDRDGKIDKTEWSNFVIKNPSLLKIMTLPYLRDITTTFPSFVFNSEVDEIAT

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Myristoylation	------MGCFHSTAA ------CCCCCCCCC	23.85	18502848
201	Phosphorylation	DITTTFPSFVFNSEV CCCCCCCHHHCCCCC	29.83	18502848

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
201	S	Phosphorylation	Kinase	CIPK23	Q93VD3	Uniprot

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of CNBL9_ARATH !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CNBL9_ARATH !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
CIPKA_ARATH	SIP1	physical	21798944
RGAPX_ARATH	AT5G61530	physical	21798944
CIPKO_ARATH	SOS2	physical	22253446
CIPKN_ARATH	CIPK23	physical	17922773

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.