CIPKN_ARATH - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CIPKN_ARATH
• UniProt AC: Q93VD3
• Protein Name: CBL-interacting serine/threonine-protein kinase 23
• Gene Name: CIPK23
• Organism: Arabidopsis thaliana (Mouse-ear cress).
• Sequence Length: 482
• Subcellular Localization: Cell membrane ; Peripheral membrane protein . Associated to the plasma membrane when associated with AKT1, CBL1 and CBL9.
• Protein Description: CIPK serine-threonine protein kinases interact with CBL proteins. Binding of a CBL protein to the regulatory NAF domain of CIPK protein leads to activation of the kinase in a calcium-dependent manner. Downstream of CBL1, CBL2, CBL3 and CBL9, regulates by phosphorylation the K(+) conductance and uptake of AKT1 in low K(+) condition, in response to calcium signaling and during the stomatal opening regulation by monitoring the turgor pressure in guard cells. In response to low nitrate concentration, phosphorylates NRT1.1, switching it from a low-affinity nitrate transporter to a high-affinity transporter. Confers tolerance to low potassium conditions. Involved in drought sensitivity and leaf transpiration..
• Protein Sequence: MASRTTPSRSTPSRSTPSGSSSGGRTRVGKYELGRTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQIKREISTMKLIKHPNVIRMFEVMASKTKIYFVLEFVTGGELFDKISSNGRLKEDEARKYFQQLINAVDYCHSRGVYHRDLKPENLLLDANGALKVSDFGLSALPQQVREDGLLHTTCGTPNYVAPEVINNKGYDGAKADLWSCGVILFVLMAGYLPFEDSNLTSLYKKIFKAEFTCPPWFSASAKKLIKRILDPNPATRITFAEVIENEWFKKGYKAPKFENADVSLDDVDAIFDDSGESKNLVVERREEGLKTPVTMNAFELISTSQGLNLGSLFEKQMGLVKRKTRFTSKSSANEIVTKIEAAAAPMGFDVKTNNYKMKLTGEKSGRKGQLAVATEVFQVAPSLYMVEMRKSGGDTLEFHKFYKNLTTGLKDIVWKTIDEEKEEGTDGGGTNGAMANRTIAKQST

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
26	Phosphorylation	GSSSGGRTRVGKYEL CCCCCCCCEEEEEEC	32.74	24894044
41	Phosphorylation	GRTLGEGTFAKVKFA CCCCCCCCEEEEEEE	19.00	19880383
176	Phosphorylation	KVSDFGLSALPQQVR EHHHCCCCCCCHHHH	28.30	-
190	Phosphorylation	REDGLLHTTCGTPNY HHCCCEECCCCCCCC	24.61	19880383
191	Phosphorylation	EDGLLHTTCGTPNYV HCCCEECCCCCCCCC	9.74	19880383
194	Phosphorylation	LLHTTCGTPNYVAPE CEECCCCCCCCCCHH	15.54	23572148
433	Phosphorylation	MRKSGGDTLEFHKFY EHHHCCCCEEHHHHH	31.31	25561503

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of CIPKN_ARATH !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of CIPKN_ARATH !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CIPKN_ARATH !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
AKT1_ARATH	KT1	physical	16895985
AKT1_ARATH	KT1	physical	16814720
CNBL9_ARATH	CBL9	physical	16814720
CNBL1_ARATH	CBL1	physical	16814720
PTR7_ARATH	NRT1.1	physical	19766570
CNBL1_ARATH	CBL1	physical	21685179
CNBL9_ARATH	CBL9	physical	21685179
CNBL1_ARATH	CBL1	physical	21798944
CNBL9_ARATH	CBL9	physical	21798944
CNBL1_ARATH	CBL1	physical	22253446
ACT1_ARATH	ACT1	physical	22253446
ACT3_ARATH	ACT1	physical	22253446
AKT1_ARATH	KT1	physical	19509299
AKT1_ARATH	KT1	physical	17898163
CNBL1_ARATH	CBL1	physical	17898163
CNBL2_ARATH	CBL2	physical	17898163
CNBL3_ARATH	CBL3	physical	17898163
CNBL9_ARATH	CBL9	physical	17898163
P2C77_ARATH	ABI2	physical	25943353
CNBL1_ARATH	CBL1	physical	25943353
CIPKN_ARATH	CIPK23	physical	25943353

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.