ACT3_ARATH - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ACT3_ARATH
• UniProt AC: P0CJ47
• Protein Name: Actin-3
• Gene Name: ACT3
• Organism: Arabidopsis thaliana (Mouse-ear cress).
• Sequence Length: 377
• Subcellular Localization: Cytoplasm, cytoskeleton.
• Protein Description: Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells. Essential component of cell cytoskeleton; plays an important role in cytoplasmic streaming, cell shape determination, cell division, organelle movement and extension growth. This is considered as one of the reproductive actins..
• Protein Sequence: MADGEDIQPLVCDNGTGMVKAGFAGDDAPRAVFPSIVGRPRHTGVMVGMGQKDAYVGDEAQSKRGILTLKYPIEHGIVNNWDDMEKIWHHTFYNELRVAPEEHPILLTEAPLNPKANREKMTQIMFETFNAPAMYVAIQAVLSLYASGRTTGIVLDSGDGVSHTVPIYEGYALPHAILRLDLAGRDLTDALMKILTERGYSFTTTAEREIVRDIKEKLCYIALDYEQELETAKTSSSVEKNYELPDGQVITIGSERFRCPEVLYQPSMIGMENAGIHETTYNSIMKCDVDIRKDLYGNIVLSGGTTMFPGIADRMSKEITALAPSSMKIKVVAPPERKYSVWIGGSILASLSTFQQMWIAKAEYDESGPSIVHRKCF

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MADGEDIQP ------CCCCCCCCC	33.25	-
62	Phosphorylation	YVGDEAQSKRGILTL CCCCHHHCCCCEEEE	31.22	30407730
143	Phosphorylation	VAIQAVLSLYASGRT HHHHHHHHHHHCCCC	16.85	29797451
204	Phosphorylation	ERGYSFTTTAEREIV HCCCCCCCCHHHHHH	23.23	30407730
205	Phosphorylation	RGYSFTTTAEREIVR CCCCCCCCHHHHHHH	24.38	30407730
325	Phosphorylation	EITALAPSSMKIKVV HHHEECCCCCEEEEE	37.14	25561503
326	Phosphorylation	ITALAPSSMKIKVVA HHEECCCCCEEEEEC	24.04	25561503

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of ACT3_ARATH !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of ACT3_ARATH !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ACT3_ARATH !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
ACT7_ARATH	ACT7	physical	21798944
ACT2_ARATH	ACT2	physical	21798944
ANXD5_ARATH	ANN5	physical	25019283

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.