AKT1_ARATH - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: AKT1_ARATH
• UniProt AC: Q38998
• Protein Name: Potassium channel AKT1
• Gene Name: AKT1
• Organism: Arabidopsis thaliana (Mouse-ear cress).
• Sequence Length: 857
• Subcellular Localization: Cell membrane ; Multi-pass membrane protein .
• Protein Description: Highly selective inward-rectifying potassium channel that mediate potassium uptake by plant roots in response to low K(+) conditions, by a calcium-, CBL-, and CIPK-dependent pathway. Positively regulated by phosphorylation by CIPK23. Negatively regulated by a kinase-independent regulatory mechanism involving a competing direct binding of CBL10. Involved in the stomatal regulation by monitoring the turgor pressure in guard cells. Assuming opened or closed conformations in response to the voltage difference across the membrane, the channel is activated by hyperpolarization. May interact with the cytoskeleton or with regulatory proteins. [PubMed: 12678562]
• Protein Sequence: MRGGALLCGQVQDEIEQLSRESSHFSLSTGILPSLGARSNRRVKLRRFVVSPYDHKYRIWEAFLVVLVVYTAWVSPFEFGFLRKPRPPLSITDNIVNAFFAIDIIMTFFVGYLDKSTYLIVDDRKQIAFKYLRSWFLLDLVSTIPSEAAMRISSQSYGLFNMLRLWRLRRVGALFARLEKDRNFNYFWVRCAKLVCVTLFAVHCAACFYYLIAARNSNPAKTWIGANVANFLEESLWMRYVTSMYWSITTLTTVGYGDLHPVNTKEMIFDIFYMLFNLGLTAYLIGNMTNLVVHGTSRTRNFRDTIQAASNFAHRNHLPPRLQDQMLAHLCLKYRTDSEGLQQQETLDALPKAIRSSISHFLFYSLMDKVYLFRGVSNDLLFQLVSEMKAEYFPPKEDVILQNEAPTDFYILVNGTADLVDVDTGTESIVREVKAGDIIGEIGVLCYRPQLFTVRTKRLCQLLRMNRTTFLNIIQANVGDGTIIMNNLLQHLKEMNDPVMTNVLLEIENMLARGKMDLPLNLCFAAIREDDLLLHQLLKRGLDPNESDNNGRTPLHIAASKGTLNCVLLLLEYHADPNCRDAEGSVPLWEAMVEGHEKVVKVLLEHGSTIDAGDVGHFACTAAEQGNLKLLKEIVLHGGDVTRPRATGTSALHTAVCEENIEMVKYLLEQGADVNKQDMHGWTPRDLAEQQGHEDIKALFREKLHERRVHIETSSSVPILKTGIRFLGRFTSEPNIRPASREVSFRIRETRARRKTNNFDNSLFGILANQSVPKNGLATVDEGRTGNPVRVTISCAEKDDIAGKLVLLPGSFKELLELGSNKFGIVATKVMNKDNNAEIDDVDVIRDGDHLIFATDS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
731	Phosphorylation	IRFLGRFTSEPNIRP CCHHHHCCCCCCCCC	30.71	30407730
732	Phosphorylation	RFLGRFTSEPNIRPA CHHHHCCCCCCCCCC	48.63	30407730
740	Phosphorylation	EPNIRPASREVSFRI CCCCCCCCCHHHHHH	31.49	30407730
744	Phosphorylation	RPASREVSFRIRETR CCCCCHHHHHHHHHH	12.21	19880383

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of AKT1_ARATH !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of AKT1_ARATH !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of AKT1_ARATH !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
AKT1_ARATH	KT1	physical	12678562
AKT2_ARATH	KT2/3	physical	12678562
KAT1_ARATH	KAT1	physical	15299147
AKT1_ARATH	KT1	physical	15299147
AKT2_ARATH	KT2/3	physical	15299147
CRK10_ARATH	CRK10	physical	22737156
YSL3_ARATH	YSL3	physical	22737156
CNBLA_ARATH	CBL10	physical	23331977
CNBL7_ARATH	CBL7	physical	23331977
CNBL5_ARATH	CBL5	physical	23331977
CNBL9_ARATH	CBL9	physical	22548784
CNBL1_ARATH	CBL1	physical	22548784
CNBL4_ARATH	SOS3	physical	22548784
CIPKN_ARATH	CIPK23	physical	22548784
PMA1_YEAST	PMA1	physical	25713578

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.