AKT2_ARATH - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: AKT2_ARATH
• UniProt AC: Q38898
• Protein Name: Potassium channel AKT2/3
• Gene Name: AKT2
• Organism: Arabidopsis thaliana (Mouse-ear cress).
• Sequence Length: 802
• Subcellular Localization: Endoplasmic reticulum membrane ; Multi-pass membrane protein . Targeted to the cell membrane when interacting with CIPK6 and CBL4.
• Protein Description: Highly selective and weak inward-rectifying potassium channel. Plays a role in both loading and unloading potassium into/from the phloem sap. Seems to control sugar loading into phloem via a voltage-dependent process. Blocked by physiological concentrations of external calcium and by external acidification. May interact with the cytoskeleton or with regulatory proteins. Dephosphorylation by PP2CA not only leads to the inhibition of potassium currents but also to an increase of the voltage-dependence of the channel. Regulated by the CBL4/CIPK6 calcium sensor/protein kinase complex via a kinase interaction-dependent but phosphorylation-independent translocation of the channel to the plasma membrane..
• Protein Sequence: MDLKYSASHCNLSSDMKLRRFHQHRGKGREEEYDASSLSLNNLSKLILPPLGVASYNQNHIRSSGWIISPMDSRYRCWEFYMVLLVAYSAWVYPFEVAFLNSSPKRNLCIADNIVDLFFAVDIVLTFFVAYIDERTQLLVREPKQIAVRYLSTWFLMDVASTIPFDAIGYLITGTSTLNITCNLLGLLRFWRLRRVKHLFTRLEKDIRYSYFWIRCFRLLSVTLFLVHCAGCSYYLIADRYPHQGKTWTDAIPNFTETSLSIRYIAAIYWSITTMTTVGYGDLHASNTIEMVFITVYMLFNLGLTAYLIGNMTNLVVEGTRRTMEFRNSIEAASNFVNRNRLPPRLKDQILAYMCLRFKAESLNQQHLIDQLPKSIYKSICQHLFLPSVEKVYLFKGVSREILLLLVSKMKAEYIPPREDVIMQNEAPDDVYIIVSGEVEIIDSEMERESVLGTLRCGDIFGEVGALCCRPQSYTFQTKSLSQLLRLKTSFLIETMQIKQQDNATMLKNFLQHHKKLSNLDIGDLKAQQNGENTDVVPPNIASNLIAVVTTGNAALLDELLKAKLSPDITDSKGKTPLHVAASRGYEDCVLVLLKHGCNIHIRDVNGNSALWEAIISKHYEIFRILYHFAAISDPHIAGDLLCEAAKQNNVEVMKALLKQGLNVDTEDHHGVTALQVAMAEDQMDMVNLLATNGADVVCVNTHNEFTPLEKLRVVEEEEEEERGRVSIYRGHPLERRERSCNEAGKLILLPPSLDDLKKIAGEKFGFDGSETMVTNEDGAEIDSIEVIRDNDKLYFVVNKII

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
179	N-linked_Glycosylation	ITGTSTLNITCNLLG CCCCCHHHHHHHHHH	27.84	-
254	N-linked_Glycosylation	TWTDAIPNFTETSLS CHHHCCCCCCHHHHH	50.81	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of AKT2_ARATH !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of AKT2_ARATH !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of AKT2_ARATH !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
P2C37_ARATH	PP2CA	physical	12034902
AKT1_ARATH	KT1	physical	12678562
AKT2_ARATH	KT2/3	physical	12678562
AKT2_ARATH	KT2/3	physical	15299147
CDPK1_ARATH	CPK1	physical	22737156
PUP3_ARATH	PUP3	physical	22737156
UBC34_ARATH	UBC34	physical	24833385
PPP7_ARATH	PP7	physical	24833385
CNIH1_ARATH	AT3G12180	physical	24833385
AKT2_ARATH	KT2/3	physical	17085433
KAT2_ARATH	KAT2	physical	17085433

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.