dbPTM

CNBLA_ARATH - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	CNBLA_ARATH
UniProt AC	Q7FRS8
Protein Name	Calcineurin B-like protein 10
Gene Name	CBL10
Organism	Arabidopsis thaliana (Mouse-ear cress).
Sequence Length	256
Subcellular Localization	Vacuole membrane. Endosome. Cell membrane. Exclusively targeted to the tonoplast when interacting with CIPK24 (PubMed:19832944). PubMed:17449811 indicates a cell membrane localization while PubMed:17825054 shows a vacuole membrane and endosome locali
Protein Description	Acts as a calcium sensor. CBL proteins interact with CIPK serine-threonine protein kinases. Binding of a CBL protein to the regulatory NAF domain of a CIPK protein lead to the activation of the kinase in a calcium-dependent manner. Mediates salt tolerance, but only when phosphorylated. Competes with CIPK23 for a direct binding to AKT1, negatively regulating its activity via a protein kinase-independent mechanism..
Protein Sequence	MTTGRPNNILALKISTRSSSLTVGEQFCAVFIPFFAIIDVLVSSVGQCFDCRSTSPRTCQHADLERLARESQFSVNEVEALYELFKKLSCSIIDDGLIHKEELRLALFQAPYGENLFLDRVFDLFDEKKNGVIEFEEFIHALSVFHPYASIQEKTDFAFRLYDLRQTGFIEREEVQQMVSAILLESDMMLSDELLTMIIDKTFADADSDKDGKISKDEWNVYVHKHPSLLKNMTLPYLKDVTTAFPSFIFNTEVED

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference	Orthologous Protein Cluster
247	Phosphorylation	DVTTAFPSFIFNTEV HHHHHCHHHCCCCCC	25.23	22253446

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
247	S	Phosphorylation	Kinase	CIPK24	Q9LDI3	Uniprot

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of CNBLA_ARATH !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of CNBLA_ARATH !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
CIPKO_ARATH	SOS2	physical	19832944
CIPKO_ARATH	SOS2	physical	22253446
AKT1_ARATH	KT1	physical	23331977
CIPKO_ARATH	SOS2	physical	17825054

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of CNBLA_ARATH

Related Literatures of Post-Translational Modification