NPC4_ARATH - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: NPC4_ARATH
• UniProt AC: Q9SRQ7
• Protein Name: Non-specific phospholipase C4
• Gene Name: NPC4
• Organism: Arabidopsis thaliana (Mouse-ear cress).
• Sequence Length: 538
• Subcellular Localization: Cell membrane ; Peripheral membrane protein .
• Protein Description: Non-specific phospholipase C (PLC) which assumes major PLC activity during inorganic phosphate starvation. Substrate preference is phosphatidylcholine (PC), but can also hydrolyze phosphatidylethanolamine (PE) with lower efficiency. Has no activity toward phosphatidic acid (PA). Plays an important role in the supply of both inorganic phosphate and diacylglycerol from membrane-localized phospholipids during phosphate deprivation. May be required for lipid-derived signaling molecules that positively modulate abscisic acid (ABA) response and promote plant tolerance to drought and salt stresses. May be involved in brassinolide-mediated signaling in root development..
• Protein Sequence: MIETTKGGSGSYPIKTIVVLVQENRSFDHTLGWFKELNREIDGVTKSDPKSNTVSSSDTNSLRVVFGDQSQYVNPDPGHSIQDIYEQVFGKPWDSGKPDPNPGHPNMSGFAQNAERNKKGMSSAVMNGFKPNALPVYKELVQNFAICDRWFASVPASTQPNRLYVHSATSHGATSNDKKLLLEGFPQKTIFESLDEAGFSFGIYYQFPPSTLFYRNLRKLKYLTHFHQYGIQFKKDCKEGKLPNYVVVEQRWFDLLSTPANDDHPSHDVSEGQKLVKEVYEALRSSPQWNEILFIITYDEHGGFYDHVPTPVDGVPNPDGILGPPPYNFEFNRLGVRVPTFFISPWIEPGTVIHGPNGPYPRSQYEHSSIPATVKTIFKLKDFLSKRDSWAGTFESVITRDSPRQDCPETLSTPIKLRGTMAKENAQLSEFQEDLVIMAAGLKGDYKNEELIHKLCKETCVADASKYVTNAFEKFLEESRKARDRGCDENDIVYCVDDDDDHVVIPPQSHSEASNAAAQPKTQTSFFNKLFSCFIRHD

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
4	Phosphorylation	----MIETTKGGSGS ----CCCCCCCCCCC		19880383
5	Phosphorylation	---MIETTKGGSGSY ---CCCCCCCCCCCC		19880383
9	Phosphorylation	IETTKGGSGSYPIKT CCCCCCCCCCCEEEE		19880383
11	Phosphorylation	TTKGGSGSYPIKTIV CCCCCCCCCEEEEEE		19880383
12	Phosphorylation	TKGGSGSYPIKTIVV CCCCCCCCEEEEEEE		19880383
45	Phosphorylation	NREIDGVTKSDPKSN HHHCCCCCCCCCCCC		24894044
47	Phosphorylation	EIDGVTKSDPKSNTV HCCCCCCCCCCCCCC		24894044
157	Phosphorylation	WFASVPASTQPNRLY EECCCCCCCCCCEEE		26811356
158	Phosphorylation	FASVPASTQPNRLYV ECCCCCCCCCCEEEE		26811356
402	Phosphorylation	ESVITRDSPRQDCPE EEEECCCCCCCCCCC		23776212

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of NPC4_ARATH !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of NPC4_ARATH !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of NPC4_ARATH !!

Protein-Protein Interaction

Oops, there are no PPI records of NPC4_ARATH !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.