ASHH2_ARATH - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ASHH2_ARATH
• UniProt AC: Q2LAE1
• Protein Name: Histone-lysine N-methyltransferase ASHH2
• Gene Name: ASHH2 {ECO:0000303|PubMed:19915673}
• Organism: Arabidopsis thaliana (Mouse-ear cress).
• Sequence Length: 1759
• Subcellular Localization: Nucleus . Chromosome, centromere . Associates with centromeric constitutive heterochromatin.
• Protein Description: Histone methyltransferase involved in di and tri-methylation of 'Lys-36' of histone H3 (H3K36me2 and H3K36me3). Binds to H3 already mono- or di-methylated on 'Lys-4'(H3K4me1 or H3K4me2), but not to H3K4me3. H3K4me and H3K36me represent specific tags for epigenetic transcriptional activation. Regulates positively FLC transcription to prevent early flowering transition. Required for flowering transition in response to vernalization and for the maintenance of FLC expression in late embryos, but dispensable for the initial reactivation in early embryos during reprogramming. Seems also to modulate several traits including floral organ size, root size and dormancy. Promotes apical dominance. [PubMed: 16299497]
• Protein Sequence: MDCKENGVGDASGCNIDANSLASNLAMNTNEDFYEKLSSRGQNLDSVSSLEIPQTASSVNHTIEGQRKCFTEIEQMGYGNSNSQEDAGNTDDDLYVCYNADDTQEQGVVSGELEQSQELICDTDLLVNCNKLDDGKESQDTNVSLVSIFSGSMQEKEAPQAKEDEGYGGTTLPIGGSGIDTESTFVNDAPEQFESLETTKHIKPDEVESDGISYRFDDGGKEGRNGPSSDLDTGSSDDISLSQSFSFPDSLLDSSVFGCSATESYLEDAIDIEGNGTIVVSPSLAITEMLNNDDGGLCSHDLNKITVTETINPDLKLVREDRLDTDLSVMNEKMLKNHVGDSSSESAVAALSMNNGMAADLRAENFSQSSPIDEKTLDMEANSPITDSSLIWNFPLNFGSGGIEVCNPENAVEPLRIVDDNGRIGGEVASASGSDFCEAGMSSSRRKARDGKQCKVVQTKTSARHLRKSSRKKQSERDIESIFKCSKQKRSSLLKTSRSSEWGLPSKTTEIFLQSNNIPYDGPPHHEPQRSQGNLNNGEHNRSSHNGNVEGSNRNIQASSGSCLRLKVKFGKSGGQNPLNITVSKVSGNSLPGNGIVKAGTCLELPGSAHFGEDKMQTVETKEDLVEKSNPVEKVSYLQSSDSMRDKKYNQDAGGLCRKVGGDVLDDDPHLSSIRMVEECERATGTQSLDAETSPDSEVINSVPDSIVNIEHKEGLHHGFFSTPEDVVKKNRVLEKEDELRASKSPSENGSHLIPNAKKAKHPKSKSNGTKKGKSKFSESAKDGRKNESHEGVEQRKSLNTSMGRDDSDYPEVGRIESHKTTGALLDADIGKTSATYGTISSDVTHGEMVVDVTIEDSYSTESAWVRCDDCFKWRRIPASVVGSIDESSRWICMNNSDKRFADCSKSQEMSNEEINEELGIGQDEADAYDCDAAKRGKEKEQKSKRLTGKQKACFKAIKTNQFLHRNRKSQTIDEIMVCHCKPSPDGRLGCGEECLNRMLNIECLQGTCPAGDLCSNQQFQKRKYVKFERFQSGKKGYGLRLLEDVREGQFLIEYVGEVLDMQSYETRQKEYAFKGQKHFYFMTLNGNEVIDAGAKGNLGRFINHSCEPNCRTEKWMVNGEICVGIFSMQDLKKGQELTFDYNYVRVFGAAAKKCYCGSSHCRGYIGGDPLNGDVIIQSDSDEEYPELVILDDDESGEGILGATSRTFTDDADEQMPQSFEKVNGYKDLAPDNTQTQSSVSVKLPEREIPPPLLQPTEVLKELSSGISITAVQQEVPAEKKTKSTSPTSSSLSRMSPGGTNSDKTTKHGSGEDKKILPRPRPRMKTSRSSESSKRDKGGIYPGVNKAQVIPVNKLQQQPIKSKGSEKVSPSIETFEGKLNELLDAVGGISKRRDSAKGYLKLLLLTAASRGTDEEGIYSNRDLSMILDALLKTKSKSVLVDIINKNGPFAGMESFKDSVLSFTEHDDYTVHNIARSFRDRWIPKHFRKPWRINREERSESMRSPINRRFRASQEPRYDHQSPRPAEPAASVTSSKAATPETASVSEGYSEPNSGLPETNGRKRKSRWDQPSKTKEQRIMTILSQQTDETNGNQDVQDDLPPGFSSPCTDVPDAITAQPQQKFLSRLPVSYGIPLSIVHQFGSPGKEDPTTWSVAPGMPFYPFPPLPPVSHGEFFAKRNVRACSSSMGNLTYSNEILPATPVTDSTAPTRKRELFSSDIGTTYFRQQKQSVPPWLRNNGGEKTANSPIPGNLTLEKKLNS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
209	Phosphorylation	IKPDEVESDGISYRF CCCCCEECCCEEEEE	46.44	30291188
213	Phosphorylation	EVESDGISYRFDDGG CEECCCEEEEECCCC	18.78	23660473
214	Phosphorylation	VESDGISYRFDDGGK EECCCEEEEECCCCC	17.24	23660473
328	Phosphorylation	DRLDTDLSVMNEKML CCCCCCHHHHCHHHH	23.33	27643528
367	Phosphorylation	DLRAENFSQSSPIDE HHHHHCCCCCCCCCH	40.51	30407730
369	Phosphorylation	RAENFSQSSPIDEKT HHHCCCCCCCCCHHH	36.56	19880383
370	Phosphorylation	AENFSQSSPIDEKTL HHCCCCCCCCCHHHC	20.45	19880383
1239	Phosphorylation	DNTQTQSSVSVKLPE CCCCCCCEEEEECCC	14.48	28011693
1241	Phosphorylation	TQTQSSVSVKLPERE CCCCCEEEEECCCCC	18.58	28011693
1284	Phosphorylation	PAEKKTKSTSPTSSS CCCCCCCCCCCCCHH	39.07	23776212
1285	Phosphorylation	AEKKTKSTSPTSSSL CCCCCCCCCCCCHHH	40.04	23776212
1286	Phosphorylation	EKKTKSTSPTSSSLS CCCCCCCCCCCHHHC	33.02	23776212
1288	Phosphorylation	KTKSTSPTSSSLSRM CCCCCCCCCHHHCCC	40.79	23776212
1289	Phosphorylation	TKSTSPTSSSLSRMS CCCCCCCCHHHCCCC	22.70	23776212
1290	Phosphorylation	KSTSPTSSSLSRMSP CCCCCCCHHHCCCCC	37.46	23776212
1291	Phosphorylation	STSPTSSSLSRMSPG CCCCCCHHHCCCCCC	30.08	23776212
1293	Phosphorylation	SPTSSSLSRMSPGGT CCCCHHHCCCCCCCC	28.08	23776212
1296	Phosphorylation	SSSLSRMSPGGTNSD CHHHCCCCCCCCCCC	21.20	25561503
1503	Phosphorylation	ERSESMRSPINRRFR HHCHHHCCHHHHHHH	22.84	29654922
1512	Phosphorylation	INRRFRASQEPRYDH HHHHHHHCCCCCCCC	30.71	29654922
1517	Phosphorylation	RASQEPRYDHQSPRP HHCCCCCCCCCCCCC	28.61	25561503
1521	Phosphorylation	EPRYDHQSPRPAEPA CCCCCCCCCCCCCCC	21.32	25561503

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of ASHH2_ARATH !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of ASHH2_ARATH !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ASHH2_ARATH !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
ASHH1_ARATH	SDG26	physical	22438063
ASHH2_ARATH	EFS	physical	22438063
ATX1_ARATH	ATX1	physical	22438063
H33_HUMAN	H3F3A	physical	18070919
BZR2_ARATH	BES1	physical	24838002

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.