ASHH1_ARATH - dbPTM
ASHH1_ARATH - PTM Information in dbPTM
Basic Information of Protein
UniProt ID ASHH1_ARATH
UniProt AC Q84WW6
Protein Name Histone-lysine N-methyltransferase ASHH1 {ECO:0000305}
Gene Name ASHH1
Organism Arabidopsis thaliana (Mouse-ear cress).
Sequence Length 492
Subcellular Localization Nucleus. Chromosome, centromere. Associates with centromeric constitutive heterochromatin..
Protein Description Histone methyltransferase involved in regulation of flowering time. Required for the expression of the SOC1/AGL20 gene. Required for histone H3 trimethylation on 'Lys-4' (H3K4me3) at the SOC1 locus. Prevents trimethylation on 'Lys-27' (H3K27me3) at the same locus..
Protein Sequence MQFSCDPDQEGDELPQYEHIYQNDFSYRKHKKQKEEDISICECKFDFGDPDSACGERCLNVITNTECTPGYCPCGVYCKNQKFQKCEYAKTKLIKCEGRGWGLVALEEIKAGQFIMEYCGEVISWKEAKKRAQTYETHGVKDAYIISLNASEAIDATKKGSLARFINHSCRPNCETRKWNVLGEVRVGIFAKESISPRTELAYDYNFEWYGGAKVRCLCGAVACSGFLGAKSRGFQEDTYVWEDGDDRYSVDKIPVYDSAEDELTSEPSKNGESNTNEEKEKDISTENHLESTALNIQQQSDSTPTPMEEDVVTETVKTETSEDMKLLSQNSQEDSSPKTAIVSRVHGNISKIKSESLPKKRGRPFSGGKTKNVAQKHVDIANVVQLLATKEAQDEVLKYEEVKKEAAVRLSSLYDEIRPAIEEHERDSQDSVATSVAEKWIQASCNKLKAEFDLYSSVIKNIASTPIKPQDTKTKVAEAGNEDHIKLLEAK
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure
ASA (%) Reference Orthologous
Protein Cluster
194PhosphorylationVGIFAKESISPRTEL
EEEEECCCCCCCCEE
27.8819880383
196PhosphorylationIFAKESISPRTELAY
EEECCCCCCCCEEEE
20.0119880383
257PhosphorylationSVDKIPVYDSAEDEL
EEEEECCCCCCCCHH
9.9923776212
259PhosphorylationDKIPVYDSAEDELTS
EEECCCCCCCCHHCC
18.8323776212
332PhosphorylationMKLLSQNSQEDSSPK
HHHHHHCCCCCCCCC
27.5823776212
336PhosphorylationSQNSQEDSSPKTAIV
HHCCCCCCCCCHHHH
48.0323776212
337PhosphorylationQNSQEDSSPKTAIVS
HCCCCCCCCCHHHHE
42.6223776212

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of ASHH1_ARATH !!

Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of ASHH1_ARATH !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10)
Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of ASHH1_ARATH !!

Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
ASHH1_ARATHSDG26physical
22438063
ASHH2_ARATHEFSphysical
22438063
ATX1_ARATHATX1physical
22438063
H4_HUMANHIST1H4Iphysical
18070919

Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of ASHH1_ARATH

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Related Literatures of Post-Translational Modification

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