ASHH1_ARATH - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ASHH1_ARATH
• UniProt AC: Q84WW6
• Protein Name: Histone-lysine N-methyltransferase ASHH1 {ECO:0000305}
• Gene Name: ASHH1
• Organism: Arabidopsis thaliana (Mouse-ear cress).
• Sequence Length: 492
• Subcellular Localization: Nucleus. Chromosome, centromere. Associates with centromeric constitutive heterochromatin..
• Protein Description: Histone methyltransferase involved in regulation of flowering time. Required for the expression of the SOC1/AGL20 gene. Required for histone H3 trimethylation on 'Lys-4' (H3K4me3) at the SOC1 locus. Prevents trimethylation on 'Lys-27' (H3K27me3) at the same locus..
• Protein Sequence: MQFSCDPDQEGDELPQYEHIYQNDFSYRKHKKQKEEDISICECKFDFGDPDSACGERCLNVITNTECTPGYCPCGVYCKNQKFQKCEYAKTKLIKCEGRGWGLVALEEIKAGQFIMEYCGEVISWKEAKKRAQTYETHGVKDAYIISLNASEAIDATKKGSLARFINHSCRPNCETRKWNVLGEVRVGIFAKESISPRTELAYDYNFEWYGGAKVRCLCGAVACSGFLGAKSRGFQEDTYVWEDGDDRYSVDKIPVYDSAEDELTSEPSKNGESNTNEEKEKDISTENHLESTALNIQQQSDSTPTPMEEDVVTETVKTETSEDMKLLSQNSQEDSSPKTAIVSRVHGNISKIKSESLPKKRGRPFSGGKTKNVAQKHVDIANVVQLLATKEAQDEVLKYEEVKKEAAVRLSSLYDEIRPAIEEHERDSQDSVATSVAEKWIQASCNKLKAEFDLYSSVIKNIASTPIKPQDTKTKVAEAGNEDHIKLLEAK

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
194	Phosphorylation	VGIFAKESISPRTEL EEEEECCCCCCCCEE	27.88	19880383
196	Phosphorylation	IFAKESISPRTELAY EEECCCCCCCCEEEE	20.01	19880383
257	Phosphorylation	SVDKIPVYDSAEDEL EEEEECCCCCCCCHH	9.99	23776212
259	Phosphorylation	DKIPVYDSAEDELTS EEECCCCCCCCHHCC	18.83	23776212
332	Phosphorylation	MKLLSQNSQEDSSPK HHHHHHCCCCCCCCC	27.58	23776212
336	Phosphorylation	SQNSQEDSSPKTAIV HHCCCCCCCCCHHHH	48.03	23776212
337	Phosphorylation	QNSQEDSSPKTAIVS HCCCCCCCCCHHHHE	42.62	23776212

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of ASHH1_ARATH !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of ASHH1_ARATH !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ASHH1_ARATH !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
ASHH1_ARATH	SDG26	physical	22438063
ASHH2_ARATH	EFS	physical	22438063
ATX1_ARATH	ATX1	physical	22438063
H4_HUMAN	HIST1H4I	physical	18070919

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.