APRR5_ARATH - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: APRR5_ARATH
• UniProt AC: Q6LA42
• Protein Name: Two-component response regulator-like APRR5
• Gene Name: APRR5
• Organism: Arabidopsis thaliana (Mouse-ear cress).
• Sequence Length: 558
• Subcellular Localization: Nucleus .
• Protein Description: Transcriptional repressor of CCA1 and LHY, thereby controlling photoperiodic flowering response. Involved in the positive and negative feedback loops of the circadian clock. Expression of several members of the ARR-like family is controlled by circadian rhythm. Proteolytic substrate of the E3 ubiquitin ligase SCF(ADO1) complex. APRR9, APRR7, and APRR5 coordinately act on the upstream region of the target genes to repress their expression from noon until midnight. The particular coordinated sequential expression of APRR9, APRR7, APRR5, APRR3 and APPR1 result to circadian waves that may be at the basis of the endogenous circadian clock. Negative regulator of shade avoidance response. Involved in the inhibition of leaf expansion in shade avoidance response..
• Protein Sequence: MTSSEEVVEVTVVKAPEAGGGKLSRRKIRKKDAGVDGLVKWERFLPKIALRVLLVEADDSTRQIIAALLRKCSYRVAAVPDGLKAWEMLKGKPESVDLILTEVDLPSISGYALLTLIMEHDICKNIPVIMMSTQDSVNTVYKCMLKGAADYLVKPLRRNELRNLWQHVWRRQTSLAPDSFPWNESVGQQKAEGASANNSNGKRDDHVVSGNGGDAQSSCTRPEMEGESADVEVSARDAVQMECAKSQFNETRLLANELQSKQAEAIDFMGASFRRTGRRNREESVAQYESRIELDLSLRRPNASENQSSGDRPSLHPSSASAFTRYVHRPLQTQCSASPVVTDQRKNVAASQDDNIVLMNQYNTSEPPPNAPRRNDTSFYTGADSPGPPFSNQLNSWPGQSSYPTPTPINNIQFRDPNTAYTSAMAPASLSPSPSSVSPHEYSSMFHPFNSKPEGLQDRDCSMDVDERRYVSSATEHSAIGNHIDQLIEKKNEDGYSLSVGKIQQSLQREAALTKFRMKRKDRCYEKKVRYESRKKLAEQRPRIKGQFVRQVQSTQAP

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
185	Phosphorylation	DSFPWNESVGQQKAE CCCCCCCCCCCHHHH	28.47	30291188
195	Phosphorylation	QQKAEGASANNSNGK CHHHHCCCCCCCCCC	42.24	25561503
199	Phosphorylation	EGASANNSNGKRDDH HCCCCCCCCCCCCCC	46.93	25561503
499	Phosphorylation	NEDGYSLSVGKIQQS CCCCCCCCHHHHHHH	23.92	17586839

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of APRR5_ARATH !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of APRR5_ARATH !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of APRR5_ARATH !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
ADO1_ARATH	ZTL	physical	15310821
ADO2_ARATH	LKP2	physical	15310821
ADO3_ARATH	FKF1	physical	15310821
WNK1_ARATH	WNK1	physical	12506983
WNK4_ARATH	WNK4	physical	12506983
WNK1_ARATH	WNK1	physical	12091722
APRR9_ARATH	PRR9	genetic	15767265
APRR7_ARATH	PRR7	genetic	15767265
APRR1_ARATH	TOC1	genetic	18178585
APRR7_ARATH	PRR7	genetic	17519251
LHY_ARATH	LHY	genetic	17519251
CCA1_ARATH	CCA1	genetic	17519251
APRR7_ARATH	PRR7	genetic	17504813
LHY_ARATH	LHY	genetic	17504813
CCA1_ARATH	CCA1	genetic	17504813
ADO1_ARATH	ZTL	physical	17693530
APRR7_ARATH	PRR7	genetic	15695441
APRR9_ARATH	PRR9	genetic	12955513
ADO1_ARATH	ZTL	physical	18562312
APRR1_ARATH	TOC1	physical	20407420
TPL_ARATH	TPL	physical	23267111

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Temporal analysis of sucrose-induced phosphorylation changes inplasma membrane proteins of Arabidopsis.";
Niittylae T., Fuglsang A.T., Palmgren M.G., Frommer W.B.,Schulze W.X.;
Mol. Cell. Proteomics 6:1711-1726(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-499, AND MASSSPECTROMETRY.
PubMed: 17586839