ADO2_ARATH - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ADO2_ARATH
• UniProt AC: Q8W420
• Protein Name: Adagio protein 2
• Gene Name: ADO2
• Organism: Arabidopsis thaliana (Mouse-ear cress).
• Sequence Length: 611
• Subcellular Localization: Nucleus. Cytoplasm.
• Protein Description: Component of an E3 ubiquitin ligase complex that plays a central role in blue light-dependent circadian cycles. Acts as a blue light photoreceptor, due to the presence of FMN, that mediates light-regulated protein degradation of critical clock components by targeting them to the proteasome complex. The SCF(ADO2) E3 ubiquitin ligase complex is involved in the regulation of circadian clock-dependent processes including the transition to flowering time, hypocotyl elongation, cotyledons and leaf movement rhythms. APRR1/TOC1 and APRR5 seem to be substrates of the SCF(ADO2) complex. ADO2 interacts with ADO3 and export it to cytoplasmic speckles, preventing the interaction of ADO3 with CDF1. Ubiquitination of ADO2 is not involved in this recruitment..
• Protein Sequence: MQNQMEWDSDSDLSGGDEVAEDGWFGGDNGAIPFPVGSLPGTAPCGFVVSDALEPDNPIIYVNTVFEIVTGYRAEEVIGRNCRFLQCRGPFTKRRHPMVDSTIVAKMRQCLENGIEFQGELLNFRKDGSPLMNKLRLVPIREEDEITHFIGVLLFTDAKIDLGPSPDLSAKEIPRISRSFTSALPIGERNVSRGLCGIFELSDEVIAIKILSQLTPGDIASVGCVCRRLNELTKNDDVWRMVCQNTWGTEATRVLESVPGAKRIGWVRLAREFTTHEATAWRKFSVGGTVEPSRCNFSACAVGNRIVIFGGEGVNMQPMNDTFVLDLGSSSPEWKSVLVSSPPPGRWGHTLSCVNGSRLVVFGGYGSHGLLNDVFLLDLDADPPSWREVSGLAPPIPRSWHSSCTLDGTKLIVSGGCADSGALLSDTFLLDLSMDIPAWREIPVPWTPPSRLGHTLTVYGDRKILMFGGLAKNGTLRFRSNDVYTMDLSEDEPSWRPVIGYGSSLPGGMAAPPPRLDHVAISLPGGRILIFGGSVAGLDSASQLYLLDPNEEKPAWRILNVQGGPPRFAWGHTTCVVGGTRLVVLGGQTGEEWMLNEAHELLLATSTTAST

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
82	Other	EEVIGRNCRFLQCRG HHHHCCCCCEEEECC	2.91	-
82	Other	EEVIGRNCRFLQCRG HHHHCCCCCEEEECC	2.91	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of ADO2_ARATH !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of ADO2_ARATH !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ADO2_ARATH !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
ADO2_ARATH	LKP2	physical	15310821
ADO1_ARATH	ZTL	physical	15310821
ADO3_ARATH	FKF1	physical	15310821
GIGAN_ARATH	GI	physical	17704763
DI191_ARATH	DI19	physical	15937324
CONS_ARATH	CO	physical	15937324
COL1_ARATH	COL1	physical	15937324
COL2_ARATH	COL2	physical	15937324
COL3_ARATH	COL3	physical	15937324
COL4_ARATH	COL4	physical	15937324
COL5_ARATH	COL5	physical	15937324
COL13_ARATH	AT2G47890	physical	15937324
COL14_ARATH	AT2G33500	physical	15937324
CDF2_ARATH	CDF2	physical	16002617
CDF3_ARATH	CDF3	physical	16002617
CDF1_ARATH	CDF1	physical	16002617
APRR5_ARATH	PRR5	physical	20354196
APRR1_ARATH	TOC1	physical	20354196
ADO3_ARATH	FKF1	physical	21518052

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.