APRR1_ARATH - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: APRR1_ARATH
• UniProt AC: Q9LKL2
• Protein Name: Two-component response regulator-like APRR1
• Gene Name: APRR1
• Organism: Arabidopsis thaliana (Mouse-ear cress).
• Sequence Length: 618
• Subcellular Localization: Nucleus .
• Protein Description: Controls photoperiodic flowering response. Component of the circadian clock. Expression of several members of the ARR-like family is controlled by circadian rhythm. The particular coordinated sequential expression of APRR9, APRR7, APRR5, APRR3 and APPR1 result to circadian waves that may be at the basis of the endogenous circadian clock. Positive regulator of CCA1 and LHY expression..
• Protein Sequence: MDLNGECKGGDGFIDRSRVRILLCDNDSTSLGEVFTLLSECSYQVTAVKSARQVIDALNAEGPDIDIILAEIDLPMAKGMKMLRYITRDKDLRRIPVIMMSRQDEVPVVVKCLKLGAADYLVKPLRTNELLNLWTHMWRRRRMLGLAEKNMLSYDFDLVGSDQSDPNTNSTNLFSDDTDDRSLRSTNPQRGNLSHQENEWSVATAPVHARDGGLGADGTATSSLAVTAIEPPLDHLAGSHHEPMKRNSNPAQFSSAPKKSRLKIGESSAFFTYVKSTVLRTNGQDPPLVDGNGSLHLHRGLAEKFQVVASEGINNTKQARRATPKSTVLRTNGQDPPLVNGNGSHHLHRGAAEKFQVVASEGINNTKQAHRSRGTEQYHSQGETLQNGASYPHSLERSRTLPTSMESHGRNYQEGNMNIPQVAMNRSKDSSQVDGSGFSAPNAYPYYMHGVMNQVMMQSAAMMPQYGHQIPHCQPNHPNGMTGYPYYHHPMNTSLQHSQMSLQNGQMSMVHHSWSPAGNPPSNEVRVNKLDRREEALLKFRRKRNQRCFDKKIRYVNRKRLAERRPRVKGQFVRKMNGVNVDLNGQPDSADYDDEEEEEEEEEEENRDSSPQDDALGT

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
194	Phosphorylation	NPQRGNLSHQENEWS CCCCCCCCCCCCCCE	27.42	30291188
267	Phosphorylation	SRLKIGESSAFFTYV CCCCCCCCHHHHHHH	23.04	19880383
268	Phosphorylation	RLKIGESSAFFTYVK CCCCCCCHHHHHHHE	25.45	19880383
273	Phosphorylation	ESSAFFTYVKSTVLR CCHHHHHHHEEEEEE	10.75	19880383
398	Phosphorylation	YPHSLERSRTLPTSM CCCHHCCCCCCCCCH	21.90	24894044

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
-	K	Ubiquitination	E3 ubiquitin ligase	ADO1	Q94BT6	PMID:22199232

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of APRR1_ARATH !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of APRR1_ARATH !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
PIF4_ARATH	PIF4	physical	14634162
PIF5_ARATH	PIL6	physical	14634162
APRR1_ARATH	TOC1	physical	14634162
APRR9_ARATH	PRR9	physical	14634162
ADO1_ARATH	ZTL	physical	15310821
ADO2_ARATH	LKP2	physical	15310821
ADO3_ARATH	FKF1	physical	15310821
APRR3_ARATH	PRR3	physical	18055606
ADO1_ARATH	ZTL	physical	16428597
ADO1_ARATH	ZTL	physical	14654842
ADO3_ARATH	FKF1	physical	14654842
ADO2_ARATH	LKP2	physical	14654842
PIF5_ARATH	PIL6	physical	15356333
PIF3_ARATH	PIF3	physical	15356333
PIL1_ARATH	PIL1	physical	12826627
PIF6_ARATH	PIL2	physical	12826627
PIF3_ARATH	PIF3	physical	12826627
PIF1_ARATH	PIL5	physical	12826627
PIF4_ARATH	PIF4	physical	12826627
PIF5_ARATH	PIL6	physical	12826627
PIL1_ARATH	PIL1	physical	11828023
PIF3_ARATH	PIF3	physical	11828023
CCA1_ARATH	CCA1	genetic	17483414
GIGAN_ARATH	GI	genetic	17098855
APRR5_ARATH	PRR5	genetic	18178585
CCA1_ARATH	CCA1	genetic	17540692
TIC_ARATH	TIC	genetic	17496120
ADO1_ARATH	ZTL	physical	18562312
APRR3_ARATH	PRR3	physical	18562312
APRR5_ARATH	PRR5	physical	20407420
ADO1_ARATH	ZTL	physical	20407420
TCP21_ARATH	AT5G08330	physical	19286557
ELF3_ARATH	ELF3	physical	26545401

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.