ADO1_ARATH - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ADO1_ARATH
• UniProt AC: Q94BT6
• Protein Name: Adagio protein 1
• Gene Name: ADO1
• Organism: Arabidopsis thaliana (Mouse-ear cress).
• Sequence Length: 609
• Subcellular Localization: Nucleus. Cytoplasm. Nuclear after 9 hours of illumination (afternoon of long days). Cytoplasmic when plant have been subsequently grown 16 hours in light and 5 hours in dark (early morning of long days).
• Protein Description: Component of an E3 ubiquitin ligase complex that plays a central role in blue light-dependent circadian cycles. Acts as a blue light photoreceptor, due to the presence of FMN, that mediates light-regulated protein degradation of critical clock components by targeting them to the proteasome complex. The SCF(ADO1) E3 ubiquitin ligase complex is involved in the regulation of circadian clock-dependent processes including the transition to flowering time, hypocotyl elongation, cotyledons and leaf movement rhythms. APRR1/TOC1 and APRR5, but not 'GIGANTEA', are proteolytic substrates of this ubiquitin ligase complex. Blue light enhances cooperative stabilization of 'GIGANTEA' and ADO1/ZTL, leading to amplification and sharpening of the expression profile of APRR1/TOC1. ADO1/ZTL interacts with ADO3, preventing the interaction of ADO3 with CDF1..
• Protein Sequence: MEWDSGSDLSADDASSLADDEEGGLFPGGGPIPYPVGNLLHTAPCGFVVTDAVEPDQPIIYVNTVFEMVTGYRAEEVLGGNCRFLQCRGPFAKRRHPLVDSMVVSEIRKCIDEGIEFQGELLNFRKDGSPLMNRLRLTPIYGDDDTITHIIGIQFFIETDIDLGPVLGSSTKEKSIDGIYSALAAGERNVSRGMCGLFQLSDEVVSMKILSRLTPRDVASVSSVCRRLYVLTKNEDLWRRVCQNAWGSETTRVLETVPGAKRLGWGRLARELTTLEAAAWRKLSVGGSVEPSRCNFSACAVGNRVVLFGGEGVNMQPMNDTFVLDLNSDYPEWQHVKVSSPPPGRWGHTLTCVNGSNLVVFGGCGQQGLLNDVFVLNLDAKPPTWREISGLAPPLPRSWHSSCTLDGTKLIVSGGCADSGVLLSDTFLLDLSIEKPVWREIPAAWTPPSRLGHTLSVYGGRKILMFGGLAKSGPLKFRSSDVFTMDLSEEEPCWRCVTGSGMPGAGNPGGVAPPPRLDHVAVNLPGGRILIFGGSVAGLHSASQLYLLDPTEDKPTWRILNIPGRPPRFAWGHGTCVVGGTRAIVLGGQTGEEWMLSELHELSLASYLT

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
82	Other	EEVLGGNCRFLQCRG HHHHCCCCEEEEECC	3.53	-
82	Other	EEVLGGNCRFLQCRG HHHHCCCCEEEEECC	3.53	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of ADO1_ARATH !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of ADO1_ARATH !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ADO1_ARATH !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
GIGAN_ARATH	GI	physical	17704763
APRR1_ARATH	TOC1	physical	17704763
PHYB_ARATH	PHYB	physical	16428597
APRR1_ARATH	TOC1	physical	14654842
APRR5_ARATH	PRR5	physical	17693530
APRR5_ARATH	PRR5	genetic	17693530
DI191_ARATH	DI19	physical	15937324
CUL1_ARATH	CUL1	physical	15447654
RBX1A_ARATH	RBX1	physical	15447654
PHYB_ARATH	PHYB	physical	11260718
CRY1_ARATH	CRY1	physical	11260718
ELF3_ARATH	ELF3	genetic	16258016
APRR5_ARATH	PRR5	physical	18562312
APRR1_ARATH	TOC1	physical	18562312
SKP1A_ARATH	SKP1	physical	12795696
SKP1B_ARATH	ASK2	physical	12795696
ASK11_ARATH	SK11	physical	12795696
ASK12_ARATH	SK12	physical	12795696
ASK4_ARATH	SK4	physical	12795696
ASK3_ARATH	SK3	physical	12795696
ASK9_ARATH	SK9	physical	12795696
ASK7_ARATH	SK7	physical	12795696
ASK8_ARATH	SK8	physical	12795696
ASK19_ARATH	SK19	physical	12795696
APRR5_ARATH	PRR5	physical	20354196
APRR1_ARATH	TOC1	physical	20354196
ADO3_ARATH	FKF1	physical	21518052
SKP1A_ARATH	SKP1	physical	15447654
SKP1A_ARATH	SKP1	physical	16428597

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.