WNK4_ARATH - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: WNK4_ARATH
• UniProt AC: Q9LVL5
• Protein Name: Probable serine/threonine-protein kinase WNK4
• Gene Name: WNK4
• Organism: Arabidopsis thaliana (Mouse-ear cress).
• Sequence Length: 571
• Protein Description: May regulate flowering time by modulating the photoperiod pathway..
• Protein Sequence: MNMNQVAEYVETDPTGRYGRFAEILGRGAMKTVYKAIDEKLGIEVAWSQVKLKEVLRSSVDLQRLYSEVHLLSTLNHKSIIRFYTSWIDVHNHTLNFITELFTSGTLRQYKNKYLRIDIRAIKSWARQILEGLVYLHEHDPPVIHRDLKCDNIFVNGHLGQVKIGDLGLARMLRDCHSAHSIIGTPEFMAPELYEENYNELIDVYSFGMCFLEMITSEFPYSECNHPAQIYKKVVGGKLPGAFYRVGDIEAQRFIGKCLVSASKRVSAKELLQDPFLASDESWMVYTSGAGNPKPFLNENEMDTLKLEDDELRTEMSIAGKLGAEDNKIDLEVQIAYDNGLANNVFFPFDIMNDTSIDVAKEMVKELEIIDWEPVEIAKMIDGAISSLVSDWKYEEDDETPHDHHRHRTDSFHSSSSHASSSQASLSNYMARGLQDWVQDDLHDETYSQSSSHSGSYSNLNYIAVDEYSSQSPVMSRTHNMTRFCPEESSHLQSGQANAYAASSSTNRSLASDNRTLTRNRSLVDVQRQLLHRSPGEEARKRRLFKTVGDVETVGFQSPYAVSRKPPSSRR

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
522	Phosphorylation	RTLTRNRSLVDVQRQ CCCCCCHHHHHHHHH	35.97	19880383
547	Phosphorylation	RKRRLFKTVGDVETV HHHHHHCCCCCCEEC	23.53	30589143
558	Phosphorylation	VETVGFQSPYAVSRK CEECCCCCCCHHCCC	20.02	30589143
563	Phosphorylation	FQSPYAVSRKPPSSR CCCCCHHCCCCCCCC	26.81	30407730

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of WNK4_ARATH !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of WNK4_ARATH !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of WNK4_ARATH !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
WNK4_ARATH	WNK4	physical	25969537

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Large-scale Arabidopsis phosphoproteome profiling reveals novelchloroplast kinase substrates and phosphorylation networks.";
Reiland S., Messerli G., Baerenfaller K., Gerrits B., Endler A.,Grossmann J., Gruissem W., Baginsky S.;
Plant Physiol. 150:889-903(2009).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-522, AND MASSSPECTROMETRY.
PubMed: 19376835

"Phosphoproteomic analysis of nuclei-enriched fractions fromArabidopsis thaliana.";
Jones A.M.E., MacLean D., Studholme D.J., Serna-Sanz A.,Andreasson E., Rathjen J.P., Peck S.C.;
J. Proteomics 72:439-451(2009).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-522, AND MASSSPECTROMETRY.
PubMed: 19245862