WNK1_ARATH - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: WNK1_ARATH
• UniProt AC: Q9CAV6
• Protein Name: Serine/threonine-protein kinase WNK1
• Gene Name: WNK1
• Organism: Arabidopsis thaliana (Mouse-ear cress).
• Sequence Length: 700
• Protein Description: Regulates flowering time by modulating the photoperiod pathway. Phosphorylates APRR3..
• Protein Sequence: MNNLSYLEPDYSEFVEVDPTGRYGRYNEVLGKGASKTVYRAFDEYEGIEVAWNQVKLYDFLQSPEDLERLYCEIHLLKTLKHKNIMKFYTSWVDTANRNINFVTELFTSGTLRQYRLRHKRVNIRAMKHWCRQILRGLHYLHSHDPPVIHRDLKCDNIFVNGNQGEVKIGDLGLAAILRKSHAAHCVGTPEFMAPEVYEEAYNELVDIYSFGMCILEMVTFDYPYSECTHPAQIYKKVMSGKKPDALYKVKDPEVKCFIEKCLATVSLRVSARELLDDPFLRIDDGEFDLRSVDMEDSVGPLYRQPHHLPDYYNYPSNSSSLNRQYSNGNYPSNSSSLNRQYSNGYNSHHEYQNGWAYNPAETEETHGIELFESRNNDDQEEEKKSGNVDITIKGKRRDDGGLFLRLRIADKEGRVRNIYFPFDIETDTALSVATEMVAELDMDDHGVTKIANMIDGEISSLVPSWRPGPEFEECLAAAAAANAASICNNCVSNRTSMGSVMDFLRTNPGANVIQCCRNGCGETHGRFEEITIRETEVRLRELWKLQQQQESRELSSIDSGHNHSEEEEEEEVLYEDPENMFSCEAGNEINHISGSGSFSFMPSKYCDEPSEKTENQVQQELRWLKAKCQIELRDIQDEQLKTRWPESGEEVEISPKDGFLGSVSGLGREEDTVKEMFGERLVPKCLKRTTSLPVDAIDS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
292	Phosphorylation	DGEFDLRSVDMEDSV CCCCCEEECCCCCCC	29.75	23328941
326	Phosphorylation	SSSLNRQYSNGNYPS CHHHCCCCCCCCCCC	10.81	23776212
327	Phosphorylation	SSLNRQYSNGNYPSN HHHCCCCCCCCCCCC	29.89	23776212
331	Phosphorylation	RQYSNGNYPSNSSSL CCCCCCCCCCCCHHC	14.94	23776212
333	Phosphorylation	YSNGNYPSNSSSLNR CCCCCCCCCCHHCCC	38.70	23776212
335	Phosphorylation	NGNYPSNSSSLNRQY CCCCCCCCHHCCCCC	26.16	23776212
392	Phosphorylation	KSGNVDITIKGKRRD HHCCCEEEECCEECC	16.51	19880383
496	Phosphorylation	NNCVSNRTSMGSVMD CHHHCCCCCHHHHHH	27.58	23776212
497	Phosphorylation	NCVSNRTSMGSVMDF HHHCCCCCHHHHHHH	20.22	23776212
500	Phosphorylation	SNRTSMGSVMDFLRT CCCCCHHHHHHHHHH	12.96	23776212
552	Phosphorylation	KLQQQQESRELSSID HHHHHHHHHHHHCCC	27.07	29654922
655	Phosphorylation	SGEEVEISPKDGFLG CCCCEEECCCCCCCC	16.64	30291188
663	Phosphorylation	PKDGFLGSVSGLGRE CCCCCCCCCCCCCCC	18.43	25561503
665	Phosphorylation	DGFLGSVSGLGREED CCCCCCCCCCCCCHH	29.96	25561503
690	Phosphorylation	VPKCLKRTTSLPVDA HHHHHHHCCCCCCHH	21.10	23776212
691	Phosphorylation	PKCLKRTTSLPVDAI HHHHHHCCCCCCHHC	32.09	23776212
692	Phosphorylation	KCLKRTTSLPVDAID HHHHHCCCCCCHHCC	30.02	23776212
700	Phosphorylation	LPVDAIDS------- CCCHHCCC-------	35.69	23776212

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of WNK1_ARATH !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of WNK1_ARATH !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of WNK1_ARATH !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
APRR3_ARATH	PRR3	physical	12506983
APRR3_ARATH	PRR3	physical	12091722

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.