IAA8_ARATH - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: IAA8_ARATH
• UniProt AC: Q38826
• Protein Name: Auxin-responsive protein IAA8
• Gene Name: IAA8
• Organism: Arabidopsis thaliana (Mouse-ear cress).
• Sequence Length: 321
• Subcellular Localization: Nucleus.
• Protein Description: Aux/IAA proteins are short-lived transcriptional factors that function as repressors of early auxin response genes at low auxin concentrations. Repression is thought to result from the interaction with auxin response factors (ARFs), proteins that bind to the auxin-responsive promoter element (AuxRE). Formation of heterodimers with ARF proteins may alter their ability to modulate early auxin response genes expression..
• Protein Sequence: MSYRLLSVDKDELVTSPCLKERNYLGLSDCSSVDSSTIPNVVGKSNLNFKATELRLGLPESQSPERETDFGLLSPRTPDEKLLFPLLPSKDNGSATTGHKNVVSGNKRGFADTWDEFSGVKGSVRPGGGINMMLSPKVKDVSKSIQEERSHAKGGLNNAPAAKAQVVGWPPIRSYRKNTMASSTSKNTDEVDGKPGLGVLFVKVSMDGAPYLRKVDLRTYTSYQQLSSALEKMFSCFTLGQCGLHGAQGRERMSEIKLKDLLHGSEFVLTYEDKDGDWMLVGDVPWEIFTETCQKLKIMKGSDSIGLAPGAVEKSKNKERV

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
61	Phosphorylation	LRLGLPESQSPERET EECCCCCCCCCCCCC	33.74	30407730
63	Phosphorylation	LGLPESQSPERETDF CCCCCCCCCCCCCCC	37.70	30407730
68	Phosphorylation	SQSPERETDFGLLSP CCCCCCCCCCCCCCC	42.73	30407730
74	Phosphorylation	ETDFGLLSPRTPDEK CCCCCCCCCCCCCHH	19.85	30291188
77	Phosphorylation	FGLLSPRTPDEKLLF CCCCCCCCCCHHHEE	38.18	25561503
97	Phosphorylation	KDNGSATTGHKNVVS CCCCCCCCCCCCCCC	36.68	22074104

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of IAA8_ARATH !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of IAA8_ARATH !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of IAA8_ARATH !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
IAA11_ARATH	IAA11	physical	21798944
ARFE_ARATH	MP	physical	22912871
ARFG_ARATH	NPH4	physical	22912871
ARFS_ARATH	ARF19	physical	22912871
ARFD_ARATH	ARF4	physical	23483289
ARFE_ARATH	MP	physical	23483289
ARFF_ARATH	ARF6	physical	23483289
ARFG_ARATH	NPH4	physical	23483289
ARFH_ARATH	ARF8	physical	23483289
ARFN_ARATH	ARF14	physical	23483289
ARFO_ARATH	ARF15	physical	23483289
ARFS_ARATH	ARF19	physical	23483289
ARFT_ARATH	ARF20	physical	23483289
ARFV_ARATH	ARF22	physical	23483289
IAA18_ARATH	IAA18	physical	21734647
IAA17_ARATH	AXR3	physical	21734647
IAA8_ARATH	IAA8	physical	21734647
ARFI_ARATH	ARF9	physical	21734647
IAA12_ARATH	IAA12	physical	21734647
IAA5_ARATH	IAA5	physical	21734647
IAA9_ARATH	IAA9	physical	21734647
IAA34_ARATH	IAA34	physical	21734647
IAA28_ARATH	IAA28	physical	21734647
IAA19_ARATH	IAA19	physical	21734647
IAA15_ARATH	IAA15	physical	21734647
ARFG_ARATH	NPH4	physical	21734647
ARFS_ARATH	ARF19	physical	21734647

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.