WIP3_ARATH - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: WIP3_ARATH
• UniProt AC: Q94AV5
• Protein Name: WPP domain-interacting protein 3
• Gene Name: WIP3
• Organism: Arabidopsis thaliana (Mouse-ear cress).
• Sequence Length: 459
• Subcellular Localization: Nucleus envelope . Nucleus membrane ; Single-pass membrane protein ; Cytoplasmic side .
• Protein Description: Mediates and enhances the nuclear envelope docking of RANGAP proteins mediated by WIT1 and WIT2 in the undifferentiated cells of root tips. [PubMed: 17600715 As component of the SUN-WIP-WIT2-KAKU1 complex, mediates the transfer of cytoplasmic forces to the nuclear envelope (NE), leading to nuclear shape changes]
• Protein Sequence: MNESVPDSVEDNGNSVPANGLLVLPDNDHEEGGVGSPQRSNSVESPGGSVHSTRKGFGLKKWRRIKRDGPVRDEAAPVDDGSKLLKRGLAGLVNPPSKHVEFSSVEARQSSEGSVGSVNMVHHPGVANGFSPDIGCMFAVGQAFEKSEEHSGNTIGGKNVVGGKVVSGSQEKLWSDTIKRASEERGDIEKEKPCSSLDSDLRSSDFVFSTGSVSVGNHGEKDERLTMNYIGGFSNEGQVKEEVQTYSRSENGNKEDDGESKKNNNHWADKDALADSIRSFAVLQEVLWKEVQSFQELGKESVLLHSNTDELSSDQPSHQNCKEDNSTSSGSKALILKEKVKLLEHKLEEARAALEAKEARIQELENSKIESELECIFQRKIETEIEHLMLTRSLSSLQVLQETKKLHSLKEDPVSNRGNILGKTCKLGFYILTQLILLVSILRFLVLQFSPASRLVIPT

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
40	Phosphorylation	GVGSPQRSNSVESPG CCCCCCCCCCCCCCC	28.36	23111157
42	Phosphorylation	GSPQRSNSVESPGGS CCCCCCCCCCCCCCC	28.63	23111157
45	Phosphorylation	QRSNSVESPGGSVHS CCCCCCCCCCCCCCC	27.04	19376835
49	Phosphorylation	SVESPGGSVHSTRKG CCCCCCCCCCCCCCC	23.67	19376835
52	Phosphorylation	SPGGSVHSTRKGFGL CCCCCCCCCCCCCCC	27.96	19376835
53	Phosphorylation	PGGSVHSTRKGFGLK CCCCCCCCCCCCCCH	22.86	19376835
82	Phosphorylation	AAPVDDGSKLLKRGL CCCCCCHHHHHHHHH	27.42	19880383
169	Phosphorylation	GGKVVSGSQEKLWSD CCEEEECCHHHHHHH	27.88	25561503
182	Phosphorylation	SDTIKRASEERGDIE HHHHHHHHHHHCCCC	43.98	25561503
212	Phosphorylation	DFVFSTGSVSVGNHG CEEEECCCEEECCCC	16.00	28011693
214	Phosphorylation	VFSTGSVSVGNHGEK EEECCCEEECCCCCC	26.46	28011693
393	Phosphorylation	EHLMLTRSLSSLQVL HHHHHHHCHHHHHHH	27.63	19880383
395	Phosphorylation	LMLTRSLSSLQVLQE HHHHHCHHHHHHHHH	30.19	30291188
396	Phosphorylation	MLTRSLSSLQVLQET HHHHCHHHHHHHHHH	28.28	19880383

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of WIP3_ARATH !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of WIP3_ARATH !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of WIP3_ARATH !!

Protein-Protein Interaction

Oops, there are no PPI records of WIP3_ARATH !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.