| UniProt ID | BUB1B_MOUSE | |
|---|---|---|
| UniProt AC | Q9Z1S0 | |
| Protein Name | Mitotic checkpoint serine/threonine-protein kinase BUB1 beta | |
| Gene Name | Bub1b | |
| Organism | Mus musculus (Mouse). | |
| Sequence Length | 1052 | |
| Subcellular Localization | Cytoplasm. Nucleus. Chromosome, centromere, kinetochore . Cytoplasmic in interphase cells (By similarity). Associates with the kinetochores in early prophase. Kinetochore localization requires BUB1, PLK1 and KNL1 (By similarity).. | |
| Protein Description | Essential component of the mitotic checkpoint. Required for normal mitosis progression and tumor suppression. The mitotic checkpoint delays anaphase until all chromosomes are properly attached to the mitotic spindle. One of its checkpoint functions is to inhibit the activity of the anaphase-promoting complex/cyclosome (APC/C) by blocking the binding of CDC20 to APC/C, independently of its kinase activity. The other is to monitor kinetochore activities that depend on the kinetochore motor CENPE. Required for kinetochore localization of CENPE. Negatively regulates PLK1 activity in interphase cells and suppresses centrosome amplification. Also implicated in triggering apoptosis in polyploid cells that exit aberrantly from mitotic arrest. Essential for tumor suppression. May play a role in regulating aging and fertility (By similarity).. | |
| Protein Sequence | MAEASEAMCLEGAEWELSKENIQPLRHGRVMSTLQGALAKQESAGHTALQQQKRAFESEIRFYSGDDPLDVWDRYINWTEQNYPQGGKESNMSALVERAIEALQGETRYYNDPRFLSLWIKLGHLCNEPLDMYSYLQSQGIGVSLAQFYISWAEEYEARENFKKADIIFQEGIERKAEPLDRLQSQHRQFQSRVSRQAFLALGNEEEEALEPSEPQRSSLAELKSRGKKMARAPISRVGGALKAPGQSRGFLNAVPQPVHGNRRITVFDENADTASRTELSKPVAQPWMAPPVPRAKENELQPGPWSTDRPAGRRPHDNPASVTSIPSVLPSFTPYVEESAQQTVMTPCKIEPSINHVLSTRKPGREEGDPLQRVQSHQQGCEEKKEKMMYCKEKIYAGVGEFSFEEIRAEVFRKKLKERREAELLTSAKKREEMQKQIEEMERRLKAMQAVQQEGAGGQQEEKMPTEDPARLQIASGPQEMSGVPLSCSICPLSSNPREISPAENILQEQPDSKGSSMPFSIFDESLSDKKDKSPATGGPQVLNAQRRPLSVLKTTEVGTTNEDVSPDICDELTELEPLSEDAIITGFRNVTLCPNPEDTCDFARAARLASTPFHEILSSKGIAADPEGLLQEEDLDGKAAEAHHTVHHQALIIKKLSPIIEESREATHSSGFSRSSSSAPSTSSIKGFQLLEKLELTNDGAEDAIQSPWCSQYRLQLLKSLLELSAFAEFSVEDRPMPVLEIGKEIELGPEDYVIKQEHLTCDDYRLFWVAPRSSAELTMIKASSQPIPWDFYINLKLKERLNEDYDQLCSCCQYQDGHVVWYQYINCSTLQNLLQHSEFVTHEIIVLIIYNLLTIVEKLHRAEIVHGDLSPRSLILRNRIHDPYDYVNKDDHAVRIMDFSYSVDLRVQLDAFAYSGFRTAQILEGQKILANCSSPYHVDLLGIADLAHLLLFKEHLHVFWDGLLWKLSQSTSELKDSELWNKFFVRILNASDKSTVSVLGELAAEMGGAFDATFHSHLNRALWKLGKTISPEALLTQQDKQPGGSQSPA | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 5 | Phosphorylation | ---MAEASEAMCLEG ---CCCHHHHHHHCC | 19.86 | 22067460 | |
| 32 | Phosphorylation | LRHGRVMSTLQGALA CCCHHHHHHHHHHHH | 24.10 | 22067460 | |
| 33 | Phosphorylation | RHGRVMSTLQGALAK CCHHHHHHHHHHHHH | 12.66 | 22067460 | |
| 43 | Phosphorylation | GALAKQESAGHTALQ HHHHHHHHHCCHHHH | 36.74 | 27149854 | |
| 64 | Phosphorylation | ESEIRFYSGDDPLDV HHCCCCCCCCCCCHH | 32.79 | 22067460 | |
| 225 | Phosphorylation | SSLAELKSRGKKMAR HHHHHHHHHCHHHHC | 59.91 | 25266776 | |
| 243 | Acetylation | SRVGGALKAPGQSRG HHHCCCCCCCCCCCC | 52.59 | 15522271 | |
| 266 | Phosphorylation | VHGNRRITVFDENAD CCCCCEEEEECCCCC | 17.20 | 25266776 | |
| 307 | Phosphorylation | ELQPGPWSTDRPAGR CCCCCCCCCCCCCCC | 24.46 | 22067460 | |
| 347 | Phosphorylation | SAQQTVMTPCKIEPS HHHCCCCCCCCCCCC | 22.62 | 22067460 | |
| 360 | Phosphorylation | PSINHVLSTRKPGRE CCCCCCCCCCCCCCC | 25.69 | 22067460 | |
| 361 | Phosphorylation | SINHVLSTRKPGREE CCCCCCCCCCCCCCC | 38.25 | 22067460 | |
| 377 | Phosphorylation | DPLQRVQSHQQGCEE CHHHHHHHHHCCCHH | 22.02 | 25266776 | |
| 397 | Phosphorylation | MYCKEKIYAGVGEFS HHHHHHHCCCCCCCC | 14.36 | - | |
| 427 | Phosphorylation | RREAELLTSAKKREE HHHHHHHHHHHHHHH | 38.98 | 28066266 | |
| 428 | Phosphorylation | REAELLTSAKKREEM HHHHHHHHHHHHHHH | 37.75 | 28066266 | |
| 502 | Phosphorylation | SSNPREISPAENILQ CCCCCCCCHHHHHHH | 17.19 | 28066266 | |
| 514 | Phosphorylation | ILQEQPDSKGSSMPF HHHHCCCCCCCCCCC | 45.67 | 25338131 | |
| 517 | Phosphorylation | EQPDSKGSSMPFSIF HCCCCCCCCCCCHHC | 27.48 | - | |
| 527 | Phosphorylation | PFSIFDESLSDKKDK CCHHCCHHHCCCCCC | 34.71 | 22067460 | |
| 529 | Phosphorylation | SIFDESLSDKKDKSP HHCCHHHCCCCCCCC | 57.58 | 22067460 | |
| 535 | Phosphorylation | LSDKKDKSPATGGPQ HCCCCCCCCCCCCHH | 29.87 | 28418008 | |
| 538 | Phosphorylation | KKDKSPATGGPQVLN CCCCCCCCCCHHHHC | 46.16 | 26824392 | |
| 557 | Phosphorylation | PLSVLKTTEVGTTNE CCCEEEECCCCCCCC | 27.38 | 23649490 | |
| 562 | Phosphorylation | KTTEVGTTNEDVSPD EECCCCCCCCCCCHH | 30.59 | 23649490 | |
| 567 | Phosphorylation | GTTNEDVSPDICDEL CCCCCCCCHHHHHHH | 29.22 | 23649490 | |
| 575 | Phosphorylation | PDICDELTELEPLSE HHHHHHHHCCCCCCC | 36.15 | 23649490 | |
| 581 | Phosphorylation | LTELEPLSEDAIITG HHCCCCCCCCCEEEC | 44.11 | 26745281 | |
| 601 | Phosphorylation | LCPNPEDTCDFARAA ECCCHHHCCHHHHHH | 16.59 | 22067460 | |
| 613 | Phosphorylation | RAARLASTPFHEILS HHHHHHCCCHHHHHH | 25.11 | 22067460 | |
| 620 | Phosphorylation | TPFHEILSSKGIAAD CCHHHHHHCCCCCCC | 35.35 | 22067460 | |
| 621 | Phosphorylation | PFHEILSSKGIAADP CHHHHHHCCCCCCCC | 31.30 | 22067460 | |
| 659 | Phosphorylation | ALIIKKLSPIIEESR HHHHHHHHHHHHHHH | 23.96 | 26824392 | |
| 665 | Phosphorylation | LSPIIEESREATHSS HHHHHHHHHHHHHHC | 23.72 | - | |
| 669 | Phosphorylation | IEESREATHSSGFSR HHHHHHHHHHCCCCC | 19.96 | 17203969 | |
| 671 | Phosphorylation | ESREATHSSGFSRSS HHHHHHHHCCCCCCC | 28.00 | 17203969 | |
| 672 | Phosphorylation | SREATHSSGFSRSSS HHHHHHHCCCCCCCC | 35.93 | 17203969 | |
| 675 | Phosphorylation | ATHSSGFSRSSSSAP HHHHCCCCCCCCCCC | 34.48 | 17203969 | |
| 679 | Phosphorylation | SGFSRSSSSAPSTSS CCCCCCCCCCCCCCC | 31.59 | 25266776 | |
| 683 | Phosphorylation | RSSSSAPSTSSIKGF CCCCCCCCCCCCCHH | 40.41 | - | |
| 686 | Phosphorylation | SSAPSTSSIKGFQLL CCCCCCCCCCHHHHH | 28.54 | 22067460 | |
| 699 | Phosphorylation | LLEKLELTNDGAEDA HHHHEECCCCCHHHH | 23.14 | 22067460 | |
| 781 | Phosphorylation | PRSSAELTMIKASSQ CCCCCEEEEEEECCC | 14.35 | - | |
| 873 | Phosphorylation | EIVHGDLSPRSLILR CCCCCCCCHHHHHHH | 24.02 | 22067460 | |
| 998 | Phosphorylation | LNASDKSTVSVLGEL HCCCCCCHHHHHHHH | 23.65 | - | |
| 1031 | Phosphorylation | ALWKLGKTISPEALL HHHHHCCCCCHHHHH | 25.53 | 25619855 | |
| 1033 | Phosphorylation | WKLGKTISPEALLTQ HHHCCCCCHHHHHCC | 23.17 | 25619855 | |
| 1039 | Phosphorylation | ISPEALLTQQDKQPG CCHHHHHCCCCCCCC | 25.65 | 25619855 | |
| 1048 | Phosphorylation | QDKQPGGSQSPA--- CCCCCCCCCCCC--- | 33.14 | 25619855 | |
| 1050 | Phosphorylation | KQPGGSQSPA----- CCCCCCCCCC----- | 25.21 | 22942356 |
| Modified Location | Modified Residue | Modification | Function | Reference |
|---|---|---|---|---|
| 243 | K | Acetylation |
| - |
| 659 | S | Phosphorylation |
| - |
| 1033 | S | Phosphorylation |
| - |
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of BUB1B_MOUSE !! | ||||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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