ANF_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ANF_HUMAN
• UniProt AC: P01160
• Protein Name: Natriuretic peptides A
• Gene Name: NPPA
• Organism: Homo sapiens (Human).
• Sequence Length: 153
• Subcellular Localization: Secreted.
• Protein Description: Hormone playing a key role in cardiovascular homeostasis through regulation of natriuresis, diuresis, and vasodilation. Also plays a role in female pregnancy by promoting trophoblast invasion and spiral artery remodeling in uterus. Specifically binds and stimulates the cGMP production of the NPR1 receptor. Binds the clearance receptor NPR3..
• Protein Sequence: MSSFSTTTVSFLLLLAFQLLGQTRANPMYNAVSNADLMDFKNLLDHLEEKMPLEDEVVPPQVLSEPNEEAGAALSPLPEVPPWTGEVSPAQRDGGALGRGPWDSSDRSALLKSKLRALLTAPRSLRRSSCFGGRMDRIGAQSGLGCNSFRYRR

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Phosphorylation	------MSSFSTTTV ------CCCCCHHHH	39.84	24043423
3	Phosphorylation	-----MSSFSTTTVS -----CCCCCHHHHH	23.17	24043423
5	Phosphorylation	---MSSFSTTTVSFL ---CCCCCHHHHHHH	27.13	24043423
6	Phosphorylation	--MSSFSTTTVSFLL --CCCCCHHHHHHHH	25.19	24043423
7	Phosphorylation	-MSSFSTTTVSFLLL -CCCCCHHHHHHHHH	24.81	24043423
8	Phosphorylation	MSSFSTTTVSFLLLL CCCCCHHHHHHHHHH	17.78	24043423
10	Phosphorylation	SFSTTTVSFLLLLAF CCCHHHHHHHHHHHH	14.21	24043423
23	Phosphorylation	AFQLLGQTRANPMYN HHHHHCCCCCCCCHH	29.92	24043423
41	Acetylation	NADLMDFKNLLDHLE CHHHCCHHHHHHHHH	42.28	30590889
75	O-linked_Glycosylation	EEAGAALSPLPEVPP CCCCCCCCCCCCCCC	21.47	OGP
120	Phosphorylation	SKLRALLTAPRSLRR HHHHHHHHCCHHHHC	35.15	26670566
128	Phosphorylation	APRSLRRSSCFGGRM CCHHHHCCCCCCCCH	25.65	22210691
129	Phosphorylation	PRSLRRSSCFGGRMD CHHHHCCCCCCCCHH	16.20	22210691
151	Phosphorylation	LGCNSFRYRR----- CCCCCCCCCC-----	14.55	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of ANF_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
129	S	Phosphorylation	[Urodilatin]: Phosphorylation on Ser-129 decreases vasorelaxant activity.	2528951

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ANF_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
41_HUMAN	EPB41	physical	12542678
ANPRC_HUMAN	NPR3	physical	16870210
UBQL1_HUMAN	UBQLN1	physical	25416956
P20D1_HUMAN	PM20D1	physical	28514442
NUDT8_HUMAN	NUDT8	physical	28514442
NGAL_HUMAN	LCN2	physical	28514442
OBSCN_HUMAN	OBSCN	physical	28514442
GDPD3_HUMAN	GDPD3	physical	28514442
SMYD2_HUMAN	SMYD2	physical	28514442
NDUF7_HUMAN	NDUFAF7	physical	28514442
DR9C7_HUMAN	SDR9C7	physical	28514442
NDUF5_HUMAN	NDUFAF5	physical	28514442
LX15B_HUMAN	ALOX15B	physical	28514442
MPPA_HUMAN	PMPCA	physical	28514442
MAP11_HUMAN	METAP1	physical	28514442
ECM1_HUMAN	ECM1	physical	28514442
IMPA2_HUMAN	IMPA2	physical	28514442
MPPB_HUMAN	PMPCB	physical	28514442
TGM1_HUMAN	TGM1	physical	28514442
INVO_HUMAN	IVL	physical	28514442
LX12B_HUMAN	ALOX12B	physical	28514442
PLAK_HUMAN	JUP	physical	28514442
PPAP_HUMAN	ACPP	physical	28514442
MAOX_HUMAN	ME1	physical	28514442
SPB3_HUMAN	SERPINB3	physical	28514442
ACADV_HUMAN	ACADVL	physical	28514442
CBPA4_HUMAN	CPA4	physical	28514442
CATL2_HUMAN	CTSV	physical	28514442
SPB4_HUMAN	SERPINB4	physical	28514442
CPNS2_HUMAN	CAPNS2	physical	28514442
DEFM_HUMAN	PDF	physical	28514442
S10A9_HUMAN	S100A9	physical	28514442
CYTM_HUMAN	CST6	physical	28514442
ARGI1_HUMAN	ARG1	physical	28514442
PMVK_HUMAN	PMVK	physical	28514442
POF1B_HUMAN	POF1B	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• 615745: Atrial standstill 2 (ATRST2)
• 612201: Atrial fibrillation, familial, 6 (ATFB6)
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.