dbPTM

ATLAS_DROME - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	ATLAS_DROME
UniProt AC	Q9VC57
Protein Name	Atlastin
Gene Name	atl
Organism	Drosophila melanogaster (Fruit fly).
Sequence Length	541
Subcellular Localization	Endoplasmic reticulum membrane Multi-pass membrane protein . Golgi apparatus membrane Multi-pass membrane protein . Colocalizes with microtubules (PubMed:19341724).
Protein Description	GTPase tethering membranes through formation of trans-homooligomers and mediating homotypic fusion of endoplasmic reticulum membranes. Functions in endoplasmic reticulum tubular network biogenesis. May also regulate microtubule polymerization and Golgi biogenesis. Required for dopaminergic neurons survival and the growth of muscles and synapses at neuromuscular junctions..
Protein Sequence	MGGSAVQVINASEEHTFVLNEDALSEVLMRDEVKDRFVCVVSVAGAFRKGKSFLLDFFLRYMYSKYVHHDATDWLGGESDPLEGFSWRGGSERDTTGILMWSDIFLHDYPNGDKIAIILLDTQGAFDSQSTVRDCATVFALSTMLSSVQIYNLSQNIQEDDLQHLQLFTEYGRLALADTGKKPFQRLQFLVRDWSFPYEAEYGALGGDKILKRRLEVSDKQHPELQSLRRHISSCFTEVACFLMPHPGLNVATNPKFDGRLQDITPEFKSSLRSLVPMLLAPDNLVYKEISGQRVRARDLIQYFQSYMNIYKGNELPEPKSMLVATAEANHLTAVAAAKELYGQLMEEVCGGTRPYLSTAHLQTEHLRVKDKALFQFAAKRKMGGEEFTEKFRKQLEDDLEEVFTNYQAHNESKNIFKAARTPAVYFACAVIMYILSGIFGLVGLYTFANFCNLVMGVALLTLALWAYIRYSGELSDFGGKLDDFATLLWEKFMRPIYHGCMEKGIHHVATHATEMAVGGGAASYRSQTSVNASNGKVKRS

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
514	Phosphorylation	HHVATHATEMAVGGG HHHHCHHHHCCCCCC	20.77	17030474
527	Phosphorylation	GGAASYRSQTSVNAS CCHHHHCCCCEECCC	29.58	27626673
530	Phosphorylation	ASYRSQTSVNASNGK HHHCCCCEECCCCCC	13.02	19429919

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of ATLAS_DROME !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of ATLAS_DROME !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of ATLAS_DROME !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
TERA_DROME	TER94	physical	23790629
HSP7C_DROME	Hsc70-3	physical	23790629
HSP7D_DROME	Hsc70-4	physical	23790629
ATLAS_DROME	atl	physical	23790629
HSP7A_DROME	Hsc70-1	physical	23790629
HSP75_DROME	Hsp70Bb	physical	23790629
HSP73_DROME	Hsp70Bb	physical	23790629
HSP72_DROME	Hsp70Ba	physical	23790629
HSP68_DROME	Hsp68	physical	23790629
HSP7B_DROME	Hsc70-2	physical	23790629
RAB26_DROME	Rab26	physical	23790629
RAB6_DROME	Rab6	physical	23790629
RAB3_DROME	Rab3	physical	23790629
PSMD3_DROME	Rpn3	physical	23790629
PRS8_DROME	Rpt6	physical	23790629
DHE3_DROME	Gdh	physical	23790629
ENO_DROME	Eno	physical	23790629
SDHA_DROME	SdhA	physical	23790629
PGM_DROME	Pgm	physical	23790629
IDH3A_DROME	l(1)G0156	physical	23790629
PUR6_DROME	ade5	physical	23790629
MAL1_DROME	Mal-A1	physical	23790629
GYS_DROME	GlyS	physical	23790629
GSTS1_DROME	GstS1	physical	23790629
DHB4_DROME	Mfe2	physical	23790629
FAS1_DROME	Fas1	physical	23790629
PPN_DROME	Ppn	physical	23790629
PABP_DROME	pAbp	physical	23790629
SQD_DROME	sqd	physical	23790629
CAZ_DROME	caz	physical	23790629
NHP2_DROME	NHP2	physical	23790629
DRI_DROME	retn	physical	23790629
KPYK_DROME	PyK	physical	23790629
GBLP_DROME	Rack1	physical	23790629
GCH1_DROME	Pu	physical	23790629
SCA_DROME	sca	physical	23790629
VATD1_DROME	Vha36-1	physical	23790629
NDUS1_DROME	ND75	physical	23790629
LAM0_DROME	Lam	physical	23790629
SPAST_DROME	spas	genetic	19341724
ATLAS_DROME	atl	physical	21368113
ATLAS_DROME	atl	physical	25407413
ATLAS_DROME	atl	physical	21690399
ATLAS_DROME	atl	physical	25825753

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of ATLAS_DROME

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Phosphoproteome analysis of Drosophila melanogaster embryos."; Zhai B., Villen J., Beausoleil S.A., Mintseris J., Gygi S.P.; J. Proteome Res. 7:1675-1682(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-514, AND MASSSPECTROMETRY.	18327897 [Abstract]