SPAST_DROME - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: SPAST_DROME
• UniProt AC: Q8I0P1
• Protein Name: Spastin {ECO:0000255|HAMAP-Rule:MF_03021}
• Gene Name: spas {ECO:0000255|HAMAP-Rule:MF_03021}
• Organism: Drosophila melanogaster (Fruit fly).
• Sequence Length: 758
• Subcellular Localization: Membrane ; Peripheral membrane protein . Cytoplasm, cytoskeleton, microtubule organizing center, centrosome . Cytoplasm, cytoskeleton . Chromosome . Lipid droplet . Forms a intramembrane hairpin-like structure in the membrane (By similarity). Colocal
• Protein Description: ATP-dependent microtubule severing protein. Stimulates microtubule minus-end depolymerization and poleward microtubule flux in the mitotic spindle. [PubMed: 15242610]
• Protein Sequence: MVRTKNQSSSSSASSSSTKSPIKSSSGAGSSGGGLGGRQSTHRSSSASNVAAVVAGGSSAAGGGSSSNRRSPGSSPDGDDDTTTTDDLTPTTCSPRSGHHHSYGGYSSSVHKQNLYVVSFPIIFLFNVLRSLIYQLFCIFRYLYGASTKVIYRPHRRDCNIEIVVQNSSKEQQQSLNHPSELNREGDGQEQQLSNQPQRFRPIQPLEMAANRPGGGYSPGPGDPLLAKQKHHHRRAFEYISKALKIDEENEGHKELAIELYRKGIKELEDGIAVDCWSGRGDVWDRAQRLHDKMQTNLSMARDRLHFLALREQDLQMQRLSLKEKQKEEAQSKPQKTREPMLAGMTNEPMKLRVRSSGYGPKATTSAQPTASGRKLTIGSKRPVNLAVANKSQTLPRNLGSKTSVGAVQRQPAKTAATPPAVRRQFSSGRNTPPQRSRTPINNNGPSGSGASTPVVSVKGVEQKLVQLILDEIVEGGAKVEWTDIAGQDVAKQALQEMVILPSVRPELFTGLRAPAKGLLLFGPPGNGKTLLARAVATECSATFLNISAASLTSKYVGDGEKLVRALFAVARHMQPSIIFIDEVDSLLSERSSSEHEASRRLKTEFLVEFDGLPGNPDGDRIVVLAATNRPQELDEAALRRFTKRVYVSLPDEQTRELLLNRLLQKQGSPLDTEALRRLAKITDGYSGSDLTALAKDAALEPIRELNVEQVKCLDISAMRAITEQDFHSSLKRIRRSVAPQSLNSYEKWSQDYGDITI

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
20	Phosphorylation	ASSSSTKSPIKSSSG CCCCCCCCCCCCCCC	31.76	27794539
415	Phosphorylation	VQRQPAKTAATPPAV ECCCCCCCCCCCHHH	24.51	27626673
418	Phosphorylation	QPAKTAATPPAVRRQ CCCCCCCCCHHHHHH	27.60	22668510
437	Phosphorylation	RNTPPQRSRTPINNN CCCCCCCCCCCCCCC	34.95	21082442
439	Phosphorylation	TPPQRSRTPINNNGP CCCCCCCCCCCCCCC	29.75	18202664

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of SPAST_DROME !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of SPAST_DROME !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of SPAST_DROME !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
ATLAS_DROME	atl	physical	19341724

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.