dbPTM

PUR6_DROME - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	PUR6_DROME
UniProt AC	Q9I7S8
Protein Name	Multifunctional protein ADE2
Gene Name	ade5 {ECO:0000312\|EMBL:AAG22346.2, ECO:0000312\|FlyBase:FBgn0020513}
Organism	Drosophila melanogaster (Fruit fly).
Sequence Length	429
Subcellular Localization
Protein Description
Protein Sequence	MSTTTTASIEGYKLGKVIIEGKTKQVYDLPEQPGLCLLLSKDRITAGDGVKAHDLAGKAEISNTTNGQVFRLLNEAGIRTAYVKQCGAKAFIARKCQMIPIEWVTRRLATGSFLKRNVGVPEGYRFSPPKQETFFKDDANHDPQWSEEQIVSAKFELNGLVIGQDEVDIMRRTTLLVFEILERAWQTKNCALIDMKVEFGICDDGNIVLADIIDSDSWRLWPAGDKRLMVDKQVYRNLASVTASDLDTVKRNFIWVAEQLADIVPKKDHLVVILMGSASDISHSEKIATSCRSLGLNVELRVSSAHKGPEETLRIVREYESVMSNLIFVAVAGRSNGLGPVVSGSTNYPVINCPPVKSDNMQVDVWSSLNLPSGLGCATVLYPEAAALHAATILGLGNFMVWSKLRVKALNNFITLKKADKELRGVRNA

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
3	Phosphorylation	-----MSTTTTASIE -----CCCEEECEEC	27.19	27794539
8	Phosphorylation	MSTTTTASIEGYKLG CCCEEECEECCEEEE	21.05	27794539
58	Acetylation	KAHDLAGKAEISNTT CHHHHCCCCEEEECC	36.92	21791702
84	Acetylation	GIRTAYVKQCGAKAF CCCEEEHHHHCCHHH	27.48	21791702
110	Phosphorylation	WVTRRLATGSFLKRN HHHHHHHCCCHHHCC	37.64	23607784
112	Phosphorylation	TRRLATGSFLKRNVG HHHHHCCCHHHCCCC	24.05	19429919
115	Acetylation	LATGSFLKRNVGVPE HHCCCHHHCCCCCCC	39.66	21791702
240	Phosphorylation	QVYRNLASVTASDLD HHHHHHHCCCHHHHH	24.14	21082442

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of PUR6_DROME !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of PUR6_DROME !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of PUR6_DROME !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
PUR6_DROME	ade5	physical	14605208
TFP8L_DROME	CG4091	physical	22036573

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of PUR6_DROME

Related Literatures of Post-Translational Modification