| UniProt ID | SHOC2_MOUSE | |
|---|---|---|
| UniProt AC | O88520 | |
| Protein Name | Leucine-rich repeat protein SHOC-2 | |
| Gene Name | Shoc2 | |
| Organism | Mus musculus (Mouse). | |
| Sequence Length | 582 | |
| Subcellular Localization | Cytoplasm. Nucleus. Translocates from cytoplasm to nucleus upon growth factor stimulation.. | |
| Protein Description | Regulatory subunit of protein phosphatase 1 (PP1c) that acts as a M-Ras/MRAS effector and participates in MAPK pathway activation. Upon M-Ras/MRAS activation, targets PP1c to specifically dephosphorylate the 'Ser-259' inhibitory site of RAF1 kinase and stimulate RAF1 activity at specialized signaling complexes (By similarity).. | |
| Protein Sequence | MSSSLGKEKDSKEKDPKVPSAKEREKESKASGGFGKESKEKEPKAKGKDAKDGKKESSAAQPGVAFSVDNTIKRPNPAPGTRKKSSNAEVIKELNKCREENSMRLDLSKRSIHILPPSVKELTQLTELYLYSNKLQSLPAEVGCLVNLMTLALSENSLTSLPDSLDNLKKLRMLDLRHNKLREIPSVVYRLDSLTTLYLRFNRITTVEKDIKNLPKLSMLSIRENKIKQLPAEIGELCNLITLDVAHNQLEHLPKEIGNCTQITNLDLQHNDLLDLPDTIGNLSSLNRLGLRYNRLSAIPRSLAKCSALEELNLENNNISTLPESLLSSLVKLNSLTLARNCFQLYPVGGPSQFSTIYSLNMEHNRINKIPFGIFSRAKVLSKLNMKDNQLTSLPLDFGTWTSMVELNLATNQLTKIPEDVSGLVSLEVLILSNNLLKKLPHGLGNLRKLRELDLEENKLESLPNEIAYLKDLQKLVLTNNQLSTLPRGIGHLTNLTHLGLGENLLTHLPEEIGTLENLEELYLNDNPNLHSLPFELALCSKLSIMSIENCPLSHLPPQIVAGGPSFIIQFLKMQGPYRAMV | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 20 | Phosphorylation | EKDPKVPSAKEREKE CCCCCCCCHHHHHHH | 55.76 | 25338131 | |
| 28 | Phosphorylation | AKEREKESKASGGFG HHHHHHHHHHCCCCC | 44.59 | 20495213 | |
| 41 | Acetylation | FGKESKEKEPKAKGK CCHHHHCCCCHHCCC | 80.97 | 19849151 | |
| 67 | Phosphorylation | AQPGVAFSVDNTIKR CCCCEEEEECCCCCC | 20.87 | 22871156 | |
| 71 | Phosphorylation | VAFSVDNTIKRPNPA EEEEECCCCCCCCCC | 24.34 | 29899451 | |
| 85 | Phosphorylation | APGTRKKSSNAEVIK CCCCCCCCCCHHHHH | 31.68 | 27841257 | |
| 102 | Phosphorylation | NKCREENSMRLDLSK HHHHHHHCCCCCCHH | 14.46 | 24719451 | |
| 111 | Phosphorylation | RLDLSKRSIHILPPS CCCCHHCCEECCCCC | 23.43 | - | |
| 118 | Phosphorylation | SIHILPPSVKELTQL CEECCCCCHHHHHHH | 43.83 | - | |
| 131 | Phosphorylation | QLTELYLYSNKLQSL HHHHHHHHCCCCCCC | 9.17 | 28576409 | |
| 205 | Phosphorylation | YLRFNRITTVEKDIK HHHHHCCCCHHHHHH | 22.88 | 20139300 | |
| 261 | Phosphorylation | PKEIGNCTQITNLDL CHHHCCCEECCCCCC | 27.31 | 25367039 | |
| 264 | Phosphorylation | IGNCTQITNLDLQHN HCCCEECCCCCCCCC | 21.66 | 25367039 | |
| 279 | Phosphorylation | DLLDLPDTIGNLSSL CHHCCCCCCCCHHHH | 28.92 | 25367039 | |
| 284 | Phosphorylation | PDTIGNLSSLNRLGL CCCCCCHHHHHHHCC | 36.46 | 25367039 | |
| 285 | Phosphorylation | DTIGNLSSLNRLGLR CCCCCHHHHHHHCCC | 32.60 | 25367039 | |
| 297 | Phosphorylation | GLRYNRLSAIPRSLA CCCHHHHCCCCHHHH | 22.40 | 22942356 | |
| 369 | Ubiquitination | MEHNRINKIPFGIFS CCCCCCCCCCCCHHH | 49.76 | 22790023 | |
| 383 | Ubiquitination | SRAKVLSKLNMKDNQ HHHHHHHHCCCCCCC | 39.45 | 27667366 | |
| 485 | Phosphorylation | LTNNQLSTLPRGIGH HCCCCCCCCCCCCHH | 49.74 | 22067460 | |
| 578 | Phosphorylation | FLKMQGPYRAMV--- HHHHCCCCCCCC--- | 20.16 | 29514104 |
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of SHOC2_MOUSE !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of SHOC2_MOUSE !! | ||||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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