LITAF_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: LITAF_HUMAN
• UniProt AC: Q99732
• Protein Name: Lipopolysaccharide-induced tumor necrosis factor-alpha factor {ECO:0000303|PubMed:10200294}
• Gene Name: LITAF
• Organism: Homo sapiens (Human).
• Sequence Length: 161
• Subcellular Localization: Cytoplasm . Nucleus . Lysosome membrane ; Peripheral membrane protein ; Cytoplasmic side . Early endosome membrane . Late endosome membrane . Endosome membrane ; Peripheral membrane protein ; Cytoplasmic side . Cell membrane ; Peripheral membrane protein
• Protein Description: Plays a role in endosomal protein trafficking and in targeting proteins for lysosomal degradation. [PubMed: 23166352 Plays a role in targeting endocytosed EGFR and ERGG3 for lysosomal degradation, and thereby helps downregulate downstream signaling cascades]
• Protein Sequence: MSVPGPYQAATGPSSAPSAPPSYEETVAVNSYYPTPPAPMPGPTTGLVTGPDGKGMNPPSYYTQPAPIPNNNPITVQTVYVQHPITFLDRPIQMCCPSCNKMIVSQLSYNAGALTWLSCGSLCLLGCIAGCCFIPFCVDALQDVDHYCPNCRALLGTYKRL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Phosphorylation	------MSVPGPYQA ------CCCCCCCCC	36.70	28348404
14	Phosphorylation	YQAATGPSSAPSAPP CCCCCCCCCCCCCCC	40.24	28348404
15	Phosphorylation	QAATGPSSAPSAPPS CCCCCCCCCCCCCCC	47.54	28348404
18	Phosphorylation	TGPSSAPSAPPSYEE CCCCCCCCCCCCCCC	53.80	28348404
23	Phosphorylation	APSAPPSYEETVAVN CCCCCCCCCCCEEEE	24.45	-
31	Phosphorylation	EETVAVNSYYPTPPA CCCEEEEEEECCCCC	21.31	25884760
32	Phosphorylation	ETVAVNSYYPTPPAP CCEEEEEEECCCCCC	14.30	28348404
33	Phosphorylation	TVAVNSYYPTPPAPM CEEEEEEECCCCCCC	10.64	28348404
54	Sumoylation	LVTGPDGKGMNPPSY CEECCCCCCCCCCCC	63.47	-
60	Phosphorylation	GKGMNPPSYYTQPAP CCCCCCCCCCCCCCC	31.84	25884760
60 (in isoform 2)	Phosphorylation	-	31.84	27642862
61	Phosphorylation	KGMNPPSYYTQPAPI CCCCCCCCCCCCCCC	19.12	-
62	Phosphorylation	GMNPPSYYTQPAPIP CCCCCCCCCCCCCCC	11.84	-
62 (in isoform 2)	Phosphorylation	-	11.84	27642862
63	Phosphorylation	MNPPSYYTQPAPIPN CCCCCCCCCCCCCCC	21.61	-
63 (in isoform 2)	Phosphorylation	-	21.61	27642862
80 (in isoform 2)	Phosphorylation	-	9.59	27642862
105	Phosphorylation	SCNKMIVSQLSYNAG CCCHHHHHHHHCCCC	17.93	20058876
137	S-palmitoylation	GCCFIPFCVDALQDV HHHHHHHHHHHHHCC	1.96	29575903
138 (in isoform 3)	Phosphorylation	-	5.02	-
144 (in isoform 3)	Phosphorylation	-	2.93	-
159	Ubiquitination	RALLGTYKRL----- HHHHHHHCCC-----	47.24	33845483
159	2-Hydroxyisobutyrylation	RALLGTYKRL----- HHHHHHHCCC-----	47.24	-
159	Acetylation	RALLGTYKRL----- HHHHHHHCCC-----	47.24	27452117
159 (in isoform 1)	Ubiquitination	-	47.24	21890473
189	Ubiquitination	----------------------------------- -----------------------------------		21890473

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of LITAF_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of LITAF_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of LITAF_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
NEDD4_HUMAN	NEDD4	physical	16118794
TS101_HUMAN	TSG101	physical	16118794
STAT6_HUMAN	STAT6	physical	15793005
BAG3_HUMAN	BAG3	physical	25416956
CACO2_HUMAN	CALCOCO2	physical	25416956
STAM2_HUMAN	STAM2	physical	25416956
UBQL1_HUMAN	UBQLN1	physical	25416956
REEP6_HUMAN	REEP6	physical	25416956
TS101_HUMAN	TSG101	physical	25963657
NEDD4_HUMAN	NEDD4	physical	25963657
NED4L_HUMAN	NEDD4L	physical	25963657
ITCH_HUMAN	ITCH	physical	25963657
WWP1_HUMAN	WWP1	physical	25963657
WWP2_HUMAN	WWP2	physical	25963657
TOM1_HUMAN	TOM1	physical	25963657
TAB2_HUMAN	TAB2	physical	25963657
R3HD1_HUMAN	R3HDM1	physical	28514442
HPCL4_HUMAN	HPCAL4	physical	28514442
CYHR1_HUMAN	CYHR1	physical	28514442
BCS1_HUMAN	BCS1L	physical	28514442
UBB_HUMAN	UBB	physical	28514442
PUM2_HUMAN	PUM2	physical	28514442
FGFR2_HUMAN	FGFR2	physical	28514442
PTPRD_HUMAN	PTPRD	physical	28514442
LRP10_HUMAN	LRP10	physical	28514442
APOB_HUMAN	APOB	physical	28514442
REEP5_HUMAN	REEP5	physical	28514442
RASF3_HUMAN	RASSF3	physical	28514442
FGFR1_HUMAN	FGFR1	physical	28514442
HECW2_HUMAN	HECW2	physical	28514442
CD320_HUMAN	CD320	physical	28514442
NED4L_HUMAN	NEDD4L	physical	28514442
PUM1_HUMAN	PUM1	physical	28514442
BMR1A_HUMAN	BMPR1A	physical	28514442
SYCC_HUMAN	CARS	physical	28514442
RN149_HUMAN	RNF149	physical	28514442
TTC33_HUMAN	TTC33	physical	28514442
NEDD4_HUMAN	NEDD4	physical	28514442
ARL8A_HUMAN	ARL8A	physical	28514442
ACOX1_HUMAN	ACOX1	physical	28514442
SDCB1_HUMAN	SDCBP	physical	28514442

Drug and Disease Associations

• Kegg Disease
• H00264: Charcot-Marie-Tooth disease (CMT); Hereditary motor and sensory neuropathy; Peroneal muscular atroph
• OMIM Disease
• 601098: Charcot-Marie-Tooth disease 1C (CMT1C)
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.