CAH14_HUMAN - dbPTM
CAH14_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID CAH14_HUMAN
UniProt AC Q9ULX7
Protein Name Carbonic anhydrase 14
Gene Name CA14
Organism Homo sapiens (Human).
Sequence Length 337
Subcellular Localization Membrane
Single-pass type I membrane protein .
Protein Description Reversible hydration of carbon dioxide..
Protein Sequence MLFSALLLEVIWILAADGGQHWTYEGPHGQDHWPASYPECGNNAQSPIDIQTDSVTFDPDLPALQPHGYDQPGTEPLDLHNNGHTVQLSLPSTLYLGGLPRKYVAAQLHLHWGQKGSPGGSEHQINSEATFAELHIVHYDSDSYDSLSEAAERPQGLAVLGILIEVGETKNIAYEHILSHLHEVRHKDQKTSVPPFNLRELLPKQLGQYFRYNGSLTTPPCYQSVLWTVFYRRSQISMEQLEKLQGTLFSTEEEPSKLLVQNYRALQPLNQRMVFASFIQAGSSYTTGEMLSLGVGILVGCLCLLLAVYFIARKIRKKRLENRKSVVFTSAQATTEA
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
174PhosphorylationGETKNIAYEHILSHL
CCCCCHHHHHHHHHH		12.30-
179PhosphorylationIAYEHILSHLHEVRH
HHHHHHHHHHHHHCC		24.33-
213N-linked_GlycosylationLGQYFRYNGSLTTPP
HCCCCCCCCCCCCCC		29.3524374484
234PhosphorylationWTVFYRRSQISMEQL
HHHHHHHHCCCHHHH		23.91-
237PhosphorylationFYRRSQISMEQLEKL
HHHHHCCCHHHHHHH		14.5025907765
286PhosphorylationIQAGSSYTTGEMLSL
HHCCCCCCHHCHHHH		30.21-
325PhosphorylationKRLENRKSVVFTSAQ
HHHCCCCCEEEEECC		21.9225072903
329PhosphorylationNRKSVVFTSAQATTE
CCCCEEEEECCCCCC		16.1425072903
330PhosphorylationRKSVVFTSAQATTEA
CCCEEEEECCCCCCC		13.6125072903
334PhosphorylationVFTSAQATTEA----
EEEECCCCCCC----		17.0621406692
335PhosphorylationFTSAQATTEA-----
EEECCCCCCC-----		32.6921406692
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of CAH14_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of CAH14_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of CAH14_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
ZN273_HUMANZNF273physical
21988832
EI2BE_HUMANEIF2B5physical
26186194
THADA_HUMANTHADAphysical
26186194
EI2BD_HUMANEIF2B4physical
26186194
NF1_HUMANNF1physical
26186194
ATR_HUMANATRphysical
26186194
NU160_HUMANNUP160physical
26186194
TNPO2_HUMANTNPO2physical
26186194
S22AI_HUMANSLC22A18physical
26186194
FACD2_HUMANFANCD2physical
26186194
RNBP6_HUMANRANBP6physical
26186194
PEX19_HUMANPEX19physical
26186194
SAAL1_HUMANSAAL1physical
26186194
CIP2A_HUMANKIAA1524physical
26186194
HEAT1_HUMANHEATR1physical
26186194
COG2_HUMANCOG2physical
26186194
EXOC1_HUMANEXOC1physical
26186194
IQCB1_HUMANIQCB1physical
26186194
EI2BA_HUMANEIF2B1physical
26186194
XPO4_HUMANXPO4physical
26186194
MON2_HUMANMON2physical
26186194
COG4_HUMANCOG4physical
26186194
EXOC7_HUMANEXOC7physical
26186194
LTN1_HUMANLTN1physical
26186194
PLAP_HUMANPLAAphysical
26186194
AP1M1_HUMANAP1M1physical
26186194
EXOC5_HUMANEXOC5physical
26186194
NUP85_HUMANNUP85physical
26186194
KIF14_HUMANKIF14physical
26186194
MTOR_HUMANMTORphysical
26186194
EI2BB_HUMANEIF2B2physical
26186194
CNDH2_HUMANNCAPH2physical
26186194
EI2BG_HUMANEIF2B3physical
26186194
COG7_HUMANCOG7physical
26186194
KNTC1_HUMANKNTC1physical
26186194
EXC6B_HUMANEXOC6Bphysical
26186194
EXOC6_HUMANEXOC6physical
26186194
EXOC8_HUMANEXOC8physical
26186194
RRP1_HUMANRRP1physical
26186194
XPO6_HUMANXPO6physical
26186194
ERMP1_HUMANERMP1physical
26186194
COG8_HUMANCOG8physical
26186194
CIP2A_HUMANKIAA1524physical
28514442
S38A7_HUMANSLC38A7physical
28514442
ATR_HUMANATRphysical
28514442
NF1_HUMANNF1physical
28514442
DNM1L_HUMANDNM1Lphysical
28514442
PEX19_HUMANPEX19physical
28514442
EI2BD_HUMANEIF2B4physical
28514442
EI2BE_HUMANEIF2B5physical
28514442
XPO6_HUMANXPO6physical
28514442
EI2BG_HUMANEIF2B3physical
28514442
EXOC5_HUMANEXOC5physical
28514442
THADA_HUMANTHADAphysical
28514442
S22AI_HUMANSLC22A18physical
28514442
IQCB1_HUMANIQCB1physical
28514442
EXC6B_HUMANEXOC6Bphysical
28514442
TNPO2_HUMANTNPO2physical
28514442
EVA1B_HUMANEVA1Bphysical
28514442
EI2BB_HUMANEIF2B2physical
28514442
COG2_HUMANCOG2physical
28514442
RNBP6_HUMANRANBP6physical
28514442
XPO4_HUMANXPO4physical
28514442
EXOC7_HUMANEXOC7physical
28514442
EI2BA_HUMANEIF2B1physical
28514442
LTN1_HUMANLTN1physical
28514442
MTOR_HUMANMTORphysical
28514442
SAAL1_HUMANSAAL1physical
28514442
COG7_HUMANCOG7physical
28514442
CNDH2_HUMANNCAPH2physical
28514442
COG4_HUMANCOG4physical
28514442
KIF14_HUMANKIF14physical
28514442
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
D00218 Acetazolamide (JP16/USP/INN); Diamox (TN)
D00219 Acetohexamide (JP16/USP/INN); Dymelor (TN)
D00518 Diclofenamide (JP16/INN); Dichlorphenamide (USP); Daranide (TN)
D00652 Brinzolamide (JAN/USP/INN); Azopt (TN)
D00653 Dorzolamide hydrochloride (JP16/USP); Trusopt (TN)
D00655 Methazolamide (JAN/USP/INN); Neptazane (TN)
D01196 Acetazolamide sodium (JAN); Diamox (TN)
D01822 Clofenamide (JAN/INN)
D02441 Ethoxzolamide; Cardrase (TN)
D03845 Sezolamide hydrochloride (USAN)
D07871 Dorzolamide (INN); Trusopt (TN)
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of CAH14_HUMAN

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Related Literatures of Post-Translational Modification

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