ABCG1_HUMAN - dbPTM
ABCG1_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID ABCG1_HUMAN
UniProt AC P45844
Protein Name ATP-binding cassette sub-family G member 1
Gene Name ABCG1
Organism Homo sapiens (Human).
Sequence Length 678
Subcellular Localization Endoplasmic reticulum membrane
Multi-pass membrane protein . Golgi apparatus membrane
Multi-pass membrane protein . Predominantly localized in the intracellular compartments mainly associated with the endoplasmic reticulum (ER) and Golgi membrane
Protein Description Transporter involved in macrophage lipid homeostasis. Is an active component of the macrophage lipid export complex. Could also be involved in intracellular lipid transport processes. The role in cellular lipid homeostasis may not be limited to macrophages..
Protein Sequence MACLMAAFSVGTAMNASSYSAEMTEPKSVCVSVDEVVSSNMEATETDLLNGHLKKVDNNLTEAQRFSSLPRRAAVNIEFRDLSYSVPEGPWWRKKGYKTLLKGISGKFNSGELVAIMGPSGAGKSTLMNILAGYRETGMKGAVLINGLPRDLRCFRKVSCYIMQDDMLLPHLTVQEAMMVSAHLKLQEKDEGRREMVKEILTALGLLSCANTRTGSLSGGQRKRLAIALELVNNPPVMFFDEPTSGLDSASCFQVVSLMKGLAQGGRSIICTIHQPSAKLFELFDQLYVLSQGQCVYRGKVCNLVPYLRDLGLNCPTYHNPADFVMEVASGEYGDQNSRLVRAVREGMCDSDHKRDLGGDAEVNPFLWHRPSEEVKQTKRLKGLRKDSSSMEGCHSFSASCLTQFCILFKRTFLSIMRDSVLTHLRITSHIGIGLLIGLLYLGIGNEAKKVLSNSGFLFFSMLFLMFAALMPTVLTFPLEMGVFLREHLNYWYSLKAYYLAKTMADVPFQIMFPVAYCSIVYWMTSQPSDAVRFVLFAALGTMTSLVAQSLGLLIGAASTSLQVATFVGPVTAIPVLLFSGFFVSFDTIPTYLQWMSYISYVRYGFEGVILSIYGLDREDLHCDIDETCHFQKSEAILRELDVENAKLYLDFIVLGIFFISLRLIAYFVLRYKIRAER
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
19 (in isoform 3)Phosphorylation-14.9229083192
20 (in isoform 3)Phosphorylation-21.5029083192
21 (in isoform 3)Phosphorylation-11.4429083192
22 (in isoform 3)Phosphorylation-40.4729083192
23 (in isoform 2)Phosphorylation-5.27-
25 (in isoform 2)Phosphorylation-49.79-
26 (in isoform 3)Phosphorylation-25.6729083192
30S-palmitoylationMTEPKSVCVSVDEVV
CCCCCEEEEEHHHHH		2.1423388354
32PhosphorylationEPKSVCVSVDEVVSS
CCCEEEEEHHHHHHC		20.8029759185
32UbiquitinationEPKSVCVSVDEVVSS
CCCEEEEEHHHHHHC		20.8029967540
51UbiquitinationTETDLLNGHLKKVDN
CCHHHHHHHHHHHCC		27.7229967540
54UbiquitinationDLLNGHLKKVDNNLT
HHHHHHHHHHCCCCC		45.1129967540
55UbiquitinationLLNGHLKKVDNNLTE
HHHHHHHHHCCCCCH		62.27-
56UbiquitinationLNGHLKKVDNNLTEA
HHHHHHHHCCCCCHH		10.2129967540
65UbiquitinationNNLTEAQRFSSLPRR
CCCCHHHHHHCCCCC		40.2329967540
67PhosphorylationLTEAQRFSSLPRRAA
CCHHHHHHCCCCCEE		32.9029262532
68PhosphorylationTEAQRFSSLPRRAAV
CHHHHHHCCCCCEEE		39.4124719451
76UbiquitinationLPRRAAVNIEFRDLS
CCCCEEEEEEEECCC		24.2829967540
80UbiquitinationAAVNIEFRDLSYSVP
EEEEEEEECCCCCCC		31.0429967540
83PhosphorylationNIEFRDLSYSVPEGP
EEEEECCCCCCCCCC		21.4628796482
84PhosphorylationIEFRDLSYSVPEGPW
EEEECCCCCCCCCCH		22.4528796482
84 (in isoform 8)Phosphorylation-22.45-
85PhosphorylationEFRDLSYSVPEGPWW
EEECCCCCCCCCCHH		28.0228796482
85UbiquitinationEFRDLSYSVPEGPWW
EEECCCCCCCCCCHH		28.0229967540
95UbiquitinationEGPWWRKKGYKTLLK
CCCHHHHHCHHHHHH		59.9229967540
98UbiquitinationWWRKKGYKTLLKGIS
HHHHHCHHHHHHHHC		41.1729967540
99UbiquitinationWRKKGYKTLLKGISG
HHHHCHHHHHHHHCC		28.9229967540
99PhosphorylationWRKKGYKTLLKGISG
HHHHCHHHHHHHHCC		28.9246156955
100UbiquitinationRKKGYKTLLKGISGK
HHHCHHHHHHHHCCC		3.9929967540
102UbiquitinationKGYKTLLKGISGKFN
HCHHHHHHHHCCCCC		58.2629967540
104UbiquitinationYKTLLKGISGKFNSG
HHHHHHHHCCCCCCC		4.7329967540
105PhosphorylationKTLLKGISGKFNSGE
HHHHHHHCCCCCCCC		44.6023286773
107UbiquitinationLLKGISGKFNSGELV
HHHHHCCCCCCCCEE		34.2829967540
109UbiquitinationKGISGKFNSGELVAI
HHHCCCCCCCCEEEE		53.2229967540
110PhosphorylationGISGKFNSGELVAIM
HHCCCCCCCCEEEEE		36.4625072903
113UbiquitinationGKFNSGELVAIMGPS
CCCCCCCEEEEECCC		3.4429967540
118UbiquitinationGELVAIMGPSGAGKS
CCEEEEECCCCCCHH		13.7029967540
120PhosphorylationLVAIMGPSGAGKSTL
EEEEECCCCCCHHHH		35.2325072903
125PhosphorylationGPSGAGKSTLMNILA
CCCCCCHHHHHHHHH		26.3430576142
137PhosphorylationILAGYRETGMKGAVL
HHHCCHHHCCCCEEE		33.3130576142
140 (in isoform 8)Phosphorylation-45.0922210691
140UbiquitinationGYRETGMKGAVLING
CCHHHCCCCEEEECC		45.09-
141 (in isoform 8)Phosphorylation-16.4222210691
148 (in isoform 8)Phosphorylation-2.4522210691
154S-palmitoylationGLPRDLRCFRKVSCY
CCCCCHHHHHEEEEE		5.1423388354
167UbiquitinationCYIMQDDMLLPHLTV
EEEECCCCCCCCCCH		5.8022505724
186UbiquitinationMVSAHLKLQEKDEGR
HHHHHHHHHHCCHHH		11.3522505724
189UbiquitinationAHLKLQEKDEGRREM
HHHHHHHCCHHHHHH		48.3922505724
191UbiquitinationLKLQEKDEGRREMVK
HHHHHCCHHHHHHHH		66.7122505724
200UbiquitinationRREMVKEILTALGLL
HHHHHHHHHHHHHHH		3.2522505724
296 (in isoform 8)Ubiquitination-2.54-
300UbiquitinationGQCVYRGKVCNLVPY
CCEEECCCCHHCHHH		34.32-
315S-palmitoylationLRDLGLNCPTYHNPA
HHHCCCCCCCCCCHH		2.9923388354
332UbiquitinationVMEVASGEYGDQNSR
HHHHHCCCCCCHHHH		43.7929967540
351UbiquitinationVREGMCDSDHKRDLG
HHHCCCCCCCCCCCC		36.3729967540
354UbiquitinationGMCDSDHKRDLGGDA
CCCCCCCCCCCCCCC		53.2329967540
356UbiquitinationCDSDHKRDLGGDAEV
CCCCCCCCCCCCCCC		55.2429967540
365UbiquitinationGGDAEVNPFLWHRPS
CCCCCCCCCCCCCCC		30.7729967540
376UbiquitinationHRPSEEVKQTKRLKG
CCCCHHHHHHHHCCC		56.3729967540
379UbiquitinationSEEVKQTKRLKGLRK
CHHHHHHHHCCCCCC		53.92-
394S-palmitoylationDSSSMEGCHSFSASC
CCCCCCCCHHHCHHH		1.2223388354
406S-palmitoylationASCLTQFCILFKRTF
HHHHHHHHHHHHHHH		1.5823388354
412PhosphorylationFCILFKRTFLSIMRD
HHHHHHHHHHHHHCH		29.5324719451
420PhosphorylationFLSIMRDSVLTHLRI
HHHHHCHHHHHHHHH		14.5224719451
494PhosphorylationEHLNYWYSLKAYYLA
HHHHHHHHHHHHHHH		14.8424719451
667PhosphorylationISLRLIAYFVLRYKI
HHHHHHHHHHHHHHH		6.2928674151
672PhosphorylationIAYFVLRYKIRAER-
HHHHHHHHHHHHCC-		13.4528674151
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of ABCG1_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference
315CPalmitoylation

23388354
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of ABCG1_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
KIF2C_CRIGRKif2cphysical
26296893
ACACA_MOUSEAcacaphysical
26296893
KS6A3_MOUSERps6ka3physical
26296893
SYTC_MOUSETarsphysical
26296893
CLIC1_MOUSEClic1physical
26296893
AP1G1_MOUSEAp1g1physical
26296893
CAZA2_MOUSECapza2physical
26296893
CDK1_MOUSECdk1physical
26296893
DDX3X_MOUSEDdx3xphysical
26296893
ERF3A_MOUSEGspt1physical
26296893
GYS1_MOUSEGys1physical
26296893
PLAK_MOUSEJupphysical
26296893
PKP1_MOUSEPkp1physical
26296893
RIR1_MOUSERrm1physical
26296893
STAT3_MOUSEStat3physical
26296893
PSMD2_MOUSEPsmd2physical
26296893
PCBP1_MOUSEPcbp1physical
26296893
COPG2_MOUSECopg2physical
26296893
SPAT5_MOUSESpata5physical
26296893
HUWE1_MOUSEHuwe1physical
26296893
GHC1_MOUSESlc25a22physical
26296893
COPB_MOUSECopb1physical
26296893
VPS11_MOUSEVps11physical
26296893
NUP93_MOUSENup93physical
26296893
GCP2_MOUSETubgcp2physical
26296893
WRIP1_MOUSEWrnip1physical
26296893
NAT10_MOUSENat10physical
26296893
EXOS2_MOUSEExosc2physical
26296893
DDX27_MOUSEDdx27physical
26296893
TNPO1_MOUSETnpo1physical
26296893
ACLY_RATAclyphysical
26296893
AT1A1_RATAtp1a1physical
26296893
DYN2_RATDnm2physical
26296893
DCTN1_RATDctn1physical
26296893
NCKP1_RATNckap1physical
26296893
TBA1A_RATTuba1aphysical
26296893
ACON_RATAco2physical
26296893
NEDD4_HUMANNEDD4physical
26296893
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of ABCG1_HUMAN

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Related Literatures of Post-Translational Modification

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