GYS1_MOUSE - dbPTM
GYS1_MOUSE - PTM Information in dbPTM
Basic Information of Protein
UniProt ID GYS1_MOUSE
UniProt AC Q9Z1E4
Protein Name Glycogen [starch] synthase, muscle
Gene Name Gys1
Organism Mus musculus (Mouse).
Sequence Length 738
Subcellular Localization
Protein Description Transfers the glycosyl residue from UDP-Glc to the non-reducing end of alpha-1,4-glucan..
Protein Sequence MPLSRSLSVSSLPGLEDWEDEFDPENAVLFEVAWEVANKVGGIYTVLQTKAKVTGDEWGDNYYLVGPYTEQGVRTQVELLEPPTPELKRTLDSMNSKGCKVYFGRWLIEGGPLVVLLDVGASAWALERWKGELWDTCNIGVPWYDREANDAVLFGFLTTWFLGEFLAQNEEKPYVVAHFHEWLAGVGLCLCRARRLPVATIFTTHATLLGRYLCAGAVDFYNNLENFNVDKEAGERQIYHRYCMERAAAHCAHVFTTVSQITAIEAQHLLKRKPDIVTPNGLNVKKFSAMHEFQNLHAQSKARIQEFVRGHFYGHLDFNLDKTLYFFIAGRYEFSNKGADVFLEALARLNYLLRVNGSEQTVVAFFIMPARTNNFNVETLKGQAVRKQLWDTANTVKEKFGRKLYESLLVGSLPDMNKMLDKEDFTMMKRAIFATQRQSFPPVCTHNMLDDSSDPILTTIRRIGLFNSSADRVKVIFHPEFLSSTSPLLPVDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSISTNLSGFGCFMEEHIADPSAYGIYILDRRFRSLDDSCSQLTSFLYSFCQQSRRQRIIQRNRTERLSDLLDWKYLGRYYMSARHMALAKAFPDHFTYEPHEVDATQGYRYPRPASVPPSPSLSRHSSPHQSEDEEEPRDGPLGEDSERYDEEEEAAKDRRNIRAPEWPRRASCSSSTGGSKRSNSVDTGPSSSLSTPTEPLSPTSSLGEERN
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
6Phosphorylation--MPLSRSLSVSSLP
--CCCCCCCCCCCCC		22.9426745281
8PhosphorylationMPLSRSLSVSSLPGL
CCCCCCCCCCCCCCC		22.6215561936
10PhosphorylationLSRSLSVSSLPGLED
CCCCCCCCCCCCCCC		23.8426745281
11PhosphorylationSRSLSVSSLPGLEDW
CCCCCCCCCCCCCCC		36.1117257813
44PhosphorylationANKVGGIYTVLQTKA
HHHHCCEEEEEEEEE		8.2828542873
45PhosphorylationNKVGGIYTVLQTKAK
HHHCCEEEEEEEEEE		16.9022210690
90PhosphorylationPTPELKRTLDSMNSK
CCHHHHHHHHHCCCC		33.0721183079
96PhosphorylationRTLDSMNSKGCKVYF
HHHHHCCCCCCEEEE		23.0628464351
381AcetylationNFNVETLKGQAVRKQ
CCCHHHHCHHHHHHH		57.2942497131
381UbiquitinationNFNVETLKGQAVRKQ
CCCHHHHCHHHHHHH		57.2927667366
405PhosphorylationEKFGRKLYESLLVGS
HHHHHHHHHHHHHCC		13.4025367039
407PhosphorylationFGRKLYESLLVGSLP
HHHHHHHHHHHCCCC		17.2826643407
412PhosphorylationYESLLVGSLPDMNKM
HHHHHHCCCCHHHHH		29.2926824392
439PhosphorylationIFATQRQSFPPVCTH
HHHHCCCCCCCCCCC		41.7422817900
452PhosphorylationTHNMLDDSSDPILTT
CCCCCCCCCCCHHHH		35.9928464351
468PhosphorylationRRIGLFNSSADRVKV
HHHCCCCCCCCCEEE		21.4028542873
469PhosphorylationRIGLFNSSADRVKVI
HHCCCCCCCCCEEEE		34.9828464351
599UbiquitinationLSDLLDWKYLGRYYM
HHHHHCHHHHHHHHH		30.2022790023
631PhosphorylationEPHEVDATQGYRYPR
CCCCCCCCCCCCCCC		20.3329514104
634PhosphorylationEVDATQGYRYPRPAS
CCCCCCCCCCCCCCC		9.3529899451
636PhosphorylationDATQGYRYPRPASVP
CCCCCCCCCCCCCCC		8.6327742792
640PhosphorylationGYRYPRPASVPPSPS
CCCCCCCCCCCCCCC		25.1717242355
641PhosphorylationYRYPRPASVPPSPSL
CCCCCCCCCCCCCCC		37.5325521595
645PhosphorylationRPASVPPSPSLSRHS
CCCCCCCCCCCCCCC		22.5025521595
647PhosphorylationASVPPSPSLSRHSSP
CCCCCCCCCCCCCCC		43.2325521595
649PhosphorylationVPPSPSLSRHSSPHQ
CCCCCCCCCCCCCCC		32.0816803855
652PhosphorylationSPSLSRHSSPHQSED
CCCCCCCCCCCCCCC		44.4425521595
653PhosphorylationPSLSRHSSPHQSEDE
CCCCCCCCCCCCCCC		21.9225521595
657PhosphorylationRHSSPHQSEDEEEPR
CCCCCCCCCCCCCCC		43.9425521595
672PhosphorylationDGPLGEDSERYDEEE
CCCCCCCCHHHCHHH		21.4827742792
675PhosphorylationLGEDSERYDEEEEAA
CCCCCHHHCHHHHHH		24.5325619855
683UbiquitinationDEEEEAAKDRRNIRA
CHHHHHHHHHHCCCC		59.8322790023
698PhosphorylationPEWPRRASCSSSTGG
CCCCCCCCCCCCCCC		16.8425266776
700PhosphorylationWPRRASCSSSTGGSK
CCCCCCCCCCCCCCC		25.4829514104
701PhosphorylationPRRASCSSSTGGSKR
CCCCCCCCCCCCCCC		35.9327681418
702PhosphorylationRRASCSSSTGGSKRS
CCCCCCCCCCCCCCC		18.1227681418
703PhosphorylationRASCSSSTGGSKRSN
CCCCCCCCCCCCCCC		47.7327681418
709PhosphorylationSTGGSKRSNSVDTGP
CCCCCCCCCCCCCCC		36.8727742792
711PhosphorylationGGSKRSNSVDTGPSS
CCCCCCCCCCCCCCC		23.7125521595
714PhosphorylationKRSNSVDTGPSSSLS
CCCCCCCCCCCCCCC		49.1627742792
717PhosphorylationNSVDTGPSSSLSTPT
CCCCCCCCCCCCCCC		33.6325619855
718PhosphorylationSVDTGPSSSLSTPTE
CCCCCCCCCCCCCCC		38.1325619855
719PhosphorylationVDTGPSSSLSTPTEP
CCCCCCCCCCCCCCC		30.5826239621
721PhosphorylationTGPSSSLSTPTEPLS
CCCCCCCCCCCCCCC		34.0027742792
722PhosphorylationGPSSSLSTPTEPLSP
CCCCCCCCCCCCCCC		39.2525521595
724PhosphorylationSSSLSTPTEPLSPTS
CCCCCCCCCCCCCCC		50.7727742792
728PhosphorylationSTPTEPLSPTSSLGE
CCCCCCCCCCCCCCC		36.5325521595
730PhosphorylationPTEPLSPTSSLGEER
CCCCCCCCCCCCCCC		27.8021082442
731PhosphorylationTEPLSPTSSLGEERN
CCCCCCCCCCCCCCC		27.2723737553
732PhosphorylationEPLSPTSSLGEERN-
CCCCCCCCCCCCCC-		42.7625521595
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources
8SPhosphorylationKinaseAMPK-FAMILY-GPS
8SPhosphorylationKinasePKA-FAMILY-GPS
8SPhosphorylationKinasePKA-Uniprot
8SPhosphorylationKinaseAMPK-Uniprot
641SPhosphorylationKinaseDYRK2Q5U4C9
Uniprot
641SPhosphorylationKinaseGSK3-ALPHAQ2NL51
Uniprot
641SPhosphorylationKinaseGSK3-BETAQ9WV60
Uniprot
641SPhosphorylationKinasePASKQ8CEE6
Uniprot
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference
8SPhosphorylation

15561936
641SPhosphorylation

15561936
641SPhosphorylation

15561936
641SPhosphorylation

15561936
641SPhosphorylation

15561936
645SPhosphorylation

21183079
645SPhosphorylation

21183079
649SPhosphorylation

21183079
653SPhosphorylation

21183079
657SPhosphorylation

21183079
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of GYS1_MOUSE !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions

Oops, there are no PPI records of GYS1_MOUSE !!
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of GYS1_MOUSE

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"The alpha2-5'AMP-activated protein kinase is a site 2 glycogensynthase kinase in skeletal muscle and is responsive to glucoseloading.";
Jorgensen S.B., Nielsen J.N., Birk J.B., Olsen G.S., Viollet B.,Andreelli F., Schjerling P., Vaulont S., Hardie D.G., Hansen B.F.,Richter E.A., Wojtaszewski J.F.;
Diabetes 53:3074-3081(2004).
Cited for: PHOSPHORYLATION AT SER-8.

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