KIF2C_CRIGR - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: KIF2C_CRIGR
• UniProt AC: P70096
• Protein Name: Kinesin-like protein KIF2C
• Gene Name: KIF2C
• Organism: Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus).
• Sequence Length: 718
• Subcellular Localization: Cytoplasm, cytoskeleton . Nucleus . Chromosome, centromere . Chromosome, centromere, kinetochore . Associates with the microtubule network at the growing distal tip (the plus-end) of microtubules, through interaction with MTUS2/TIP150 and MAPRE1 (Pub
• Protein Description: In complex with KIF18B, constitutes the major microtubule plus-end depolymerizing activity in mitotic cells (By similarity). Regulates the turnover of microtubules at the kinetochore and functions in chromosome segregation during mitosis. [PubMed: 14960279 Plays a role in chromosome congression and is required for the lateral to end-on conversion of the chromosome-microtubule attachment (By similarity]
• Protein Sequence: MESLPARLFPGLSIKIQRSNGLIHSANISTVNVEKSCVSVEWIEGGNTKGKEIDFDDVAAINPELLQLLPLHPKDNLPLQENVTVPKQKRRSVNSKIPAPKEGLRSRSTRMSTVPEVRIATQENEMEVELPVATNSRKQFSVATGLPRPSCPAMTELPLSMVSEEAEEQVHPTRSTSSANPARRKSCIVKEMEKMKNKREEKRAQNSEIRIKRAQEYDSSFPNWEFARMIKEFRVTIECHPLTLTDPTEEHRICVCVRKRPLNKQELAKKEIDVISVPSKCLLFVHEPKLKVDLTKYLENQAFCFDFAFDETASNEVVYRFTARPLVQTIFEGGKATCFAYGQTGSGKTHTMGGDLSGKSQNTSKGIYAMASRDVFLLKSQPRYRNLNLEVYVTFFEIYNGKVFDLLNKKAKLRVLEDSKQQVQVVGLQEYLVNCADDVIKMLNMGSACRTSGQTFANSNSSRSHACFQILLRAKGRLHGKFSLVDLAGNERGADTSSADRQTRMEGAEINKSLLALKECIRALGQNKAHTPFRESKLTQVLRDSFIGENSRTCMIAMISPGISSCEYTLNTLRYADRVKELSPHSGLSGEQPIQMETEEMEASSNGTSLAVNFKEEEELSSQMSSFNEAMSQIRELEERAMEELREIIQQGPGWLELSEMTDQPDYDLETFVNKAESALTQQTKHFSALREVIKALRVAMQLEEQASKQMNSKKRHQ

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
3	Phosphorylation	-----MESLPARLFP -----CCCCCCHHCC	38.05	-
19	Phosphorylation	LSIKIQRSNGLIHSA CEEEEEECCCCEEEE	20.90	-
92	Phosphorylation	VPKQKRRSVNSKIPA CCCHHCCCCCCCCCC	29.68	14960279
106	Phosphorylation	APKEGLRSRSTRMST CCHHHHCCCCCCCCC	35.31	14960279
108	Phosphorylation	KEGLRSRSTRMSTVP HHHHCCCCCCCCCCC	22.93	14960279
112	Phosphorylation	RSRSTRMSTVPEVRI CCCCCCCCCCCCEEE	23.98	14960279
163	Phosphorylation	ELPLSMVSEEAEEQV CCCHHHCCHHHHHHC	22.52	-
186	Phosphorylation	ANPARRKSCIVKEME CCHHHHHHHHHHHHH	13.78	14960279
513	Phosphorylation	EGAEINKSLLALKEC CHHHHHHHHHHHHHH	24.91	-
626	Phosphorylation	ELSSQMSSFNEAMSQ HHHHHHHHHHHHHHH	27.09	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
92	S	Phosphorylation	Kinase	AURKB	-	PhosphoELM

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of KIF2C_CRIGR !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of KIF2C_CRIGR !!

Protein-Protein Interaction

Oops, there are no PPI records of KIF2C_CRIGR !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Aurora B regulates MCAK at the mitotic centromere.";
Andrews P.D., Ovechkina Y., Morrice N., Wagenbach M., Duncan K.,Wordeman L., Swedlow J.R.;
Dev. Cell 6:253-268(2004).
Cited for: FUNCTION, SUBCELLULAR LOCATION, PHOSPHORYLATION AT SER-92; SER-106;SER-108; SER-112 AND SER-186, AND MUTAGENESIS OF SER-92; SER-106;SER-108; SER-112 AND SER-186.
PubMed: 14960279