S22AG_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: S22AG_HUMAN
• UniProt AC: Q86VW1
• Protein Name: Solute carrier family 22 member 16
• Gene Name: SLC22A16
• Organism: Homo sapiens (Human).
• Sequence Length: 577
• Subcellular Localization: Membrane ; Multi-pass membrane protein . Cell membrane . Detected in the plasma membrane of Sertoli cells and in the luminal membrane of epithelial cells in the epididymis.
• Protein Description: High affinity carnitine transporter; the uptake is partially sodium-ion dependent. Thought to mediate the L-carnitine secretion mechanism from testis epididymal epithelium into the lumen which is involved in the maturation of spermatozoa. Also transports organic cations such as tetraethylammonium (TEA) and doxorubicin. The uptake of TEA is inhibited by various organic cations. The uptake of doxorubicin is sodium-independent..
• Protein Sequence: MGSRHFEGIYDHVGHFGRFQRVLYFICAFQNISCGIHYLASVFMGVTPHHVCRPPGNVSQVVFHNHSNWSLEDTGALLSSGQKDYVTVQLQNGEIWELSRCSRNKRENTSSLGYEYTGSKKEFPCVDGYIYDQNTWKSTAVTQWNLVCDRKWLAMLIQPLFMFGVLLGSVTFGYFSDRLGRRVVLWATSSSMFLFGIAAAFAVDYYTFMAARFFLAMVASGYLVVGFVYVMEFIGMKSRTWASVHLHSFFAVGTLLVALTGYLVRTWWLYQMILSTVTVPFILCCWVLPETPFWLLSEGRYEEAQKIVDIMAKWNRASSCKLSELLSLDLQGPVSNSPTEVQKHNLSYLFYNWSITKRTLTVWLIWFTGSLGFYSFSLNSVNLGGNEYLNLFLLGVVEIPAYTFVCIAMDKVGRRTVLAYSLFCSALACGVVMVIPQKHYILGVVTAMVGKFAIGAAFGLIYLYTAELYPTIVRSLAVGSGSMVCRLASILAPFSVDLSSIWIFIPQLFVGTMALLSGVLTLKLPETLGKRLATTWEEAAKLESENESKSSKLLLTTNNSGLEKTEAITPRDSGLGE

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
57	N-linked_Glycosylation	HVCRPPGNVSQVVFH CCCCCCCCEEEEEEE	35.72	UniProtKB CARBOHYD
65	N-linked_Glycosylation	VSQVVFHNHSNWSLE EEEEEEECCCCCCHH	28.90	UniProtKB CARBOHYD
68	N-linked_Glycosylation	VVFHNHSNWSLEDTG EEEECCCCCCHHHHC	25.46	UniProtKB CARBOHYD
108	N-linked_Glycosylation	CSRNKRENTSSLGYE ECCCCCCCCCCCCCE	49.66	UniProtKB CARBOHYD
238	Phosphorylation	MEFIGMKSRTWASVH HHHHCCCCCCEEEHH	26.50	24719451
345	N-linked_Glycosylation	PTEVQKHNLSYLFYN CHHHHHHCEEEEEEC	37.40	UniProtKB CARBOHYD
352	N-linked_Glycosylation	NLSYLFYNWSITKRT CEEEEEECCCCCCCC	20.77	UniProtKB CARBOHYD
475	Phosphorylation	LYPTIVRSLAVGSGS HHHHHHHHHCCCCCC	15.13	-
535	Phosphorylation	LGKRLATTWEEAAKL HHHHHHHCHHHHHHH	25.85	-
546	N-linked_Glycosylation	AAKLESENESKSSKL HHHHHCCCCCCCCCE	69.03	UniProtKB CARBOHYD
556	Phosphorylation	KSSKLLLTTNNSGLE CCCCEEEEECCCCCC	27.70	-
558	N-linked_Glycosylation	SKLLLTTNNSGLEKT CCEEEEECCCCCCEE	35.12	UniProtKB CARBOHYD
560	Phosphorylation	LLLTTNNSGLEKTEA EEEEECCCCCCEEEC	46.99	-
569	Phosphorylation	LEKTEAITPRDSGLG CCEEECCCCCCCCCC	21.22	24719451

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of S22AG_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of S22AG_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of S22AG_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
GBP5_HUMAN	GBP5	physical	28514442
ACSM1_HUMAN	ACSM1	physical	28514442
TM104_HUMAN	TMEM104	physical	28514442
APBA3_HUMAN	APBA3	physical	28514442
RAB21_HUMAN	RAB21	physical	28514442
S2546_HUMAN	SLC25A46	physical	28514442
CXG1_HUMAN	GJC1	physical	28514442
MBOA5_HUMAN	LPCAT3	physical	28514442
PXMP2_HUMAN	PXMP2	physical	28514442
MTX3_HUMAN	MTX3	physical	28514442
AT2B2_HUMAN	ATP2B2	physical	28514442
TMM56_HUMAN	TMEM56	physical	28514442
S29A1_HUMAN	SLC29A1	physical	28514442
ATLA3_HUMAN	ATL3	physical	28514442
S26A2_HUMAN	SLC26A2	physical	28514442
MFSD8_HUMAN	MFSD8	physical	28514442
SPPL3_HUMAN	SPPL3	physical	28514442
SERC1_HUMAN	SERINC1	physical	28514442
TM164_HUMAN	TMEM164	physical	28514442
SNG2_HUMAN	SYNGR2	physical	28514442
KMCP1_HUMAN	SLC25A30	physical	28514442
FND3A_HUMAN	FNDC3A	physical	28514442
FLVC1_HUMAN	FLVCR1	physical	28514442
TSN15_HUMAN	TSPAN15	physical	28514442
PAQR1_HUMAN	ADIPOR1	physical	28514442
MIC25_HUMAN	CHCHD6	physical	28514442
NOCT_HUMAN	CCRN4L	physical	28514442
PLCB_HUMAN	AGPAT2	physical	28514442

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.