ACSM1_HUMAN - dbPTM
ACSM1_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID ACSM1_HUMAN
UniProt AC Q08AH1
Protein Name Acyl-coenzyme A synthetase ACSM1, mitochondrial
Gene Name ACSM1
Organism Homo sapiens (Human).
Sequence Length 577
Subcellular Localization Mitochondrion matrix.
Protein Description Has medium-chain fatty acid:CoA ligase activity with broad substrate specificity (in vitro). Acts on acids from C(4) to C(11) and on the corresponding 3-hydroxy- and 2,3- or 3,4-unsaturated acids (in vitro). Functions as GTP-dependent lipoate-activating enzyme that generates the substrate for lipoyltransferase (By similarity)..
Protein Sequence MQWLMRFRTLWGIHKSFHNIHPAPSQLRCRSLSEFGAPRWNDYEVPEEFNFASYVLDYWAQKEKEGKRGPNPAFWWVNGQGDEVKWSFREMGDLTRRVANVFTQTCGLQQGDHLALMLPRVPEWWLVAVGCMRTGIIFIPATILLKAKDILYRLQLSKAKGIVTIDALASEVDSIASQCPSLKTKLLVSDHSREGWLDFRSLVKSASPEHTCVKSKTLDPMVIFFTSGTTGFPKMAKHSHGLALQPSFPGSRKLRSLKTSDVSWCLSDSGWIVATIWTLVEPWTAGCTVFIHHLPQFDTKVIIQTLLKYPINHFWGVSSIYRMILQQDFTSIRFPALEHCYTGGEVVLPKDQEEWKRRTGLLLYENYGQSETGLICATYWGMKIKPGFMGKATPPYDVQVIDDKGSILPPNTEGNIGIRIKPVRPVSLFMCYEGDPEKTAKVECGDFYNTGDRGKMDEEGYICFLGRSDDIINASGYRIGPAEVESALVEHPAVAESAVVGSPDPIRGEVVKAFIVLTPQFLSHDKDQLTKELQQHVKSVTAPYKYPRKVEFVSELPKTITGKIERKELRKKETGQM
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
33PhosphorylationQLRCRSLSEFGAPRW
HHHCCCHHHHCCCCC		31.9328348404
85SuccinylationNGQGDEVKWSFREMG
CCCCCEEEEEHHHHH		34.76-
85SuccinylationNGQGDEVKWSFREMG
CCCCCEEEEEHHHHH		34.76-
95PhosphorylationFREMGDLTRRVANVF
HHHHHHHHHHHHHHH		22.5946158143
146AcetylationIPATILLKAKDILYR
EEHHHHHHHHHHHHH		50.36-
146SuccinylationIPATILLKAKDILYR
EEHHHHHHHHHHHHH		50.36-
146SuccinylationIPATILLKAKDILYR
EEHHHHHHHHHHHHH		50.36-
183SuccinylationASQCPSLKTKLLVSD
HHHCCCCCCEEEECC		48.20-
183SuccinylationASQCPSLKTKLLVSD
HHHCCCCCCEEEECC		48.20-
184PhosphorylationSQCPSLKTKLLVSDH
HHCCCCCCEEEECCC		32.0246158131
189PhosphorylationLKTKLLVSDHSREGW
CCCEEEECCCCCCCC		29.5846158125
204AcetylationLDFRSLVKSASPEHT
CHHHHHHHHCCCCCC		45.67-
204SuccinylationLDFRSLVKSASPEHT
CHHHHHHHHCCCCCC		45.67-
204SuccinylationLDFRSLVKSASPEHT
CHHHHHHHHCCCCCC		45.67-
211PhosphorylationKSASPEHTCVKSKTL
HHCCCCCCCEECCCC		19.8246158137
214AcetylationSPEHTCVKSKTLDPM
CCCCCCEECCCCCCE		48.67-
227PhosphorylationPMVIFFTSGTTGFPK
CEEEEEECCCCCCHH		29.0523612710
237SuccinylationTGFPKMAKHSHGLAL
CCCHHHHHHCCCCCC		41.99-
237SuccinylationTGFPKMAKHSHGLAL
CCCHHHHHHCCCCCC		41.99-
331PhosphorylationILQQDFTSIRFPALE
HHHCCCCCCCCCCCC		16.2629496963
356SuccinylationPKDQEEWKRRTGLLL
CCCHHHHHHHHCEEE		34.97-
356SuccinylationPKDQEEWKRRTGLLL
CCCHHHHHHHHCEEE		34.97-
356AcetylationPKDQEEWKRRTGLLL
CCCHHHHHHHHCEEE		34.97-
391SuccinylationIKPGFMGKATPPYDV
ECCCCCCCCCCCCCE		36.98-
391AcetylationIKPGFMGKATPPYDV
ECCCCCCCCCCCCCE		36.98-
391SuccinylationIKPGFMGKATPPYDV
ECCCCCCCCCCCCCE		36.98-
421AcetylationGNIGIRIKPVRPVSL
CCCCEEEECCCEEEE		27.8419413330
439PhosphorylationYEGDPEKTAKVECGD
ECCCHHHCEEEEECC		30.0119413330
475PhosphorylationSDDIINASGYRIGPA
CCCCCCCCCEEECHH		31.6950563243
477PhosphorylationDIINASGYRIGPAEV
CCCCCCCEEECHHHH		9.1450563255
530PhosphorylationSHDKDQLTKELQQHV
CCCHHHHHHHHHHHH		19.4850563237
531AcetylationHDKDQLTKELQQHVK
CCHHHHHHHHHHHHH		66.09-
538AcetylationKELQQHVKSVTAPYK
HHHHHHHHHCCCCCC		36.76-
538SuccinylationKELQQHVKSVTAPYK
HHHHHHHHHCCCCCC		36.76-
538SuccinylationKELQQHVKSVTAPYK
HHHHHHHHHCCCCCC		36.76-
541PhosphorylationQQHVKSVTAPYKYPR
HHHHHHCCCCCCCCC		29.0750563249
544PhosphorylationVKSVTAPYKYPRKVE
HHHCCCCCCCCCCEE		22.2328857561
546PhosphorylationSVTAPYKYPRKVEFV
HCCCCCCCCCCEEEH		11.486867037
549AcetylationAPYKYPRKVEFVSEL
CCCCCCCCEEEHHCC		41.43-
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of ACSM1_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of ACSM1_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of ACSM1_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions

Oops, there are no PPI records of ACSM1_HUMAN !!
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of ACSM1_HUMAN

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Related Literatures of Post-Translational Modification

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