GBP5_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: GBP5_HUMAN
• UniProt AC: Q96PP8
• Protein Name: Guanylate-binding protein 5
• Gene Name: GBP5
• Organism: Homo sapiens (Human).
• Sequence Length: 586
• Subcellular Localization: Cytoplasm . Golgi apparatus membrane ; Lipid-anchor .
• Protein Description: As an activator of NLRP3 inflammasome assembly, plays a role in innate immunity and inflammation. Promotes selective NLRP3 inflammasome assembly in response to microbial and soluble, but not crystalline, agents. [PubMed: 22461501 Hydrolyzes GTP, but in contrast to other family members, does not produce GMP]
• Protein Sequence: MALEIHMSDPMCLIENFNEQLKVNQEALEILSAITQPVVVVAIVGLYRTGKSYLMNKLAGKNKGFSVASTVQSHTKGIWIWCVPHPNWPNHTLVLLDTEGLGDVEKADNKNDIQIFALALLLSSTFVYNTVNKIDQGAIDLLHNVTELTDLLKARNSPDLDRVEDPADSASFFPDLVWTLRDFCLGLEIDGQLVTPDEYLENSLRPKQGSDQRVQNFNLPRLCIQKFFPKKKCFIFDLPAHQKKLAQLETLPDDELEPEFVQQVTEFCSYIFSHSMTKTLPGGIMVNGSRLKNLVLTYVNAISSGDLPCIENAVLALAQRENSAAVQKAIAHYDQQMGQKVQLPMETLQELLDLHRTSEREAIEVFMKNSFKDVDQSFQKELETLLDAKQNDICKRNLEASSDYCSALLKDIFGPLEEAVKQGIYSKPGGHNLFIQKTEELKAKYYREPRKGIQAEEVLQKYLKSKESVSHAILQTDQALTETEKKKKEAQVKAEAEKAEAQRLAAIQRQNEQMMQERERLHQEQVRQMEIAKQNWLAEQQKMQEQQMQEQAAQLSTTFQAQNRSLLSELQHAQRTVNNDDPCVLL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
49	Phosphorylation	AIVGLYRTGKSYLMN EEEEHHHHCHHHHHH	35.09	23312004
52	Phosphorylation	GLYRTGKSYLMNKLA EHHHHCHHHHHHHHC	25.50	24719451
53	Phosphorylation	LYRTGKSYLMNKLAG HHHHCHHHHHHHHCC	17.29	23312004
66	Phosphorylation	AGKNKGFSVASTVQS CCCCCCCCHHHHCHH	25.99	27174698
69	Phosphorylation	NKGFSVASTVQSHTK CCCCCHHHHCHHCCC	27.27	27174698
70	Phosphorylation	KGFSVASTVQSHTKG CCCCHHHHCHHCCCC	16.90	27174698
73	Phosphorylation	SVASTVQSHTKGIWI CHHHHCHHCCCCEEE	28.87	27174698
75	Phosphorylation	ASTVQSHTKGIWIWC HHHCHHCCCCEEEEE	35.89	27174698
146	Phosphorylation	IDLLHNVTELTDLLK HHHHCHHHHHHHHHH	30.51	29978859
149	Phosphorylation	LHNVTELTDLLKARN HCHHHHHHHHHHHCC	20.54	29978859
157	Phosphorylation	DLLKARNSPDLDRVE HHHHHCCCCCHHCCC	17.78	27251275
226	Acetylation	LPRLCIQKFFPKKKC CCHHHHHHHCCCCCE	29.12	130243
333	Phosphorylation	VQKAIAHYDQQMGQK HHHHHHHHHHHCCCC	13.36	23401153
380	Ubiquitination	DVDQSFQKELETLLD CCCHHHHHHHHHHHH	63.36	29967540
389	Ubiquitination	LETLLDAKQNDICKR HHHHHHHHHCCHHHH	49.66	29967540
465	Phosphorylation	VLQKYLKSKESVSHA HHHHHHCCCCHHHHH	38.77	27251275
468	Phosphorylation	KYLKSKESVSHAILQ HHHCCCCHHHHHHHH	32.43	27251275
470	Phosphorylation	LKSKESVSHAILQTD HCCCCHHHHHHHHHH	19.24	27251275
533	Ubiquitination	VRQMEIAKQNWLAEQ HHHHHHHHHHHHHHH	50.23	29967540
565	Phosphorylation	TFQAQNRSLLSELQH HHHHHHHHHHHHHHH	41.01	24719451
568	Phosphorylation	AQNRSLLSELQHAQR HHHHHHHHHHHHHHH	41.37	29978859
583	Methylation	TVNNDDPCVLL---- HHCCCCCCCCC----	4.30	-
583	Geranylgeranylation	TVNNDDPCVLL---- HHCCCCCCCCC----	4.30	21151871
583	Geranylgeranylation	TVNNDDPCVLL---- HHCCCCCCCCC----	4.30	21151871

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of GBP5_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of GBP5_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of GBP5_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
GBP5_HUMAN	GBP5	physical	16189514
GBP1_HUMAN	GBP1	physical	28514442
ACSM1_HUMAN	ACSM1	physical	28514442
CA159_HUMAN	C1orf159	physical	28514442
APOL2_HUMAN	APOL2	physical	28514442
SURF1_HUMAN	SURF1	physical	28514442
EPHA4_HUMAN	EPHA4	physical	28514442

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.