PLCB_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: PLCB_HUMAN
• UniProt AC: O15120
• Protein Name: 1-acyl-sn-glycerol-3-phosphate acyltransferase beta
• Gene Name: AGPAT2
• Organism: Homo sapiens (Human).
• Sequence Length: 278
• Subcellular Localization: Endoplasmic reticulum membrane ; Multi-pass membrane protein .
• Protein Description: Converts lysophosphatidic acid (LPA) into phosphatidic acid by incorporating an acyl moiety at the sn-2 position of the glycerol backbone..
• Protein Sequence: MELWPCLAAALLLLLLLVQLSRAAEFYAKVALYCALCFTVSAVASLVCLLRHGGRTVENMSIIGWFVRSFKYFYGLRFEVRDPRRLQEARPCVIVSNHQSILDMMGLMEVLPERCVQIAKRELLFLGPVGLIMYLGGVFFINRQRSSTAMTVMADLGERMVRENLKVWIYPEGTRNDNGDLLPFKKGAFYLAVQAQVPIVPVVYSSFSSFYNTKKKFFTSGTVTVQVLEAIPTSGLTAADVPALVDTCHRAMRTTFLHISKTPQENGATAGSGVQPAQ

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
71	Ubiquitination	GWFVRSFKYFYGLRF HHHHHHHHHHHCCEE	35.38	-
72	Phosphorylation	WFVRSFKYFYGLRFE HHHHHHHHHHCCEEE	10.46	7331443
74	Phosphorylation	VRSFKYFYGLRFEVR HHHHHHHHCCEEEEC	16.50	7331453
146	Phosphorylation	FFINRQRSSTAMTVM EEEECCCCCCCHHHC	24.57	25954137
147	Phosphorylation	FINRQRSSTAMTVMA EEECCCCCCCHHHCH	23.52	25954137
148	Phosphorylation	INRQRSSTAMTVMAD EECCCCCCCHHHCHH	22.99	25954137
151	Phosphorylation	QRSSTAMTVMADLGE CCCCCCHHHCHHHHH	12.50	25954137
166	Ubiquitination	RMVRENLKVWIYPEG HHHHHCCEEEEECCC	47.29	21890473
167 (in isoform 1)	Ubiquitination	-	4.18	21890473
185	Ubiquitination	NGDLLPFKKGAFYLA CCCEECCCCCCEEEE	48.64	21890473
186 (in isoform 1)	Ubiquitination	-	56.71	21890473
186	Ubiquitination	GDLLPFKKGAFYLAV CCEECCCCCCEEEEE	56.71	-
220	Phosphorylation	TKKKFFTSGTVTVQV CCCCEECCCEEEEEE	27.58	46160457
224	Phosphorylation	FFTSGTVTVQVLEAI EECCCEEEEEEEEEC	12.69	22210691
229 (in isoform 2)	Ubiquitination	-	45.77	21906983
233	Phosphorylation	QVLEAIPTSGLTAAD EEEEECCCCCCCHHH	29.34	46160469
234	Phosphorylation	VLEAIPTSGLTAADV EEEECCCCCCCHHHH	26.84	22210691
237	Phosphorylation	AIPTSGLTAADVPAL ECCCCCCCHHHHHHH	24.27	46160475
261	Ubiquitination	TTFLHISKTPQENGA HHHEEEECCCCCCCC	64.72	2190698
262	Phosphorylation	TFLHISKTPQENGAT HHEEEECCCCCCCCC	24.34	50563993
262 (in isoform 1)	Ubiquitination	-	24.34	21890473
272	Phosphorylation	ENGATAGSGVQPAQ- CCCCCCCCCCCCCC-	33.07	50563999

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of PLCB_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of PLCB_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of PLCB_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
PHF11_HUMAN	PHF11	physical	21988832
S23A2_HUMAN	SLC23A2	physical	21988832
GUAA_HUMAN	GMPS	physical	21988832
ANR28_HUMAN	ANKRD28	physical	21988832
PHRF1_HUMAN	PHRF1	physical	21988832
H13_HUMAN	HIST1H1D	physical	26186194
H13_HUMAN	HIST1H1D	physical	28514442
INTU_HUMAN	INTU	physical	27173435

Drug and Disease Associations

• Kegg Disease
• H00419: Congenital generalized lipodystrophy (CGL)
• OMIM Disease
• 608594: Congenital generalized lipodystrophy 1 (CGL1)
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.