dbPTM

PPR3A_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	PPR3A_HUMAN
UniProt AC	Q16821
Protein Name	Protein phosphatase 1 regulatory subunit 3A
Gene Name	PPP1R3A
Organism	Homo sapiens (Human).
Sequence Length	1122
Subcellular Localization	Membrane Single-pass membrane protein.
Protein Description	Seems to act as a glycogen-targeting subunit for PP1. PP1 is essential for cell division, and participates in the regulation of glycogen metabolism, muscle contractility and protein synthesis. Plays an important role in glycogen synthesis but is not essential for insulin activation of glycogen synthase (By similarity)..
Protein Sequence	MEPSEVPSQISKDNFLEVPNLSDSLCEDEEVTFQPGFSPQPSRRGSDSSEDIYLDTPSSGTRRVSFADSFGFNLVSVKEFDCWELPSASTTFDLGTDIFHTEEYVLAPLFDLPSSKEDLMQQLQIQKAILESTESLLGSTSIKGIIRVLNVSFEKLVYVRMSLDDWQTHYDILAEYVPNSCDGETDQFSFKIVLVPPYQKDGSKVEFCIRYETSVGTFWSNNNGTNYTFICQKKEQEPEPVKPWKEVPNRQIKGCLKVKSSKEESSVTSEENNFENPKNTDTYIPTIICSHEDKEDLEASNRNVKDVNREHDEHNEKELELMINQHLIRTRSTASRDERNTFSTDPVNFPNKAEGLEKKQIHGEICTDLFQRSLSPSSSAESSVKGDFYCNEKYSSGDDCTHQPSEETTSNMGEIKPSLGDTSSDELVQLHTGSKEVLDDNANPAHGNGTVQIPCPSSDQLMAGNLNKKHEGGAKNIEVKDLGCLRRDFHSDTSACLKESTEEGSSKEDYYGNGKDDEEQRIYLGVNEKQRKNFQTILHDQERKMGNPKISVAGIGASNRDLATLLSEHTAIPTRAITADVSHSPRTNLSWEEAVLTPEHHHLTSEGSALGGITGQVCSSRTGNVLRNDYLFQVEEKSGGINSEDQDNSPQHKQSWNVLESQGKSRENKTNITEHIKGQTDCEDVWGKRDNTRSLKATTEELFTCQETVCCELSSLADHGITEKAEAGTAYIIKTTSESTPESMSAREKAIIAKLPQETARSDRPIEVKETAFDPHEGRNDDSHYTLCQRDTVGVIYDNDFEKESRLGICNVRVDEMEKEETMSMYNPRKTHDREKCGTGNITSVEESSWVITEYQKATSKLDLQLGMLPTDKTVFSENRDLRQVQELSKKTDSDAIVHSAFNSDTNRAPQNSSPFSKHHTEISVSTNEQAIAVENAVTTMASQPISTKSENICNSTREIQGIEKHPYPESKPEEVSRSSGIVTSGSRKERCIGQIFQTEEYSVEKSLGPMILINKPLENMEEARHENEGLVSSGQSLYTSGEKESDSSASTSLPVEESQAQGNESLFSKYTNSKIPYFLLFLIFLITVYHYDLMIGLTFYVLSLSWLSWEEGRQKESVKKK

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
38	Phosphorylation	VTFQPGFSPQPSRRG CCCCCCCCCCCCCCC	28.65	-
42	Phosphorylation	PGFSPQPSRRGSDSS CCCCCCCCCCCCCCC	29.39	-
46	Phosphorylation	PQPSRRGSDSSEDIY CCCCCCCCCCCCCEE	32.29	19764811
48	Phosphorylation	PSRRGSDSSEDIYLD CCCCCCCCCCCEEEE	37.01	22673903
49	Phosphorylation	SRRGSDSSEDIYLDT CCCCCCCCCCEEEEC	44.25	22673903
53	Phosphorylation	SDSSEDIYLDTPSSG CCCCCCEEEECCCCC	15.73	22673903
56	Phosphorylation	SEDIYLDTPSSGTRR CCCEEEECCCCCCCE	23.60	-
65	Phosphorylation	SSGTRRVSFADSFGF CCCCCEEEEEHHCCC	16.95	22817900
65	Dephosphorylation	SSGTRRVSFADSFGF CCCCCEEEEEHHCCC	16.95	2558013
69	Phosphorylation	RRVSFADSFGFNLVS CEEEEEHHCCCEEEE	24.68	22673903
189	Phosphorylation	DGETDQFSFKIVLVP CCCCCCCEEEEEEEC	21.72	24719451
198	Phosphorylation	KIVLVPPYQKDGSKV EEEEECCCCCCCCEE	23.33	26699800
203	Phosphorylation	PPYQKDGSKVEFCIR CCCCCCCCEEEEEEE	43.60	26699800
260	Phosphorylation	KGCLKVKSSKEESSV ECEEEECCCCCCCCC	50.02	26437602
266	Phosphorylation	KSSKEESSVTSEENN CCCCCCCCCCCCCCC	32.47	26437602
290	Phosphorylation	YIPTIICSHEDKEDL CCCEEEECCCCHHHH	21.36	25627689
330	Phosphorylation	INQHLIRTRSTASRD HHHHHHHCCCCCCCC	23.21	26437602
332	Phosphorylation	QHLIRTRSTASRDER HHHHHCCCCCCCCCC	27.93	29978859
333	Phosphorylation	HLIRTRSTASRDERN HHHHCCCCCCCCCCC	25.92	29978859
335	Phosphorylation	IRTRSTASRDERNTF HHCCCCCCCCCCCCC	40.11	29978859
367	Phosphorylation	QIHGEICTDLFQRSL CCCHHHHHHHHHHHC	41.20	27174698
373	Phosphorylation	CTDLFQRSLSPSSSA HHHHHHHHCCCCCCC	23.55	26437602
375	Phosphorylation	DLFQRSLSPSSSAES HHHHHHCCCCCCCCC	24.79	26437602
377	Phosphorylation	FQRSLSPSSSAESSV HHHHCCCCCCCCCCC	33.28	22673903
551	Phosphorylation	KMGNPKISVAGIGAS HHCCCCEEEEEECCC	16.43	26437602
567	Phosphorylation	RDLATLLSEHTAIPT HHHHHHHHCCCCCCC	30.37	28985074
578	Phosphorylation	AIPTRAITADVSHSP CCCCCCEECCCCCCC	18.80	28985074
584	Phosphorylation	ITADVSHSPRTNLSW EECCCCCCCCCCCCH	14.47	26437602
729	Phosphorylation	TEKAEAGTAYIIKTT CCCCCCCCEEEEEEC	24.28	30177828
731	Phosphorylation	KAEAGTAYIIKTTSE CCCCCCEEEEEECCC	11.74	30177828
735	Phosphorylation	GTAYIIKTTSESTPE CCEEEEEECCCCCCC	25.75	30177828
736	Phosphorylation	TAYIIKTTSESTPES CEEEEEECCCCCCCC	26.04	30177828
737	Phosphorylation	AYIIKTTSESTPESM EEEEEECCCCCCCCC	34.48	30177828
739	Phosphorylation	IIKTTSESTPESMSA EEEECCCCCCCCCCH	49.37	30177828
740	Phosphorylation	IKTTSESTPESMSAR EEECCCCCCCCCCHH	27.33	30177828
743	Phosphorylation	TSESTPESMSAREKA CCCCCCCCCCHHHHH	21.17	30177828
745	Phosphorylation	ESTPESMSAREKAII CCCCCCCCHHHHHHH	33.19	30177828
759	Phosphorylation	IAKLPQETARSDRPI HHHCCHHHHCCCCCE	23.32	21955146
822	Phosphorylation	DEMEKEETMSMYNPR HHCCHHHHHHHCCCC	18.68	25954137
824	Phosphorylation	MEKEETMSMYNPRKT CCHHHHHHHCCCCCC	26.07	25954137
826	Phosphorylation	KEETMSMYNPRKTHD HHHHHHHCCCCCCCC	18.08	25262027
839	Phosphorylation	HDREKCGTGNITSVE CCHHHCCCCCCEECE	36.20	28985074
844	Phosphorylation	CGTGNITSVEESSWV CCCCCCEECEECCEE	24.59	28387310
853	Phosphorylation	EESSWVITEYQKATS EECCEEEEEHHHHCC	21.01	28387310
855	Phosphorylation	SSWVITEYQKATSKL CCEEEEEHHHHCCCC	13.48	28985074
914	Phosphorylation	NRAPQNSSPFSKHHT CCCCCCCCCCCCCCC	37.20	26437602
939	Phosphorylation	IAVENAVTTMASQPI HEEEHHHHHHHCCCC	14.40	-
940	Phosphorylation	AVENAVTTMASQPIS EEEHHHHHHHCCCCC	12.25	-
979	Phosphorylation	KPEEVSRSSGIVTSG CCHHHHHCCCCCCCC	25.96	26437602
987	Phosphorylation	SGIVTSGSRKERCIG CCCCCCCCCHHCEEE	39.69	26437602
1033	Phosphorylation	HENEGLVSSGQSLYT HHCCCCCCCCCCCEE	33.52	25907765
1034	Phosphorylation	ENEGLVSSGQSLYTS HCCCCCCCCCCCEEC	33.11	25907765
1037	Phosphorylation	GLVSSGQSLYTSGEK CCCCCCCCCEECCCC	27.20	25907765
1039	Phosphorylation	VSSGQSLYTSGEKES CCCCCCCEECCCCCC	12.24	25907765
1040	Phosphorylation	SSGQSLYTSGEKESD CCCCCCEECCCCCCC	35.23	25907765
1041	Phosphorylation	SGQSLYTSGEKESDS CCCCCEECCCCCCCC	31.25	25907765
1066	Phosphorylation	SQAQGNESLFSKYTN HHHCCCHHHHHHHHC	38.42	-
1069	Phosphorylation	QGNESLFSKYTNSKI CCCHHHHHHHHCCCH	30.00	24719451

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
38	S	Phosphorylation	Kinase	GSK3	-	Uniprot
42	S	Phosphorylation	Kinase	GSK3	-	Uniprot
46	S	Phosphorylation	Kinase	RPS6KA3	P51812	GPS
46	S	Phosphorylation	Kinase	ISPK	-	Uniprot
46	S	Phosphorylation	Kinase	PKA	-	Uniprot
48	S	Phosphorylation	Kinase	RPS6KA1	Q15418	GPS
48	S	Phosphorylation	Kinase	PKA-FAMILY	-	GPS
48	S	Phosphorylation	Kinase	PKA_GROUP	-	PhosphoELM
65	S	Phosphorylation	Kinase	RPS6KA3	P51812	GPS
65	S	Phosphorylation	Kinase	PKA-FAMILY	-	GPS
65	S	Phosphorylation	Kinase	PKA	-	Uniprot
65	S	Phosphorylation	Kinase	PKA_GROUP	-	PhosphoELM

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
46	S	Phosphorylation		-
Phosphorylation at Ser-46 by ISPK stimulates the dephosphorylation of glycogen synthase and phosphorylase kinase.

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of PPR3A_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
BRCA1_HUMAN	BRCA1	physical	17511879
ASPP1_HUMAN	PPP1R13B	physical	24366813
ASPP2_HUMAN	TP53BP2	physical	24366813
CC85B_HUMAN	CCDC85B	physical	24366813
CC85C_HUMAN	CCDC85C	physical	24366813
CDCA2_HUMAN	CDCA2	physical	24366813
CNST_HUMAN	CNST	physical	24366813
CT027_HUMAN	C20orf27	physical	24366813
IASPP_HUMAN	PPP1R13L	physical	24366813
IPP2_HUMAN	PPP1R2	physical	24366813
KI18A_HUMAN	KIF18A	physical	24366813
KI67_HUMAN	MKI67	physical	24366813
ERBIN_HUMAN	ERBB2IP	physical	24366813
LMTK2_HUMAN	LMTK2	physical	24366813
NEB1_HUMAN	PPP1R9A	physical	24366813
NEB2_HUMAN	PPP1R9B	physical	24366813
NUP50_HUMAN	NUP50	physical	24366813
PDRG1_HUMAN	PDRG1	physical	24366813
PEAK1_HUMAN	PEAK1	physical	24366813
PFD2_HUMAN	PFDN2	physical	24366813
PFD6_HUMAN	PFDN6	physical	24366813
PIHD1_HUMAN	PIH1D1	physical	24366813
PP1A_HUMAN	PPP1CA	physical	24366813
PP1B_HUMAN	PPP1CB	physical	24366813
PP1R7_HUMAN	PPP1R7	physical	24366813
PP1R8_HUMAN	PPP1R8	physical	24366813
PP1RA_HUMAN	PPP1R10	physical	24366813
PP1RB_HUMAN	PPP1R11	physical	24366813
PP2BB_HUMAN	PPP3CB	physical	24366813
PPR18_HUMAN	PPP1R18	physical	24366813
RIF1_HUMAN	RIF1	physical	24366813
RMP_HUMAN	URI1	physical	24366813
RPAB1_HUMAN	POLR2E	physical	24366813
RPAP3_HUMAN	RPAP3	physical	24366813
RRP1B_HUMAN	RRP1B	physical	24366813
RUVB2_HUMAN	RUVBL2	physical	24366813
SCRIB_HUMAN	SCRIB	physical	24366813
SHOC2_HUMAN	SHOC2	physical	24366813
TOX4_HUMAN	TOX4	physical	24366813
TPRN_HUMAN	TPRN	physical	24366813
WDR82_HUMAN	WDR82	physical	24366813
WDR92_HUMAN	WDR92	physical	24366813
YLPM1_HUMAN	YLPM1	physical	24366813
ZFYV9_HUMAN	ZFYVE9	physical	24366813

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
125853	Diabetes mellitus, non-insulin-dependent (NIDDM)
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of PPR3A_HUMAN

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Global, in vivo, and site-specific phosphorylation dynamics insignaling networks."; Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P.,Mann M.; Cell 127:635-648(2006). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-759, AND MASSSPECTROMETRY.	17081983 [Abstract]

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