FZD10_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: FZD10_HUMAN
• UniProt AC: Q9ULW2
• Protein Name: Frizzled-10
• Gene Name: FZD10
• Organism: Homo sapiens (Human).
• Sequence Length: 581
• Subcellular Localization: Cell membrane ; Multi-pass membrane protein .
• Protein Description: Receptor for Wnt proteins. Functions in the canonical Wnt/beta-catenin signaling pathway (By similarity). The canonical Wnt/beta-catenin signaling pathway leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues (Probable)..
• Protein Sequence: MQRPGPRLWLVLQVMGSCAAISSMDMERPGDGKCQPIEIPMCKDIGYNMTRMPNLMGHENQREAAIQLHEFAPLVEYGCHGHLRFFLCSLYAPMCTEQVSTPIPACRVMCEQARLKCSPIMEQFNFKWPDSLDCRKLPNKNDPNYLCMEAPNNGSDEPTRGSGLFPPLFRPQRPHSAQEHPLKDGGPGRGGCDNPGKFHHVEKSASCAPLCTPGVDVYWSREDKRFAVVWLAIWAVLCFFSSAFTVLTFLIDPARFRYPERPIIFLSMCYCVYSVGYLIRLFAGAESIACDRDSGQLYVIQEGLESTGCTLVFLVLYYFGMASSLWWVVLTLTWFLAAGKKWGHEAIEANSSYFHLAAWAIPAVKTILILVMRRVAGDELTGVCYVGSMDVNALTGFVLIPLACYLVIGTSFILSGFVALFHIRRVMKTGGENTDKLEKLMVRIGLFSVLYTVPATCVIACYFYERLNMDYWKILAAQHKCKMNNQTKTLDCLMAASIPAVEIFMVKIFMLLVVGITSGMWIWTSKTLQSWQQVCSRRLKKKSRRKPASVITSGGIYKKAQHPQKTHHGKYEIPAQSPTCV

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
48	N-linked_Glycosylation	MCKDIGYNMTRMPNL CCCCCCCCCCCCCCC	21.82	UniProtKB CARBOHYD
145	Phosphorylation	PNKNDPNYLCMEAPN CCCCCCCCCCEECCC	13.48	-
153	N-linked_Glycosylation	LCMEAPNNGSDEPTR CCEECCCCCCCCCCC	50.73	UniProtKB CARBOHYD
155	Phosphorylation	MEAPNNGSDEPTRGS EECCCCCCCCCCCCC	40.71	-
159	Phosphorylation	NNGSDEPTRGSGLFP CCCCCCCCCCCCCCC	45.69	-
176	Phosphorylation	FRPQRPHSAQEHPLK CCCCCCCCCCCCCCC	34.04	27251275
485	N-linked_Glycosylation	QHKCKMNNQTKTLDC HHHHHCCCCCCHHHH	47.61	UniProtKB CARBOHYD
527	Phosphorylation	MWIWTSKTLQSWQQV CCHHCHHHHHHHHHH	29.78	24114839
530	Phosphorylation	WTSKTLQSWQQVCSR HCHHHHHHHHHHHHH	29.93	24114839
549	Phosphorylation	KSRRKPASVITSGGI HHCCCCCEEEECCCH	23.68	21945579
552	Phosphorylation	RKPASVITSGGIYKK CCCCEEEECCCHHHH	21.11	21945579
553	Phosphorylation	KPASVITSGGIYKKA CCCEEEECCCHHHHC	24.73	21945579
557	Phosphorylation	VITSGGIYKKAQHPQ EEECCCHHHHCCCCC	15.09	21945579
570	Ubiquitination	PQKTHHGKYEIPAQS CCCCCCCCEECCCCC	35.04	-
571	Phosphorylation	QKTHHGKYEIPAQSP CCCCCCCEECCCCCC	24.55	24719451
577	Phosphorylation	KYEIPAQSPTCV--- CEECCCCCCCCC---	25.04	21945579
579	Phosphorylation	EIPAQSPTCV----- ECCCCCCCCC-----	31.02	24719451

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of FZD10_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of FZD10_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of FZD10_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
EVI5_HUMAN	EVI5	physical	28514442
TMED8_HUMAN	TMED8	physical	28514442
GSTCD_HUMAN	GSTCD	physical	28514442
VPS8_HUMAN	VPS8	physical	28514442
ATRIP_HUMAN	ATRIP	physical	28514442
EVI5L_HUMAN	EVI5L	physical	28514442
VEZA_HUMAN	VEZT	physical	28514442
RINT1_HUMAN	RINT1	physical	28514442
CND1_HUMAN	NCAPD2	physical	28514442
XPO7_HUMAN	XPO7	physical	28514442
XPO4_HUMAN	XPO4	physical	28514442
VPP2_HUMAN	ATP6V0A2	physical	28514442
CD032_HUMAN	C4orf32	physical	28514442
TNPO2_HUMAN	TNPO2	physical	28514442
HEAT3_HUMAN	HEATR3	physical	28514442
THADA_HUMAN	THADA	physical	28514442
S39A1_HUMAN	SLC39A1	physical	28514442
IPO7_HUMAN	IPO7	physical	28514442
IPO11_HUMAN	IPO11	physical	28514442
CIP2A_HUMAN	KIAA1524	physical	28514442
MYADM_HUMAN	MYADM	physical	28514442
CND3_HUMAN	NCAPG	physical	28514442
IPO9_HUMAN	IPO9	physical	28514442
AT2B2_HUMAN	ATP2B2	physical	28514442
EI2BG_HUMAN	EIF2B3	physical	28514442
TNPO3_HUMAN	TNPO3	physical	28514442
TSN15_HUMAN	TSPAN15	physical	28514442
EI2BD_HUMAN	EIF2B4	physical	28514442
GLMN_HUMAN	GLMN	physical	28514442
EBP_HUMAN	EBP	physical	28514442
YIPF3_HUMAN	YIPF3	physical	28514442
ZW10_HUMAN	ZW10	physical	28514442
INT12_HUMAN	INTS12	physical	28514442
BTAF1_HUMAN	BTAF1	physical	28514442
SAAL1_HUMAN	SAAL1	physical	28514442
CAND2_HUMAN	CAND2	physical	28514442
DYM_HUMAN	DYM	physical	28514442
SMC2_HUMAN	SMC2	physical	28514442
VPP1_HUMAN	ATP6V0A1	physical	28514442
CND2_HUMAN	NCAPH	physical	28514442
NRP1_HUMAN	NRP1	physical	28514442
TBC9B_HUMAN	TBC1D9B	physical	28514442
GBB4_HUMAN	GNB4	physical	28514442
GEMI4_HUMAN	GEMIN4	physical	28514442
LEG1_HUMAN	LGALS1	physical	28514442
SETX_HUMAN	SETX	physical	28514442
CREL1_HUMAN	CRELD1	physical	28514442
EI2BE_HUMAN	EIF2B5	physical	28514442

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.