NGN3_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: NGN3_HUMAN
• UniProt AC: Q9Y4Z2
• Protein Name: Neurogenin-3
• Gene Name: NEUROG3
• Organism: Homo sapiens (Human).
• Sequence Length: 214
• Subcellular Localization: Nucleus .
• Protein Description: Acts as a transcriptional regulator. Together with NKX2-2, initiates transcriptional activation of NEUROD1. Involved in neurogenesis. Also required for the specification of a common precursor of the 4 pancreatic endocrine cell types (By similarity)..
• Protein Sequence: MTPQPSGAPTVQVTRETERSFPRASEDEVTCPTSAPPSPTRTRGNCAEAEEGGCRGAPRKLRARRGGRSRPKSELALSKQRRSRRKKANDRERNRMHNLNSALDALRGVLPTFPDDAKLTKIETLRFAHNYIWALTQTLRIADHSLYALEPPAPHCGELGSPGGSPGDWGSLYSPVSQAGSLSPAASLEERPGLLGATFSACLSPGSLAFSDFL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
73	Phosphorylation	GGRSRPKSELALSKQ CCCCCCHHHHHHHHH	40.29	28787133
112	Phosphorylation	ALRGVLPTFPDDAKL HHHCCCCCCCCCCCC	43.57	-
174	Phosphorylation	GDWGSLYSPVSQAGS CCHHHCCCCHHHCCC	24.90	-
183	Phosphorylation	VSQAGSLSPAASLEE HHHCCCCCCCCCHHC	17.75	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of NGN3_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of NGN3_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of NGN3_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
TFE2_HUMAN	TCF3	physical	28514442
ITF2_HUMAN	TCF4	physical	28514442
HTF4_HUMAN	TCF12	physical	28514442
TEP1_HUMAN	TEP1	physical	28514442
DCAF4_HUMAN	DCAF4	physical	28514442
ARI3B_HUMAN	ARID3B	physical	28514442
RMD2_HUMAN	RMDN2	physical	28514442
HES6_HUMAN	HES6	physical	28514442
ZN100_HUMAN	ZNF100	physical	28514442
YYAP1_HUMAN	YY1AP1	physical	28514442
ZN430_HUMAN	ZNF430	physical	28514442
RRP1_HUMAN	RRP1	physical	28514442
DHX35_HUMAN	DHX35	physical	28514442
ADCY6_HUMAN	ADCY6	physical	28514442
C1QBP_HUMAN	C1QBP	physical	28514442
ZN579_HUMAN	ZNF579	physical	28514442
NET1_HUMAN	NTN1	physical	28514442
TMTC4_HUMAN	TMTC4	physical	28514442
ID4_HUMAN	ID4	physical	28514442
HERC1_HUMAN	HERC1	physical	28514442
ZN496_HUMAN	ZNF496	physical	28514442
DHX57_HUMAN	DHX57	physical	28514442
ZN638_HUMAN	ZNF638	physical	28514442
RMD3_HUMAN	RMDN3	physical	28514442
PHF10_HUMAN	PHF10	physical	28514442
GXLT2_HUMAN	GXYLT2	physical	28514442
CC71L_HUMAN	CCDC71L	physical	28514442
EME1_HUMAN	EME1	physical	28514442
FBRL_HUMAN	FBL	physical	28514442
RECQ4_HUMAN	RECQL4	physical	28514442
TEX10_HUMAN	TEX10	physical	28514442
SETX_HUMAN	SETX	physical	28514442
RTEL1_HUMAN	RTEL1	physical	28514442
NOP56_HUMAN	NOP56	physical	28514442
ZN593_HUMAN	ZNF593	physical	28514442
MYO9B_HUMAN	MYO9B	physical	28514442
ASPM_HUMAN	ASPM	physical	28514442
TF3C2_HUMAN	GTF3C2	physical	28514442
DDX51_HUMAN	DDX51	physical	28514442
F207A_HUMAN	FAM207A	physical	28514442
DDX56_HUMAN	DDX56	physical	28514442

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.