| UniProt ID | KC1E_MOUSE | |
|---|---|---|
| UniProt AC | Q9JMK2 | |
| Protein Name | Casein kinase I isoform epsilon | |
| Gene Name | Csnk1e | |
| Organism | Mus musculus (Mouse). | |
| Sequence Length | 416 | |
| Subcellular Localization | Cytoplasm. Nucleus . | |
| Protein Description | Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. Can phosphorylate a large number of proteins. Participates in Wnt signaling. Phosphorylates DVL1. Central component of the circadian clock. In balance with PP1, determines the circadian period length, through the regulation of the speed and rhythmicity of PER1 and PER2 phosphorylation. Controls PER1 and PER2 nuclear transport and degradation. Inhibits cytokine-induced granuloytic differentiation.. | |
| Protein Sequence | MELRVGNKYRLGRKIGSGSFGDIYLGANIASGEEVAIKLECVKTKHPQLHIESKFYKMMQGGVGIPSIKWCGAEGDYNVMVMELLGPSLEDLFNFCSRKFSLKTVLLLADQMISRIEYIHSKNFIHRDVKPDNFLMGLGKKGNLVYIIDFGLAKKYRDARTHQHIPYRENKNLTGTARYASINTHLGIEQSRRDDLESLGYVLMYFNLGSLPWQGLKAATKRQKYERISEKKMSTPIEVLCKGYPSEFSTYLNFCRSLRFDDKPDYSYLRQLFRNLFHRQGFSYDYVFDWNMLKFGAARNPEDVDRERREHEREERMGQLRGSATRALPPGPPTGATANRLRSAAEPVASTPASRIQQTGNTSPRAISRADRERKVSMRLHRGAPANVSSSDLTGRQEVSRLAASQTSVPFDHLGK | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 67 | Phosphorylation | QGGVGIPSIKWCGAE CCCCCCCCCCCCCCC | 34.57 | 23375375 | |
| 101 | Phosphorylation | NFCSRKFSLKTVLLL HHHCCCCCHHHHHHH | 31.80 | 23140645 | |
| 140 | Ubiquitination | NFLMGLGKKGNLVYI CEEECCCCCCCEEEE | 63.65 | - | |
| 263 | Ubiquitination | RSLRFDDKPDYSYLR HHCCCCCCCCHHHHH | 41.45 | - | |
| 323 | Phosphorylation | RMGQLRGSATRALPP HHHHHCCCCCCCCCC | 21.74 | 29514104 | |
| 325 | Phosphorylation | GQLRGSATRALPPGP HHHCCCCCCCCCCCC | 20.40 | - | |
| 343 | Phosphorylation | ATANRLRSAAEPVAS HHHHHHHHCCCCCCC | 36.10 | 26824392 | |
| 350 | Phosphorylation | SAAEPVASTPASRIQ HCCCCCCCCCHHHHH | 34.85 | 29514104 | |
| 354 | Phosphorylation | PVASTPASRIQQTGN CCCCCCHHHHHCCCC | 30.99 | 29514104 | |
| 359 | Phosphorylation | PASRIQQTGNTSPRA CHHHHHCCCCCCHHH | 18.94 | 29472430 | |
| 362 | Phosphorylation | RIQQTGNTSPRAISR HHHCCCCCCHHHHHH | 41.26 | 27087446 | |
| 363 | Phosphorylation | IQQTGNTSPRAISRA HHCCCCCCHHHHHHH | 19.18 | 25521595 | |
| 382 | Methylation | KVSMRLHRGAPANVS HHHHHHCCCCCCCCC | 47.78 | 24129315 | |
| 389 | Phosphorylation | RGAPANVSSSDLTGR CCCCCCCCHHHCCCH | 24.75 | 25521595 | |
| 390 | Phosphorylation | GAPANVSSSDLTGRQ CCCCCCCHHHCCCHH | 24.48 | 25619855 | |
| 391 | Phosphorylation | APANVSSSDLTGRQE CCCCCCHHHCCCHHH | 29.18 | 25619855 | |
| 394 | Phosphorylation | NVSSSDLTGRQEVSR CCCHHHCCCHHHHHH | 35.00 | 28066266 | |
| 400 | Phosphorylation | LTGRQEVSRLAASQT CCCHHHHHHHHHHCC | 22.33 | 26643407 | |
| 405 | Phosphorylation | EVSRLAASQTSVPFD HHHHHHHHCCCCCCC | 28.52 | 27087446 | |
| 407 | Phosphorylation | SRLAASQTSVPFDHL HHHHHHCCCCCCCCC | 29.24 | 27087446 | |
| 408 | Phosphorylation | RLAASQTSVPFDHLG HHHHHCCCCCCCCCC | 21.84 | 27087446 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of KC1E_MOUSE !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of KC1E_MOUSE !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of KC1E_MOUSE !! | ||||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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