CRYL1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CRYL1_HUMAN
• UniProt AC: Q9Y2S2
• Protein Name: Lambda-crystallin homolog
• Gene Name: CRYL1
• Organism: Homo sapiens (Human).
• Sequence Length: 319
• Subcellular Localization: Cytoplasm.
• Protein Sequence: MASSAAGCVVIVGSGVIGRSWAMLFASGGFQVKLYDIEQQQIRNALENIRKEMKLLEQAGSLKGSLSVEEQLSLISGCPNIQEAVEGAMHIQECVPEDLELKKKIFAQLDSIIDDRVILSSSTSCLMPSKLFAGLVHVKQCIVAHPVNPPYYIPLVELVPHPETAPTTVDRTHALMKKIGQCPMRVQKEVAGFVLNRLQYAIISEAWRLVEEGIVSPSDLDLVMSEGLGMRYAFIGPLETMHLNAEGMLSYCDRYSEGIKHVLQTFGPIPEFSRATAEKVNQDMCMKVPDDPEHLAARRQWRDECLMRLAKLKSQVQPQ

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MASSAAGCV ------CCCCCCCEE	16.52	-
3	Phosphorylation	-----MASSAAGCVV -----CCCCCCCEEE	21.15	-
20	Phosphorylation	GSGVIGRSWAMLFAS CCCCCCHHHHHHHHC	17.61	29978859
27	Phosphorylation	SWAMLFASGGFQVKL HHHHHHHCCCEEEEE	31.92	24043423
35	Phosphorylation	GGFQVKLYDIEQQQI CCEEEEEEEHHHHHH	14.79	17053785
111	Phosphorylation	KIFAQLDSIIDDRVI HHHHHHHHHCCCEEE	30.00	15489334
121	Phosphorylation	DDRVILSSSTSCLMP CCEEEECCCCCCCCC	33.90	28857561
122	Phosphorylation	DRVILSSSTSCLMPS CEEEECCCCCCCCCC	22.44	28857561
123	Phosphorylation	RVILSSSTSCLMPSK EEEECCCCCCCCCCH	25.96	28857561
124	Phosphorylation	VILSSSTSCLMPSKL EEECCCCCCCCCCHH	13.75	28857561
129	Phosphorylation	STSCLMPSKLFAGLV CCCCCCCCHHHCCCE	28.20	22617229
166 (in isoform 2)	Ubiquitination	-	35.70	21906983
188	Ubiquitination	QCPMRVQKEVAGFVL CCCHHHHHHHHHHHH	51.83	2190698
188 (in isoform 1)	Ubiquitination	-	51.83	21906983
200	Phosphorylation	FVLNRLQYAIISEAW HHHHHHHHHHHHHHH	12.36	-
279	Ubiquitination	FSRATAEKVNQDMCM HHHHHHHHHCHHHHH	43.98	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of CRYL1_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of CRYL1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CRYL1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
PAR1_HUMAN	F2R	physical	28514442
PKD2_HUMAN	PKD2	physical	28514442
TRI65_HUMAN	TRIM65	physical	28514442
HD_HUMAN	HTT	physical	28514442
SPTCS_HUMAN	SPG11	physical	28514442
APC5_HUMAN	ANAPC5	physical	28514442
CE034_HUMAN	C5orf34	physical	28514442
DYHC2_HUMAN	DYNC2H1	physical	28514442
SMG7_HUMAN	SMG7	physical	28514442
HAUS5_HUMAN	HAUS5	physical	28514442
UBP19_HUMAN	USP19	physical	28514442
CE164_HUMAN	CEP164	physical	28514442
P3C2A_HUMAN	PIK3C2A	physical	28514442
IF122_HUMAN	IFT122	physical	28514442
CDC23_HUMAN	CDC23	physical	28514442
TBCD_HUMAN	TBCD	physical	28514442
STIL_HUMAN	STIL	physical	28514442
IF140_HUMAN	IFT140	physical	28514442
UBR4_HUMAN	UBR4	physical	28514442
SMG8_HUMAN	SMG8	physical	28514442
ALMS1_HUMAN	ALMS1	physical	28514442
HAUS3_HUMAN	HAUS3	physical	28514442
MYO9A_HUMAN	MYO9A	physical	28514442
WDR59_HUMAN	WDR59	physical	28514442
TTC37_HUMAN	TTC37	physical	28514442
WAP53_HUMAN	WRAP53	physical	28514442
HOOK1_HUMAN	HOOK1	physical	28514442
APC1_HUMAN	ANAPC1	physical	28514442
FANCJ_HUMAN	BRIP1	physical	28514442
UBP54_HUMAN	USP54	physical	28514442
PLD2_HUMAN	PLD2	physical	28514442
TRI32_HUMAN	TRIM32	physical	28514442
MYO5C_HUMAN	MYO5C	physical	28514442
E2AK4_HUMAN	EIF2AK4	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.