dbPTM

CLN8_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	CLN8_HUMAN
UniProt AC	Q9UBY8
Protein Name	Protein CLN8
Gene Name	CLN8
Organism	Homo sapiens (Human).
Sequence Length	286
Subcellular Localization	Endoplasmic reticulum membrane Multi-pass membrane protein . Endoplasmic reticulum-Golgi intermediate compartment membrane Multi-pass membrane protein . Endoplasmic reticulum .
Protein Description	Could play a role in cell proliferation during neuronal differentiation and in protection against cell death..
Protein Sequence	MNPASDGGTSESIFDLDYASWGIRSTLMVAGFVFYLGVFVVCHQLSSSLNATYRSLVAREKVFWDLAATRAVFGVQSTAAGLWALLGDPVLHADKARGQQNWCWFHITTATGFFCFENVAVHLSNLIFRTFDLFLVIHHLFAFLGFLGCLVNLQAGHYLAMTTLLLEMSTPFTCVSWMLLKAGWSESLFWKLNQWLMIHMFHCRMVLTYHMWWVCFWHWDGLVSSLYLPHLTLFLVGLALLTLIINPYWTHKKTQQLLNPVDWNFAQPEAKSRPEGNGQLLRKKRP

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
55	Phosphorylation	SLNATYRSLVAREKV HCCHHHHHHHHHHHH	19.44	22210691
69	Phosphorylation	VFWDLAATRAVFGVQ HHHHHHHHHHHHCCC	17.35	22210691
78	Phosphorylation	AVFGVQSTAAGLWAL HHHCCCCHHHHHHHH	11.93	22210691

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of CLN8_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of CLN8_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of CLN8_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
VAPA_HUMAN	VAPA	physical	23142642
ERG28_HUMAN	C14orf1	physical	23142642
STX8_HUMAN	STX8	physical	23142642
GBRL2_HUMAN	GABARAPL2	physical	23142642
BNIP3_HUMAN	BNIP3	physical	23142642
BNI3L_HUMAN	BNIP3L	physical	23142642
PDIA6_HUMAN	PDIA6	physical	23142642
RTN4_HUMAN	RTN4	physical	23142642
PRAF3_HUMAN	ARL6IP5	physical	23142642
CD9_HUMAN	CD9	physical	23142642
MTX1_HUMAN	MTX1	physical	23142642
NDRG2_HUMAN	NDRG2	physical	23142642
TBB4A_HUMAN	TUBB4A	physical	23142642
CYB5B_HUMAN	CYB5B	physical	23142642
RRP15_HUMAN	RRP15	physical	23142642
PTPRN_HUMAN	PTPRN	physical	23142642
GPM6B_HUMAN	GPM6B	physical	23142642
SELK_HUMAN	SELK	physical	23142642
SPCS2_HUMAN	SPCS2	physical	23142642
MYPR_HUMAN	PLP1	physical	23142642
UBC_HUMAN	UBC	physical	23142642
PLP2_HUMAN	PLP2	physical	23142642
YIPF6_HUMAN	YIPF6	physical	23142642
ZUFSP_HUMAN	ZUFSP	physical	23142642
TMM11_HUMAN	TMEM11	physical	23142642
TM14A_HUMAN	TMEM14A	physical	23142642
TM107_HUMAN	TMEM107	physical	23142642
TM128_HUMAN	TMEM128	physical	23142642
TM134_HUMAN	TMEM134	physical	23142642
TM147_HUMAN	TMEM147	physical	23142642

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of CLN8_HUMAN

Related Literatures of Post-Translational Modification