TM134_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: TM134_HUMAN
• UniProt AC: Q9H6X4
• Protein Name: Transmembrane protein 134
• Gene Name: TMEM134
• Organism: Homo sapiens (Human).
• Sequence Length: 195
• Subcellular Localization: Membrane ; Multi-pass membrane protein . Cytoplasm, perinuclear region .
• Protein Sequence: MSAARPQFSIDDAFELSLEDGGPGPESSGVARFGPLHFERRARFEVADEDKQSRLRYQNLENDEDGAQASPEPDGGVGTRDSSRTSIRSSQWSFSTISSSTQRSYNTCCSWTQHPLIQKNRRVVLASFLLLLLGLVLILVGVGLEATPSPGVSSAIFFVPGFLLLVPGVYHVIFIYCAVKGHRGFQFFYLPYFEK

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
9	Phosphorylation	SAARPQFSIDDAFEL CCCCCCCCCCCCEEE	21.62	28348404
17	Phosphorylation	IDDAFELSLEDGGPG CCCCEEEECCCCCCC	23.63	28348404
53	Phosphorylation	VADEDKQSRLRYQNL ECCCCHHHHHHHHCC	38.74	25849741
57	Phosphorylation	DKQSRLRYQNLENDE CHHHHHHHHCCCCCC	13.32	21945579
70	Phosphorylation	DEDGAQASPEPDGGV CCCCCCCCCCCCCCC	20.09	25849741
82	Phosphorylation	GGVGTRDSSRTSIRS CCCCCCCCCCCCCHH	20.59	28102081
83	Phosphorylation	GVGTRDSSRTSIRSS CCCCCCCCCCCCHHC	43.81	28102081
85	Phosphorylation	GTRDSSRTSIRSSQW CCCCCCCCCCHHCCE	30.38	28102081
86	Phosphorylation	TRDSSRTSIRSSQWS CCCCCCCCCHHCCEE	18.20	28102081
89	Phosphorylation	SSRTSIRSSQWSFST CCCCCCHHCCEEEEE	25.80	30108239
90	Phosphorylation	SRTSIRSSQWSFSTI CCCCCHHCCEEEEEC	26.31	30108239
93	Phosphorylation	SIRSSQWSFSTISSS CCHHCCEEEEECCCC	11.15	26657352
95	Phosphorylation	RSSQWSFSTISSSTQ HHCCEEEEECCCCCC	21.22	25072903
96	Phosphorylation	SSQWSFSTISSSTQR HCCEEEEECCCCCCC	23.91	30108239
98	Phosphorylation	QWSFSTISSSTQRSY CEEEEECCCCCCCCC	20.51	25072903
99	Phosphorylation	WSFSTISSSTQRSYN EEEEECCCCCCCCCC	33.29	27080861

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of TM134_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of TM134_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of TM134_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of TM134_HUMAN !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.