PCDA3_HUMAN - dbPTM
PCDA3_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID PCDA3_HUMAN
UniProt AC Q9Y5H8
Protein Name Protocadherin alpha-3
Gene Name PCDHA3
Organism Homo sapiens (Human).
Sequence Length 950
Subcellular Localization Cell membrane
Single-pass type I membrane protein.
Protein Description Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain..
Protein Sequence MLFSWREDPGAQCLLLSLLLLAASEVGSGQLHYSVSEEAKHGTFVGRIAQDLGLELAELVPRLFRVASKRHGDLLEVNLQNGILFVNSRIDREELCGRSAECSIHLEVIVDRPLQVFHVEVEVKDINDNAPVFPMAVKNLFISESRQPGSRFSLEGASDADIGTNSLLTYSLDSTEYFTLDVKRNDEEIKSLGLVLKKNLNREDTPKHYLLITAIDGGKPELTGTTQLKITVLDVNDNAPAFERTIYKVRLLENAPNGTLVVTVNATDLDEGVNKDIAYSFNTDMSADILSKFHLDPVNGQISVKGNIDFEESKSYEIQVEATDKGNPPMSDHCTVLLEIVDINDNVPELVIQSLSLPVLEDSPLSTVIALISVSDRDSGVNGQVTCSLTPHVPFKLVSTFKNYYSLVLDSPLDRESVSAYELVVTARDGGSPSLWATASVSVEVADVNDNAPAFSQSEYTVFVKENNPPGCHIFTVSARDADAQENALVSYSLVERRVGERALSSYVSVHAESGKVYALQPLDHEELELLQFQVSARDAGVPPLGSNVTLQVFVLDENDNAPALLMPRVGGIGGAVSELVPRSVGAGHVVAKVRAVDADSGYNAWLSYELQPGTGGARIPFRVGLYTGEISTTRALDEVDAPRHRLLVLVKDHGEPSLTATATVLVSLVESGQAPKASSQASAGATGPEAALVDVNVYLIVAICAVSSLLVLTLLLYTALRCSAPPTEGDCGPGKPTLVCSSAVGSWSYSQQRQQRVCSGEGLPKTDLMAFSPSLPPCPISRDREEKQDVDVDLSAKPRQPNPDWRYSASLRAGMHSSVHLEEAGILRAGPGGPDQQWPTVSSATPEPEAGEVSPPVGAGVNSNSWTFKYGPGNPKQSGPGELPDKFIIPGSPAIISIRQEPTNSQIDKSDFITFGKKEETKKKKKKKKGNKTQEKKEKGNSTTDNSDQ
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
153PhosphorylationRQPGSRFSLEGASDA
CCCCCCCEECCCCCC		25.1322210691
175PhosphorylationLTYSLDSTEYFTLDV
EEEECCCCCEEEEEC		34.0822210691
191PhosphorylationRNDEEIKSLGLVLKK
CCHHHHHHHHEEEEC		33.07-
257N-linked_GlycosylationRLLENAPNGTLVVTV
EEHHCCCCCEEEEEE		54.38UniProtKB CARBOHYD
265N-linked_GlycosylationGTLVVTVNATDLDEG
CEEEEEECCCCCCCC		27.97UniProtKB CARBOHYD
432PhosphorylationVTARDGGSPSLWATA
EEECCCCCCCEEEEE		19.49-
506PhosphorylationVGERALSSYVSVHAE
HHHHHHHHEEEEEEC		30.33-
514PhosphorylationYVSVHAESGKVYALQ
EEEEEECCCCEEEEC		44.7029759185
548N-linked_GlycosylationGVPPLGSNVTLQVFV
CCCCCCCCEEEEEEE		29.06UniProtKB CARBOHYD
601PhosphorylationVRAVDADSGYNAWLS
EEEEECCCCCCEEEE		44.9218187866
603PhosphorylationAVDADSGYNAWLSYE
EEECCCCCCEEEEEE		12.9822817900
747PhosphorylationVCSSAVGSWSYSQQR
EEECCCCCCCHHHHH		13.2728857561
750PhosphorylationSAVGSWSYSQQRQQR
CCCCCCCHHHHHHHH		12.3028857561
751PhosphorylationAVGSWSYSQQRQQRV
CCCCCCHHHHHHHHH		17.8328857561
775PhosphorylationDLMAFSPSLPPCPIS
HHCCCCCCCCCCCCC		52.92-
808PhosphorylationQPNPDWRYSASLRAG
CCCCCCCCEEHHHCC		12.34-
809PhosphorylationPNPDWRYSASLRAGM
CCCCCCCEEHHHCCC		11.6524719451
811PhosphorylationPDWRYSASLRAGMHS
CCCCCEEHHHCCCCC		16.6724719451
818PhosphorylationSLRAGMHSSVHLEEA
HHHCCCCCCEEHHHC		25.7628857561
819PhosphorylationLRAGMHSSVHLEEAG
HHCCCCCCEEHHHCC		10.0124719451
877UbiquitinationKYGPGNPKQSGPGEL
ECCCCCCCCCCCCCC		62.1833845483
893PhosphorylationDKFIIPGSPAIISIR
CCEEECCCCEEEEEE		13.0527050516
898PhosphorylationPGSPAIISIRQEPTN
CCCCEEEEEECCCCC		12.9527732954
904PhosphorylationISIRQEPTNSQIDKS
EEEECCCCCCCCCHH		46.91-
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of PCDA3_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of PCDA3_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of PCDA3_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
PCDA6_HUMANPCDHA6physical
28514442
PCDA9_HUMANPCDHA9physical
28514442
PCDA1_HUMANPCDHA1physical
28514442
PCDAB_HUMANPCDHA11physical
28514442
ABHD6_HUMANABHD6physical
28514442
KCNT2_HUMANKCNT2physical
28514442
DCMC_HUMANMLYCDphysical
28514442
AT132_HUMANATP13A2physical
28514442
PCDGL_HUMANPCDHGC4physical
28514442
NSMA_HUMANSMPD2physical
28514442
CSCL2_HUMANTMEM63Bphysical
28514442
ABCD4_HUMANABCD4physical
28514442
GAS6_HUMANGAS6physical
28514442
AT2A3_HUMANATP2A3physical
28514442
CNOT9_HUMANRQCD1physical
28514442
ABCB9_HUMANABCB9physical
28514442
RPP29_HUMANPOP4physical
28514442
DHRS7_HUMANDHRS7physical
28514442
TYW1_HUMANTYW1physical
28514442
S12A4_HUMANSLC12A4physical
28514442
CP51A_HUMANCYP51A1physical
28514442
NGBR_HUMANNUS1physical
28514442
PIGA_HUMANPIGAphysical
28514442
CA043_HUMANC1orf43physical
28514442
MYCB2_HUMANMYCBP2physical
28514442
RETST_HUMANRETSATphysical
28514442
GHDC_HUMANGHDCphysical
28514442
F136A_HUMANFAM136Aphysical
28514442
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of PCDA3_HUMAN

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Related Literatures of Post-Translational Modification

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