PCDA6_HUMAN - dbPTM
PCDA6_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID PCDA6_HUMAN
UniProt AC Q9UN73
Protein Name Protocadherin alpha-6
Gene Name PCDHA6
Organism Homo sapiens (Human).
Sequence Length 950
Subcellular Localization Isoform 1: Cell membrane
Single-pass type I membrane protein.
Isoform 2: Secreted .
Protein Description Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain..
Protein Sequence MVFTPEDRLGKQCLLLPLLLLAAWKVGSGQLHYSVPEEAKHGTFVGRIAQDLGLELAELVPRLFRMASKDREDLLEVNLQNGILFVNSRIDREELCGRSAECSIHLEVIVDRPLQVFHVDVEVRDINDNPPLFPVEEQRVLIYESRLPDSVFPLEGASDADVGSNSILTYKLSSSEYFGLDVKINSDDNKQIGLLLKKSLDREEAPAHNLFLTATDGGKPELTGTVQLLVTVLDVNDNAPTFEQSEYEVRIFENADNGTTVIRLNASDRDEGANGAISYSFNSLVAAMVIDHFSIDRNTGEIVIRGNLDFEQENLYKILIDATDKGHPPMAGHCTVLVRILDKNDNVPEIALTSLSLPVREDAQFGTVIALISVNDLDSGANGQVNCSLTPHVPFKLVSTFKNYYSLVLDSALDRESVSAYELVVTARDGGSPSLWATASLSVEVADMNDNAPAFAQPEYTVFVKENNPPGCHIFTVSARDADAQENALVSYSLVERRVGERALSSYISVHAESGKVYALQPLDHEELELLQFQVSARDAGVPPLGSNVTLQVFVLDENDNAPALLAPRVGGTGGAVSELVPRSLGAGQVVAKVRAVDADSGYNAWLSYELQPPASSARFPFRVGLYTGEISTTRVLDEADSPRHRLLVLVKDHGEPALTATATVLVSLVESGQAPKASSRASVGAAGPEAALVDVNVYLIIAICAVSSLLVLTLLLYTALRCSAPPTEGACTADKPTLVCSSAVGSWSYSQQRRQRVCSGEGPPKMDLMAFSPSLSPCPIMMGKAENQDLNEDHDAKPRQPNPDWRYSASLRAGMHSSVHLEEAGILRAGPGGPDQQWPTVSSATPEPEAGEVSPPVGAGVNSNSWTFKYGPGNPKQSGPGELPDKFIIPGSPAIISIRQEPTNSQIDKSDFITFGKKEETKKKKKKKKGNKTQEKKEKGNSTTDNSDQ
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
33PhosphorylationVGSGQLHYSVPEEAK
HCCCCCCCCCCHHHC		21.69-
143PhosphorylationEEQRVLIYESRLPDS
HHEEEEEEECCCCCC		12.0521394647
257N-linked_GlycosylationRIFENADNGTTVIRL
EEEECCCCCCEEEEE		47.50UniProtKB CARBOHYD
265N-linked_GlycosylationGTTVIRLNASDRDEG
CCEEEEECCCCCCCC		27.78UniProtKB CARBOHYD
356PhosphorylationEIALTSLSLPVREDA
EEEEEECCCCHHCCC		30.3224945436
386N-linked_GlycosylationSGANGQVNCSLTPHV
CCCCCEEEEEECCCC		11.19UniProtKB CARBOHYD
432PhosphorylationVTARDGGSPSLWATA
EEECCCCCCCEEEEE		19.49-
505PhosphorylationRVGERALSSYISVHA
HHHHHHHHHEEEEEE		21.8027251275
506PhosphorylationVGERALSSYISVHAE
HHHHHHHHEEEEEEC		27.6027251275
507PhosphorylationGERALSSYISVHAES
HHHHHHHEEEEEECC		8.2127251275
509PhosphorylationRALSSYISVHAESGK
HHHHHEEEEEECCCC		10.3027251275
514PhosphorylationYISVHAESGKVYALQ
EEEEEECCCCEEEEC		44.7027251275
548N-linked_GlycosylationGVPPLGSNVTLQVFV
CCCCCCCCEEEEEEE		29.06UniProtKB CARBOHYD
601PhosphorylationVRAVDADSGYNAWLS
EEEEECCCCCCEEEE		44.9218187866
603PhosphorylationAVDADSGYNAWLSYE
EEECCCCCCEEEEEE		12.9822817900
613UbiquitinationWLSYELQPPASSARF
EEEEEECCCCCCCCC		38.7633845483
616PhosphorylationYELQPPASSARFPFR
EEECCCCCCCCCCEE		30.2418187866
617PhosphorylationELQPPASSARFPFRV
EECCCCCCCCCCEEE		26.1018187866
629PhosphorylationFRVGLYTGEISTTRV
EEEEEEECCEEEEEE		19.3832142685
660PhosphorylationDHGEPALTATATVLV
CCCCCCCEEEEEEHH		24.86-
662PhosphorylationGEPALTATATVLVSL
CCCCCEEEEEEHHHH		20.02-
664PhosphorylationPALTATATVLVSLVE
CCCEEEEEEHHHHHH		15.26-
679PhosphorylationSGQAPKASSRASVGA
CCCCCCCCCCCCCCC		26.87-
680PhosphorylationGQAPKASSRASVGAA
CCCCCCCCCCCCCCC		36.40-
747PhosphorylationVCSSAVGSWSYSQQR
EEECCCCCCCHHHHH		13.2722210691
749PhosphorylationSSAVGSWSYSQQRRQ
ECCCCCCCHHHHHHH		19.3222210691
750PhosphorylationSAVGSWSYSQQRRQR
CCCCCCCHHHHHHHH		12.3028857561
751PhosphorylationAVGSWSYSQQRRQRV
CCCCCCHHHHHHHHH		17.8328857561
760PhosphorylationQRRQRVCSGEGPPKM
HHHHHHHCCCCCCCC		36.7028348404
808PhosphorylationQPNPDWRYSASLRAG
CCCCCCCCEEHHHCC		12.34-
809PhosphorylationPNPDWRYSASLRAGM
CCCCCCCEEHHHCCC		11.6524719451
811PhosphorylationPDWRYSASLRAGMHS
CCCCCEEHHHCCCCC		16.6724719451
818PhosphorylationSLRAGMHSSVHLEEA
HHHCCCCCCEEHHHC		25.7628857561
819PhosphorylationLRAGMHSSVHLEEAG
HHCCCCCCEEHHHCC		10.0124719451
877UbiquitinationKYGPGNPKQSGPGEL
ECCCCCCCCCCCCCC		62.1833845483
893PhosphorylationDKFIIPGSPAIISIR
CCEEECCCCEEEEEE		13.0527050516
898PhosphorylationPGSPAIISIRQEPTN
CCCCEEEEEECCCCC		12.9527732954
904PhosphorylationISIRQEPTNSQIDKS
EEEECCCCCCCCCHH		46.91-
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of PCDA6_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of PCDA6_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of PCDA6_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions

Oops, there are no PPI records of PCDA6_HUMAN !!
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of PCDA6_HUMAN

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Related Literatures of Post-Translational Modification

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