TORSO_DROME - dbPTM
TORSO_DROME - PTM Information in dbPTM
Basic Information of Protein
UniProt ID TORSO_DROME
UniProt AC P18475
Protein Name Tyrosine-protein kinase receptor torso
Gene Name tor
Organism Drosophila melanogaster (Fruit fly).
Sequence Length 923
Subcellular Localization Membrane
Single-pass type I membrane protein.
Protein Description Probable receptor tyrosine kinase which is required for determination of anterior and posterior terminal structures in the embryo. [PubMed: 2927509]
Protein Sequence MLIFYAKYAFIFWFFVGSNQGEMLLMDKISHDKTLLNVTACTQNCLEKGQMDFRSCLKDCRINGTFPGALRKVQENYQMNMICRTESEIVFQIDWVQHSRGTEPAPNATYIIRVDAVKDDNKETALYLSDDNFLILPGLESNSTHNITALAMHGDGSYSLIAKDQTFATLIRGYQPSKMGAVNLLRFVPQPDDLHHIAAEIEWKPSAESNCYFDMVSYSTNSVNMDEPLEVQFRDRKKLYRHTVDNLEFDKQYHVGVRTVNIMNRLESDLQWLPIAVPSCLDWYPYNYTLCPPHKPENLTVTQKQYLPNILALNITWARPRYLPDNYTLHIFDLFKGGTELNYTLDQNRSHFYVPKITVLGSHFEVHLVAQSAGGKNVSGLTLDKVHRGVLLSEGNMVKLVLFIIVPICCILMLCSLTFCRRNRSEVQALQMDAKDAKASEFHLSLMDSSGLLVTLSANESLEVMDELEVEPHSVLLQDVLGEGAFGLVRRGVYKKRQVAVKLLKDEPNDEDVYAFKCEIQMLKAVGKHPNIVGIVGYSTRFSNQMMLLIEYCSLGSLQNFLREEWKFRQEQNAIGLKKNLEQNVDNRRFNRLPRNSIHDRIEDINNSMLSTVEEESESDQTHSSRCETYTLTRITNAADNKGYGLEDIENIGGSYIPKTAEAPKDRPKRKLKPQPKKDSKQDFKSDNKKRIFENKEYFDCLDSSDTKPRIPLKYADLLDIAQQVAVGMEFLAQNKVVHRDLAARNVLISVDRSIKIADFGLSRDVYHENVYRKSGGSGKLPIKWLALESLTHQVYTSQSDVWSFGVLLYEITTLGGMPYPSVSPSDLLQLLRQGHRMKRPEGCTQEMFSLMESCWSSVPSHRPTFSALKHRLGGMILATNDVPERLKQLQAATESKLKSCDGLNSKVEQVPCEEELYLEPLN
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
37N-linked_GlycosylationSHDKTLLNVTACTQN
CCCCCCCHHHHHHHH		32.00-
63N-linked_GlycosylationCLKDCRINGTFPGAL
HHHHCCCCCCCCCHH		24.89-
107N-linked_GlycosylationRGTEPAPNATYIIRV
CCCCCCCCCEEEEEE		47.20-
142N-linked_GlycosylationILPGLESNSTHNITA
EECCCCCCCCCCEEE		41.36-
146N-linked_GlycosylationLESNSTHNITALAMH
CCCCCCCCEEEEEEC		33.13-
287N-linked_GlycosylationCLDWYPYNYTLCPPH
HCCCCCCCCEECCCC		20.86-
298N-linked_GlycosylationCPPHKPENLTVTQKQ
CCCCCCCCCEECCHH		49.92-
314N-linked_GlycosylationLPNILALNITWARPR
HCCEEEEEEEECCCC		24.84-
326N-linked_GlycosylationRPRYLPDNYTLHIFD
CCCCCCCCEEEEEEE		29.74-
342N-linked_GlycosylationFKGGTELNYTLDQNR
CCCCEEEEEEECCCC		22.85-
348N-linked_GlycosylationLNYTLDQNRSHFYVP
EEEEECCCCCCEEEC		47.27-
377N-linked_GlycosylationAQSAGGKNVSGLTLD
EECCCCCCCCCCCCC		36.14-
608PhosphorylationRIEDINNSMLSTVEE
HHHHHHHHHHHCCCH		19.3322817900
630PhosphorylationHSSRCETYTLTRITN
CHHHCEEEEEEEEEC		4.219885560
644PhosphorylationNAADNKGYGLEDIEN
CCCCCCCCCCHHHHH		21.839892666
698PhosphorylationRIFENKEYFDCLDSS
HHCCCHHHHHCCCCC		13.319892666
767PhosphorylationFGLSRDVYHENVYRK
CCCCCCCEECCCCHH		14.019892666
772PhosphorylationDVYHENVYRKSGGSG
CCEECCCCHHCCCCC		24.739892666
918PhosphorylationVPCEEELYLEPLN--
CCCCCCCCEEECC--		16.589885560
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources
630YPhosphorylationKinaseTORQ9VK45
PhosphoELM
630YPhosphorylationKinaseMTOR-GPS
918YPhosphorylationKinaseTORQ9VK45
PhosphoELM
918YPhosphorylationKinaseMTOR-GPS
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of TORSO_DROME !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of TORSO_DROME !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
KRAF1_DROMEphlgenetic
20008569
KRAF1_DROMEphlgenetic
12750336
GIANT_DROMEgtgenetic
1905816
DSOR1_DROMEDsor1genetic
9136016
DSOR1_DROMEDsor1genetic
12750336
DECA_DROMEdppgenetic
1905816
DECA_DROMEdppgenetic
12750336
AFF4_DROMElilligenetic
12750336
MAD_DROMEMadgenetic
12750336
BOWEL_DROMEbowlgenetic
8384582
BOWEL_DROMEbowlgenetic
12750336
BTKL_DROMEBtk29Agenetic
11014822
SOS_DROMESosgenetic
8384582
SOS_DROMESosgenetic
12750336
1433Z_DROME14-3-3zetagenetic
9374412
1433Z_DROME14-3-3zetagenetic
12750336
DRK_DROMEdrkgenetic
8384582
DRK_DROMEdrkgenetic
12750336
DOS_DROMEdosgenetic
10882065
HSP83_DROMEHsp83genetic
12750336
SPY_DROMEstygenetic
10089881
BYN_DROMEbyngenetic
12750336
BCD_DROMEbcdgenetic
10952897
RAS1_DROMERas85Dgenetic
8384582
RAS1_DROMERas85Dgenetic
12750336
RAS1_DROMERas85Dgenetic
19965758
1433E_DROME14-3-3epsilongenetic
12750336
STAT_DROMEStat92Egenetic
12183376
STAT_DROMEStat92Egenetic
12750336
TSL_DROMEtslgenetic
23959885
TLL_DROMEtllgenetic
12750336
CSW_DROMEcswgenetic
12750336
ERKA_DROMErlgenetic
8124723
ERKA_DROMErlgenetic
12750336
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of TORSO_DROME

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Phosphoproteome analysis of Drosophila melanogaster embryos.";
Zhai B., Villen J., Beausoleil S.A., Mintseris J., Gygi S.P.;
J. Proteome Res. 7:1675-1682(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-608, AND MASSSPECTROMETRY.

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