TSL_DROME - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: TSL_DROME
• UniProt AC: P40689
• Protein Name: Torso-like protein
• Gene Name: tsl
• Organism: Drosophila melanogaster (Fruit fly).
• Sequence Length: 353
• Subcellular Localization: Secreted . Is a component of the vitelline membrane (VM, the inner layer of the eggshell).
• Protein Description: Probable ligand that binds to the torso receptor. Implicated in a receptor tyrosine kinase signaling pathway that specifies terminal cell fate..
• Protein Sequence: MRSWPGLFWLLTLALLADGGRRESQLRIGKAINIFLRYGYLGISMRVIPLNDNSEPDRWVFKEPTKNIYRNLSGLAESHEDTTPGIFHGDFHMEFCENRRQLFQAYFRDFSIERMDKPWEAFTGGWFPDNAAKKLGINTSFIQGDYSYVLVRVVRFRETGRLNAEIPVHQPLEPDVRSRMDQLQIGNITSAVRFMEDVGTHYVNSYTTGNSLYQVFVYSRKNYSMIKERIKSKGLNGLSKLDLYNYFAPWFAAHLGQIRSASANATVERWARRKLQYEYYVVKYVTLLKLHGNSTLLRSLDSLLGNDAILQLDLKSLKPIFREEPEKESWYHEVLDNNVKLWELNMPQSHPTR

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
71	N-linked_Glycosylation	PTKNIYRNLSGLAES CCHHHHHHHHHHHHC	22.91	-
138	N-linked_Glycosylation	AAKKLGINTSFIQGD HHHHHCCCCHHCCCC	28.07	-
187	N-linked_Glycosylation	MDQLQIGNITSAVRF CHHHCCCCHHHHHHH	35.67	-
222	N-linked_Glycosylation	VFVYSRKNYSMIKER EEEEECCCHHHHHHH	32.76	-
264	N-linked_Glycosylation	QIRSASANATVERWA HHHHHHCCHHHHHHH	33.38	17893096
293	N-linked_Glycosylation	TLLKLHGNSTLLRSL EEEECCCCHHHHHHH	22.52	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of TSL_DROME !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of TSL_DROME !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of TSL_DROME !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
TRUNK_DROME	trk	genetic	9510028
TORSO_DROME	tor	genetic	23959885
TORSO_DROME	tor	genetic	9510028
BCD_DROME	bcd	genetic	10952897
STAT_DROME	Stat92E	genetic	16753285

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

N-linked Glycosylation

"Identification of N-glycosylated proteins from the central nervoussystem of Drosophila melanogaster.";
Koles K., Lim J.-M., Aoki K., Porterfield M., Tiemeyer M., Wells L.,Panin V.;
Glycobiology 17:1388-1403(2007).
Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-264, AND MASSSPECTROMETRY.
PubMed: 17893096