dbPTM

BOWEL_DROME - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	BOWEL_DROME
UniProt AC	Q9VQU9
Protein Name	Protein bowel
Gene Name	bowl {ECO:0000312\|FlyBase:FBgn0004893}
Organism	Drosophila melanogaster (Fruit fly).
Sequence Length	744
Subcellular Localization	Nucleus .
Protein Description	Putative transcription factor. Required for leg joint formation, acting downstream of Notch to pattern the leg tarsal segments. Functions in the terminal pathway during embryogenesis, acting downstream of tll in the posterior of the embryo. Acts in a hierarchy downstream of drm and lin during foregut and hindgut patterning and morphogenesis. Involved in cell rearrangement during elongation of the embryonic hindgut. Regulates expression of hindgut patterning genes to establish the small intestine region of the embryonic hindgut. Required in the foregut for spatially localized gene expression and morphogenesis of the proventriculus..
Protein Sequence	MPTESSSSEISGGGGGAIPMLRPSRMDQFMNSMAAAAAAVGGGGLPGAADRNGGSGGSDGGSQNGNGDSRNSSASRISAYETQLAYQQHLAGLHGPPPPPPPSHHREISAFVPVLPTGKVRPGSNSNYEIIAMMADKRKELALREAAAAAAMLGRGPGGPGGPGVPPPGVLYGPAGVPPPPYLTGPGPSPTGAGSFPFPPGAAAAALFPPGLGPGMHAGLDRRLLRAPGRASRPKKQFICKFCNRQFTKSYNLLIHERTHTDERPYSCDICGKAFRRQDHLRDHRYIHSKEKPFKCTECGKGFCQSRTLAVHKILHMEESPHKCPVCSRSFNQRSNLKTHLLTHTDHKPYECSSCGKVFRRNCDLRRHALTHAVGEVNSGDYVDVGEEDEARNLSGDEEDSLLEVDSPRQSPVHNLGESGGSGEKSESERMRLKRKAAIDHEESEEEFDDFDEEEELQDLPRVHDLPREEDDDFDPEDEEQAEVALVARFQASKAAATSQSSSSVGTKPERQGVTHCHHEGGETYTMRPHGEKHQEEPGNSGIASLPVPPSFVRYSVPPGAAGPPPAPPGAPPPTHQHPGHPHLLPPNGDPYLPILHVRRDLHHKSLNLSKAGVPPPPHTPPTIITQPESGKPPNQPLHSPHEAMPSFLGSIPMRKRILPAPTLDLMDPHHHPGLGQRTFVDSPSIYALNMSRHPPRQLLGKPPSTETSGATTEKGPPVAAPPIAPPPAPPRRTGFSIEDIMRR

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
395	Phosphorylation	EDEARNLSGDEEDSL HHHHHHCCCCCCCCC	47.98	22817900
407	Phosphorylation	DSLLEVDSPRQSPVH CCCEECCCCCCCCCC	27.45	22817900
411	Phosphorylation	EVDSPRQSPVHNLGE ECCCCCCCCCCCCCC	30.12	22817900

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of BOWEL_DROME !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of BOWEL_DROME !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of BOWEL_DROME !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
BCD_DROME	bcd	physical	14605208
LINES_DROME	lin	physical	14605208

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of BOWEL_DROME

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Phosphoproteome analysis of Drosophila melanogaster embryos."; Zhai B., Villen J., Beausoleil S.A., Mintseris J., Gygi S.P.; J. Proteome Res. 7:1675-1682(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-395 AND SER-407, ANDMASS SPECTROMETRY.	18327897 [Abstract]