SNX21_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: SNX21_HUMAN
• UniProt AC: Q969T3
• Protein Name: Sorting nexin-21
• Gene Name: SNX21
• Organism: Homo sapiens (Human).
• Sequence Length: 373
• Subcellular Localization: Cytoplasmic vesicle membrane ; Peripheral membrane protein; Cytoplasmic side. Early endosome membrane ; Peripheral membrane protein ; Cytoplasmic side .
• Protein Description: Binds to membranes enriched in phosphatidylinositol 3-phosphate (PtdIns(P3)) and phosphatidylinositol 4,5-bisphosphate. May be involved in several stages of intracellular trafficking..
• Protein Sequence: MHRGTQEGAMASRLLHRLRHALAGDGPGEAAASPEAEQFPESSELEDDDAEGLSSRLSGTLSFTSAEDDEDDEDEDDEEAGPDQLPLGDGTSGEDAERSPPPDGQWGSQLLARQLQDFWKKSRNTLAPQRLLFEVTSANVVKDPPSKYVLYTLAVIGPGPPDCQPAQISRRYSDFERLHRNLQRQFRGPMAAISFPRKRLRRNFTAETIARRSRAFEQFLGHLQAVPELRHAPDLQDFFVLPELRRAQSLTCTGLYREALALWANAWQLQAQLGTPSGPDRPLLTLAGLAVCHQELEDPGEARACCEKALQLLGDKSLHPLLAPFLEAHVRLSWRLGLDKRQSEARLQALQEAGLTPTPPPSLKELLIKEVLD

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
33	Phosphorylation	GPGEAAASPEAEQFP CCCHHCCCHHHHHCC	20.67	21712546
54	Phosphorylation	DDDAEGLSSRLSGTL CCCCHHHHHHHCCEE	25.03	22210691
55	Phosphorylation	DDAEGLSSRLSGTLS CCCHHHHHHHCCEEE	42.13	22210691
136	O-linked_Glycosylation	QRLLFEVTSANVVKD HHHHEEECCCCCCCC	18.22	28657654
137	Phosphorylation	RLLFEVTSANVVKDP HHHEEECCCCCCCCC	24.03	-
146 (in isoform 3)	Phosphorylation	-	41.84	-
173	Phosphorylation	AQISRRYSDFERLHR HHHHHHHHHHHHHHH	33.73	25850435
194	Phosphorylation	RGPMAAISFPRKRLR CCCCHHHHCCHHHHH	25.19	28857561
333	Phosphorylation	LEAHVRLSWRLGLDK HHHHHHHHHHCCCCH	10.29	24719451

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of SNX21_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of SNX21_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of SNX21_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
A4_HUMAN	APP	physical	21832049
HD_HUMAN	HTT	physical	28514442
FP100_HUMAN	C17orf70	physical	28514442
EIF2A_HUMAN	EIF2A	physical	28514442
TRI65_HUMAN	TRIM65	physical	28514442
PMS1_HUMAN	PMS1	physical	28514442
TBA4A_HUMAN	TUBA4A	physical	28514442
EME1_HUMAN	EME1	physical	28514442
VP13B_HUMAN	VPS13B	physical	28514442
S4A7_HUMAN	SLC4A7	physical	28514442
DDX11_HUMAN	DDX11	physical	28514442
TBA1A_HUMAN	TUBA1A	physical	28514442
PTHB1_HUMAN	BBS9	physical	28514442
RPA34_HUMAN	CD3EAP	physical	28514442
HEAT6_HUMAN	HEATR6	physical	28514442
DPOA2_HUMAN	POLA2	physical	28514442
DPOE2_HUMAN	POLE2	physical	28514442
DCAM_HUMAN	AMD1	physical	28514442
CBWD1_HUMAN	CBWD1	physical	28514442
MADD_HUMAN	MADD	physical	28514442
F91A1_HUMAN	FAM91A1	physical	28514442
TBB3_HUMAN	TUBB3	physical	28514442
OCRL_HUMAN	OCRL	physical	28514442
ATG2B_HUMAN	ATG2B	physical	28514442
APC5_HUMAN	ANAPC5	physical	28514442
MELK_HUMAN	MELK	physical	28514442
MCM8_HUMAN	MCM8	physical	28514442
RPA1_HUMAN	POLR1A	physical	28514442
MKS1_HUMAN	MKS1	physical	28514442

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.