RGS3_HUMAN - dbPTM
RGS3_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID RGS3_HUMAN
UniProt AC P49796
Protein Name Regulator of G-protein signaling 3
Gene Name RGS3
Organism Homo sapiens (Human).
Sequence Length 1198
Subcellular Localization Cytoplasm . Nucleus . Cell membrane
Peripheral membrane protein . Long isoforms are cytoplasmic and associated with the plasma membrane (PubMed:9858594). Short isoforms are nuclear (PubMed:10749886).
Protein Description Down-regulates signaling from heterotrimeric G-proteins by increasing the GTPase activity of the alpha subunits, thereby driving them into their inactive GDP-bound form. Down-regulates G-protein-mediated release of inositol phosphates and activation of MAP kinases..
Protein Sequence MPVIPALWEVEMGRSQGQEIETILANRSHSDSTPLPNFLSGSHRPECCTCRLLTASGAQDSLPFGRRLYSGPWRSCEEVCHVSVLSVLSTSCGLSLSLPIFPGWMEWLSPDIALPRRDEWTQTSPARKRITHAKVQGAGQLRLSIDAQDRVLLLHIIEGKGLISKQPGTCDPYVKISLIPEDSRLRHQKTQTVPDCRDPAFHEHFFFPVQEEDDQKRLLVTVWNRASQSRQSGLIGCMSFGVKSLLTPDKEISGWYYLLGEHLGRTKHLKVARRRLRPLRDPLLRMPGGGDTENGKKLKITIPRGKDGFGFTICCDSPVRVQAVDSGGPAERAGLQQLDTVLQLNERPVEHWKCVELAHEIRSCPSEIILLVWRMVPQVKPGPDGGVLRRASCKSTHDLQSPPNKREKNCTHGVQARPEQRHSCHLVCDSSDGLLLGGWERYTEVAKRGGQHTLPALSRATAPTDPNYIILAPLNPGSQLLRPVYQEDTIPEESGSPSKGKSYTGLGKKSRLMKTVQTMKGHGNYQNCPVVRPHATHSSYGTYVTLAPKVLVFPVFVQPLDLCNPARTLLLSEELLLYEGRNKAAEVTLFAYSDLLLFTKEDEPGRCDVLRNPLYLQSVKLQEGSSEDLKFCVLYLAEKAECLFTLEAHSQEQKKRVCWCLSENIAKQQQLAASPPDSKMFETEADEKREMALEEGKGPGAEDSPPSKEPSPGQELPPGQDLPPNKDSPSGQEPAPSQEPLSSKDSATSEGSPPGPDAPPSKDVPPCQEPPPAQDLSPCQDLPAGQEPLPHQDPLLTKDLPAIQESPTRDLPPCQDLPPSQVSLPAKALTEDTMSSGDLLAATGDPPAAPRPAFVIPEVRLDSTYSQKAGAEQGCSGDEEDAEEAEEVEEGEEGEEDEDEDTSDDNYGERSEAKRSSMIETGQGAEGGLSLRVQNSLRRRTHSEGSLLQEPRGPCFASDTTLHCSDGEGAASTWGMPSPSTLKKELGRNGGSMHHLSLFFTGHRKMSGADTVGDDDEASRKRKSKNLAKDMKNKLGIFRRRNESPGAPPAGKADKMMKSFKPTSEEALKWGESLEKLLVHKYGLAVFQAFLRTEFSEENLEFWLACEDFKKVKSQSKMASKAKKIFAEYIAIQACKEVNLDSYTREHTKDNLQSVTRGCFDLAQKRIFGLMEKDSYPRFLRSDLYLDLINQKKMSPPL
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
54PhosphorylationCCTCRLLTASGAQDS
CCCCEEEECCCCCCC		24.3022210691
69PhosphorylationLPFGRRLYSGPWRSC
CCCCCCCCCCCCCCH		15.1222210691
144PhosphorylationGAGQLRLSIDAQDRV
CCCEEEEEEECCCCE		16.4025072903
164PhosphorylationIEGKGLISKQPGTCD
EECCCCCCCCCCCCC		30.2224719451
169PhosphorylationLISKQPGTCDPYVKI
CCCCCCCCCCCCEEE		22.0328152594
173PhosphorylationQPGTCDPYVKISLIP
CCCCCCCCEEEEECC		10.9228152594
177PhosphorylationCDPYVKISLIPEDSR
CCCCEEEEECCCCCC		17.9628787133
232PhosphorylationRASQSRQSGLIGCMS
HHHHHHHCCCCCHHH		34.16-
264PhosphorylationYLLGEHLGRTKHLKV
HHHHHHCCCCHHHHH		36.8019651622
301PhosphorylationNGKKLKITIPRGKDG
CCCEEEEEECCCCCC		24.2824719451
308 (in isoform 8)Phosphorylation-28.2325690035
313 (in isoform 8)Phosphorylation-1.7425690035
317PhosphorylationGFTICCDSPVRVQAV
CEEEEECCCEEEEEE		16.0428674419
339 (in isoform 4)Ubiquitination-30.3621906983
339UbiquitinationRAGLQQLDTVLQLNE
HHHHHHHHHHHHCCC		30.36-
392PhosphorylationGGVLRRASCKSTHDL
CCEEEECCCCCCCCC		21.9224501219
395PhosphorylationLRRASCKSTHDLQSP
EEECCCCCCCCCCCC		34.9923403867
396PhosphorylationRRASCKSTHDLQSPP
EECCCCCCCCCCCCC		12.6123403867
401PhosphorylationKSTHDLQSPPNKREK
CCCCCCCCCCCCCCC		50.0125849741
423PhosphorylationARPEQRHSCHLVCDS
CCHHHCCCCEEEEEC		12.8628857561
430PhosphorylationSCHLVCDSSDGLLLG
CCEEEEECCCCEEEE		25.7928842319
431PhosphorylationCHLVCDSSDGLLLGG
CEEEEECCCCEEEEC		23.5828842319
442PhosphorylationLLGGWERYTEVAKRG
EEECHHHHHHHHHHC		8.85-
448MethylationRYTEVAKRGGQHTLP
HHHHHHHHCCCCCHH		44.7424129315
453PhosphorylationAKRGGQHTLPALSRA
HHHCCCCCHHCHHCC		26.9223403867
468PhosphorylationTAPTDPNYIILAPLN
CCCCCCCEEEEEECC		8.5027642862
478PhosphorylationLAPLNPGSQLLRPVY
EEECCCCHHCCCCCC		20.9327174698
485PhosphorylationSQLLRPVYQEDTIPE
HHCCCCCCCCCCCCC		14.6327174698
489PhosphorylationRPVYQEDTIPEESGS
CCCCCCCCCCCCCCC		37.3626657352
494PhosphorylationEDTIPEESGSPSKGK
CCCCCCCCCCCCCCC		42.8027174698
496PhosphorylationTIPEESGSPSKGKSY
CCCCCCCCCCCCCCC		34.9729116813
498PhosphorylationPEESGSPSKGKSYTG
CCCCCCCCCCCCCCC		56.5927174698
501UbiquitinationSGSPSKGKSYTGLGK
CCCCCCCCCCCCCCH		43.98-
502PhosphorylationGSPSKGKSYTGLGKK
CCCCCCCCCCCCCHH		36.2726657352
503PhosphorylationSPSKGKSYTGLGKKS
CCCCCCCCCCCCHHH		14.33-
508 (in isoform 5)Ubiquitination-53.2521906983
516 (in isoform 6)Ubiquitination-3.5821906983
525PhosphorylationTMKGHGNYQNCPVVR
HHCCCCCCCCCCEEC		12.99-
536PhosphorylationPVVRPHATHSSYGTY
CEECCCCCCCCCCCE		21.18-
545PhosphorylationSSYGTYVTLAPKVLV
CCCCCEEEECCEEEE		13.54-
620 (in isoform 3)Ubiquitination-50.1021906983
620UbiquitinationPLYLQSVKLQEGSSE
CEEEEEEECCCCCCH		50.102190698
662PhosphorylationKRVCWCLSENIAKQQ
HHHHHHHCHHHHHHH		26.0119651622
674PhosphorylationKQQQLAASPPDSKMF
HHHHHHCCCCCHHHC		31.2121815630
678PhosphorylationLAASPPDSKMFETEA
HHCCCCCHHHCCCHH		31.6223403867
683PhosphorylationPDSKMFETEADEKRE
CCHHHCCCHHHHHHH		25.8029978859
704PhosphorylationKGPGAEDSPPSKEPS
CCCCCCCCCCCCCCC		30.1621815630
728PhosphorylationDLPPNKDSPSGQEPA
CCCCCCCCCCCCCCC		23.6828674419
730PhosphorylationPPNKDSPSGQEPAPS
CCCCCCCCCCCCCCC		57.9921815630
746PhosphorylationEPLSSKDSATSEGSP
CCCCCCCCCCCCCCC		36.8628102081
748PhosphorylationLSSKDSATSEGSPPG
CCCCCCCCCCCCCCC		31.1228102081
749PhosphorylationSSKDSATSEGSPPGP
CCCCCCCCCCCCCCC		39.4127732954
752PhosphorylationDSATSEGSPPGPDAP
CCCCCCCCCCCCCCC		24.7021815630
777PhosphorylationPPPAQDLSPCQDLPA
CCCCCCCCCCCCCCC		31.7428188228
806PhosphorylationDLPAIQESPTRDLPP
CCCCCCCCCCCCCCC		18.3929255136
808PhosphorylationPAIQESPTRDLPPCQ
CCCCCCCCCCCCCCC		46.2029255136
820PhosphorylationPCQDLPPSQVSLPAK
CCCCCCHHHCCCCHH		41.0726552605
823PhosphorylationDLPPSQVSLPAKALT
CCCHHHCCCCHHHCC		22.4626552605
835PhosphorylationALTEDTMSSGDLLAA
HCCCCCCCCCCCHHH		33.0127251275
836PhosphorylationLTEDTMSSGDLLAAT
CCCCCCCCCCCHHHC		26.0427251275
865PhosphorylationEVRLDSTYSQKAGAE
EEECCCCCHHCCCCC		17.0423532336
866PhosphorylationVRLDSTYSQKAGAEQ
EECCCCCHHCCCCCC		25.8723532336
916PhosphorylationERSEAKRSSMIETGQ
HHHHHHHHHCCCCCC		24.4523927012
917PhosphorylationRSEAKRSSMIETGQG
HHHHHHHHCCCCCCC		28.0123927012
921PhosphorylationKRSSMIETGQGAEGG
HHHHCCCCCCCCCCC		24.7123403867
930PhosphorylationQGAEGGLSLRVQNSL
CCCCCCEEHHHHCCH		19.8723403867
936PhosphorylationLSLRVQNSLRRRTHS
EEHHHHCCHHCCCCC		13.2328102081
941PhosphorylationQNSLRRRTHSEGSLL
HCCHHCCCCCCCCCC		28.1323927012
943PhosphorylationSLRRRTHSEGSLLQE
CHHCCCCCCCCCCCC		42.9423927012
946PhosphorylationRRTHSEGSLLQEPRG
CCCCCCCCCCCCCCC		23.1223927012
958PhosphorylationPRGPCFASDTTLHCS
CCCCCCCCCCEEECC		18.4226074081
960PhosphorylationGPCFASDTTLHCSDG
CCCCCCCCEEECCCC		28.8526074081
961PhosphorylationPCFASDTTLHCSDGE
CCCCCCCEEECCCCC		21.3526074081
965PhosphorylationSDTTLHCSDGEGAAS
CCCEEECCCCCCCHH		37.5926074081
972PhosphorylationSDGEGAASTWGMPSP
CCCCCCHHHCCCCCH		24.9426074081
973PhosphorylationDGEGAASTWGMPSPS
CCCCCHHHCCCCCHH		22.7027080861
978PhosphorylationASTWGMPSPSTLKKE
HHHCCCCCHHHHHHH		23.6926074081
980PhosphorylationTWGMPSPSTLKKELG
HCCCCCHHHHHHHHC		51.1927080861
981PhosphorylationWGMPSPSTLKKELGR
CCCCCHHHHHHHHCC		46.0827080861
992PhosphorylationELGRNGGSMHHLSLF
HHCCCCCCCCEEEEE		19.1529802988
1007PhosphorylationFTGHRKMSGADTVGD
ECCCCCCCCCCCCCC		33.5923927012
1011PhosphorylationRKMSGADTVGDDDEA
CCCCCCCCCCCCHHH		26.3426657352
1023AcetylationDEASRKRKSKNLAKD
HHHHHHHHHHHHHHH		69.677834019
1029AcetylationRKSKNLAKDMKNKLG
HHHHHHHHHHHHHHH		62.617834029
1032AcetylationKNLAKDMKNKLGIFR
HHHHHHHHHHHHHHH		62.157834039
1044PhosphorylationIFRRRNESPGAPPAG
HHHHCCCCCCCCCCC		31.9829255136
1064PhosphorylationMKSFKPTSEEALKWG
HHHCCCCHHHHHHHH		41.80-
1114PhosphorylationEDFKKVKSQSKMASK
CHHHHHHHHHHHHHH		42.5528258704
1116PhosphorylationFKKVKSQSKMASKAK
HHHHHHHHHHHHHHH		31.3328258704
1117AcetylationKKVKSQSKMASKAKK
HHHHHHHHHHHHHHH		30.747677659
1120PhosphorylationKSQSKMASKAKKIFA
HHHHHHHHHHHHHHH		29.6417929957
1121AcetylationSQSKMASKAKKIFAE
HHHHHHHHHHHHHHH		55.477677669
1124AcetylationKMASKAKKIFAEYIA
HHHHHHHHHHHHHHH		48.1730591907
1129PhosphorylationAKKIFAEYIAIQACK
HHHHHHHHHHHHHHH		7.6928851738
1136AcetylationYIAIQACKEVNLDSY
HHHHHHHHHCCCHHH		68.6530591913
1173MalonylationRIFGLMEKDSYPRFL
HHHHHHCCCCCCHHH		37.7032601280
1175PhosphorylationFGLMEKDSYPRFLRS
HHHHCCCCCCHHHCC		48.3726074081
1176PhosphorylationGLMEKDSYPRFLRSD
HHHCCCCCCHHHCCH		14.4626074081
1195PhosphorylationLINQKKMSPPL----
HHHHCCCCCCC----		32.0423403867
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of RGS3_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of RGS3_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of RGS3_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
GNAI3_HUMANGNAI3physical
9858594
GNA11_HUMANGNA11physical
9858594
1433B_HUMANYWHABphysical
10862767
1433T_MOUSEYwhaqphysical
11985497
1433E_MOUSEYwhaephysical
11985497
A4_HUMANAPPphysical
21832049
GNAI2_HUMANGNAI2physical
12193720
GNA11_HUMANGNA11physical
12193720
GORS2_HUMANGORASP2physical
25416956
CACP_HUMANCRATphysical
28514442
UACA_HUMANUACAphysical
28514442
SKAP2_HUMANSKAP2physical
28514442
CEP72_HUMANCEP72physical
28514442
RBAK_HUMANRBAKphysical
28514442
EFNB2_HUMANEFNB2physical
28514442
ATG9A_HUMANATG9Aphysical
28514442
ZKSC8_HUMANZKSCAN8physical
28514442
ZNF24_HUMANZNF24physical
28514442
REL_HUMANRELphysical
28514442
KCTD2_HUMANKCTD2physical
28514442
Z324B_HUMANZNF324Bphysical
28514442
COR2A_HUMANCORO2Aphysical
28514442
ISCA1_HUMANISCA1physical
28514442
EFNB1_HUMANEFNB1physical
28514442
CEP44_HUMANCEP44physical
28514442
EFNB3_HUMANEFNB3physical
28514442
ZN646_HUMANZNF646physical
28514442
ZN446_HUMANZNF446physical
28514442
CKAP4_HUMANCKAP4physical
28514442
KLH24_HUMANKLHL24physical
28514442
ZSC30_HUMANZSCAN30physical
28514442
SEP10_HUMANSEPT10physical
28514442
ZN397_HUMANZNF397physical
28514442
SEPT2_HUMANSEPT2physical
28514442
PDLI7_HUMANPDLIM7physical
28514442
ZN460_HUMANZNF460physical
28514442
KLH23_HUMANKLHL23physical
28514442
KCD17_HUMANKCTD17physical
28514442
K0232_HUMANKIAA0232physical
28514442
ISCA2_HUMANISCA2physical
28514442
SEPT8_HUMANSEPT8physical
28514442
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of RGS3_HUMAN

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Quantitative phosphoproteomic analysis of T cell receptor signalingreveals system-wide modulation of protein-protein interactions.";
Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,Rodionov V., Han D.K.;
Sci. Signal. 2:RA46-RA46(2009).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-943 AND SER-946, ANDMASS SPECTROMETRY.

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