EFMT3_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: EFMT3_HUMAN
• UniProt AC: Q96AZ1
• Protein Name: EEF1A lysine methyltransferase 3 {ECO:0000312|HGNC:HGNC:24936}
• Gene Name: EEF1AKMT3 {ECO:0000312|HGNC:HGNC:24936}
• Organism: Homo sapiens (Human).
• Sequence Length: 226
• Subcellular Localization: Cytoplasm . Cytoplasm, cytoskeleton, microtubule organizing center, centrosome .
• Protein Description: Protein-lysine methyltransferase that selectively methylates EEF1A1 and EEF1A2 at 'Lys-165' in an aminoacyl-tRNA and GTP-dependent manner. EEF1A1 methylation by EEF1AKMT3 is dynamic as well as inducible by stress conditions, such as ER-stress, and plays a regulatory role on mRNA translation..
• Protein Sequence: MADPGPDPESESESVFPREVGLFADSYSEKSQFCFCGHVLTITQNFGSRLGVAARVWDAALSLCNYFESQNVDFRGKKVIELGAGTGIVGILAALQGGDVTITDLPLALEQIQGNVQANVPAGGQAQVRALSWGIDHHVFPANYDLVLGADIVYLEPTFPLLLGTLQHLCRPHGTIYLASKMRKEHGTESFFQHLLPQHFQLELAQRDEDENVNIYRARHREPRPA

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
10	Phosphorylation	DPGPDPESESESVFP CCCCCCCCCCCCCCC		25627689
12	Phosphorylation	GPDPESESESVFPRE CCCCCCCCCCCCCHH		25627689
14	Phosphorylation	DPESESESVFPREVG CCCCCCCCCCCHHHC		29255136
177	Phosphorylation	CRPHGTIYLASKMRK HCCCCCEEEEEHHHH		24719451

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of EFMT3_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of EFMT3_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of EFMT3_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
BAG2_HUMAN	BAG2	physical	23349634
BAG6_HUMAN	BAG6	physical	23349634
TCPB_HUMAN	CCT2	physical	23349634
TCPG_HUMAN	CCT3	physical	23349634
TCPD_HUMAN	CCT4	physical	23349634
TCPE_HUMAN	CCT5	physical	23349634
TCPZ_HUMAN	CCT6A	physical	23349634
TCPW_HUMAN	CCT6B	physical	23349634
TCPH_HUMAN	CCT7	physical	23349634
TCPQ_HUMAN	CCT8	physical	23349634
CATB_HUMAN	CTSB	physical	23349634
DNJA1_HUMAN	DNAJA1	physical	23349634
DNJA2_HUMAN	DNAJA2	physical	23349634
HS90A_HUMAN	HSP90AA1	physical	23349634
HS90B_HUMAN	HSP90AB1	physical	23349634
HS71L_HUMAN	HSPA1L	physical	23349634
HSP72_HUMAN	HSPA2	physical	23349634
GRP78_HUMAN	HSPA5	physical	23349634
HSP7C_HUMAN	HSPA8	physical	23349634
CH60_HUMAN	HSPD1	physical	23349634
HUWE1_HUMAN	HUWE1	physical	23349634
IGBP1_HUMAN	IGBP1	physical	23349634
CCAR2_HUMAN	CCAR2	physical	23349634
LAMP2_HUMAN	LAMP2	physical	23349634
LDHA_HUMAN	LDHA	physical	23349634
LDHB_HUMAN	LDHB	physical	23349634
MDHM_HUMAN	MDH2	physical	23349634
NTPCR_HUMAN	NTPCR	physical	23349634
PDCD5_HUMAN	PDCD5	physical	23349634
PFD1_HUMAN	PFDN1	physical	23349634
PFD2_HUMAN	PFDN2	physical	23349634
PFD4_HUMAN	PFDN4	physical	23349634
PFD5_HUMAN	PFDN5	physical	23349634
PFD6_HUMAN	PFDN6	physical	23349634
PPP6_HUMAN	PPP6C	physical	23349634
RN126_HUMAN	RNF126	physical	23349634
RUVB1_HUMAN	RUVBL1	physical	23349634
RUVB2_HUMAN	RUVBL2	physical	23349634
SAR1A_HUMAN	SAR1A	physical	23349634
SMC1A_HUMAN	SMC1A	physical	23349634
SMC3_HUMAN	SMC3	physical	23349634
STIP1_HUMAN	STIP1	physical	23349634
TCPA_HUMAN	TCP1	physical	23349634
TIPRL_HUMAN	TIPRL	physical	23349634
TBB2A_HUMAN	TUBB2A	physical	23349634
TBB3_HUMAN	TUBB3	physical	23349634
TBB4A_HUMAN	TUBB4A	physical	23349634
TBB6_HUMAN	TUBB6	physical	23349634
TBB8_HUMAN	TUBB8	physical	23349634
UBA1_HUMAN	UBA1	physical	23349634
UBB_HUMAN	UBB	physical	23349634
UBC_HUMAN	UBC	physical	23349634
UBL4A_HUMAN	UBL4A	physical	23349634
PFD3_HUMAN	VBP1	physical	23349634

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.