BACH1_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: BACH1_MOUSE
• UniProt AC: P97302
• Protein Name: Transcription regulator protein BACH1
• Gene Name: Bach1
• Organism: Mus musculus (Mouse).
• Sequence Length: 739
• Subcellular Localization: Nucleus .
• Protein Description: Transcriptional regulator that acts as repressor or activator. Binds, in vitro, to NF-E2 binding sites. Play important roles in coordinating transcription activation and repression by MAFK..
• Protein Sequence: MSVSESAVFAYESSVHSTNVLLSLNDQRKKDVLCDVTVLVEGQRFRAHRSVLAACSSYFHSRIVGQTDAELTVTLPEEVTVKGFEPLIQFAYTAKLILSKDNVDEVCRCVEFLSVHNIEESCFQFLKFKFLDSTSEQQECARKKCFSSHCQKADFKFSFSEQKDLEIDEADEFLEKKRVQTPQCDSRRCQGSVKASPPLQDSVSQACQSLCTDKDGALALPSLCPKYRKFQKAFGTDKIRTLESGVRDVHTASVQPNETSELECFGGAQGCADLHVILKCEGMKAAMESEDTEGQDPSPQCPAEQPQGTPLPQDSAGPHGLYSLSALHTYEQSGDVAFAGVQSKTVKTEKPLSRPDAQDEKPSENQDLYLKSSMGPKEDSSSLASEDRSSVEREVAEHLAKGFWSDICSTDSPCQMQLSPTVAKDGPEQGYSQRRSECPWLGIRISESPEPGQRTFTTLSSVNCPFISTLSSEGCSSNLEIGNYDYVSEPQQEPCPYACVISLGDDSETDTEGDSESCSAREQDCEVKLPFNAQRIISLSRNDFQSLLKMHKLTPEQLDCIHDIRRRSKNRIAAQRCRKRKLDCIQNLESEIEKLQSEKESLLKERDHILSTLGETKQNLTGLCQQVCKEAALSPEQIQILAKYSASDCPLSFLISEKGKSTPDGELAFTSVFSVSDVPPTAPPPCGRGSSAASQELVQESPPTTAAAPEQATLLEPCRQSAGISDFCQQMSDKCTTDE

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
158	Phosphorylation	QKADFKFSFSEQKDL HHCCEEEEHHHHHCC	28.58	27600695
196	Phosphorylation	CQGSVKASPPLQDSV CCCCCCCCCCCHHHH	22.72	25521595
222	Phosphorylation	DGALALPSLCPKYRK CCCCCCHHHCHHHHH	43.37	19854140
244	Phosphorylation	DKIRTLESGVRDVHT HHHHCHHHCCCEEEE	45.78	28059163
381	Phosphorylation	MGPKEDSSSLASEDR CCCCCCCCCCCCCCH	41.51	27600695
382	Phosphorylation	GPKEDSSSLASEDRS CCCCCCCCCCCCCHH	31.72	29899451
385	Phosphorylation	EDSSSLASEDRSSVE CCCCCCCCCCHHHHH	45.37	24719451
389	Phosphorylation	SLASEDRSSVEREVA CCCCCCHHHHHHHHH	51.57	25338131
390	Phosphorylation	LASEDRSSVEREVAE CCCCCHHHHHHHHHH	28.97	27600695
412	Phosphorylation	SDICSTDSPCQMQLS HHHCCCCCCCEEEEC	27.88	25159016
419	Phosphorylation	SPCQMQLSPTVAKDG CCCEEEECCCCCCCC	11.13	25159016
421	Phosphorylation	CQMQLSPTVAKDGPE CEEEECCCCCCCCCC	29.71	26643407
446	Phosphorylation	PWLGIRISESPEPGQ CCEEEECCCCCCCCC	23.36	25159016
448	Phosphorylation	LGIRISESPEPGQRT EEEECCCCCCCCCCC	27.98	26824392
486	Phosphorylation	LEIGNYDYVSEPQQE CEECCCCCCCCCCCC	8.77	22817900
597	Phosphorylation	SEIEKLQSEKESLLK HHHHHHHHHHHHHHH	62.16	20531401
601	Phosphorylation	KLQSEKESLLKERDH HHHHHHHHHHHHHHH	50.50	20531401
634	Phosphorylation	VCKEAALSPEQIQIL HHHHHCCCHHHHHHH	22.97	22942356
701	Phosphorylation	SQELVQESPPTTAAA HHHHHHCCCCCCCCC	21.06	30352176

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of BACH1_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of BACH1_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of BACH1_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
BACH1_MOUSE	Bach1	physical	20211142
XPO1_MOUSE	Xpo1	physical	15175654
MAFK_HUMAN	MAFK	physical	20360068
DYL1_HUMAN	DYNLL1	physical	20360068
MAFF_HUMAN	MAFF	physical	20360068
HMMR_HUMAN	HMMR	physical	20360068
ARF3_HUMAN	ARF3	physical	20360068
MAFG_HUMAN	MAFG	physical	20360068
ARF1_HUMAN	ARF1	physical	20360068
BACH1_HUMAN	BACH1	physical	20360068
FA83D_HUMAN	FAM83D	physical	20360068
HEXB_HUMAN	HEXB	physical	26496610
HMMR_HUMAN	HMMR	physical	26496610
MAFG_HUMAN	MAFG	physical	26496610
S12A2_HUMAN	SLC12A2	physical	26496610
TTC3_HUMAN	TTC3	physical	26496610
MAFK_HUMAN	MAFK	physical	26496610
PRDX4_HUMAN	PRDX4	physical	26496610
RM03_HUMAN	MRPL3	physical	26496610
KIF1B_HUMAN	KIF1B	physical	26496610
SYNEM_HUMAN	SYNM	physical	26496610
MAFF_HUMAN	MAFF	physical	26496610
CC174_HUMAN	CCDC174	physical	26496610
ELP3_HUMAN	ELP3	physical	26496610
FA83D_HUMAN	FAM83D	physical	26496610
MAGT1_HUMAN	MAGT1	physical	26496610
DPP9_HUMAN	DPP9	physical	26496610
ERIC3_HUMAN	ERICH3	physical	26496610
RETR3_HUMAN	FAM134C	physical	26496610

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.