dbPTM

UBP43_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	UBP43_HUMAN
UniProt AC	Q70EL4
Protein Name	Ubiquitin carboxyl-terminal hydrolase 43
Gene Name	USP43
Organism	Homo sapiens (Human).
Sequence Length	1123
Subcellular Localization
Protein Description	May recognize and hydrolyze the peptide bond at the C-terminal Gly of ubiquitin. Involved in the processing of poly-ubiquitin precursors as well as that of ubiquitinated proteins (By similarity)..
Protein Sequence	MDLGPGDAAGGGPLAPRPRRRRSLRRLFSRFLLALGSRSRPGDSPPRPQPGHCDGDGEGGFACAPGPVPAAPGSPGEERPPGPQPQLQLPAGDGARPPGAQGLKNHGNTCFMNAVVQCLSNTDLLAEFLALGRYRAAPGRAEVTEQLAALVRALWTREYTPQLSAEFKNAVSKYGSQFQGNSQHDALEFLLWLLDRVHEDLEGSSRGPVSEKLPPEATKTSENCLSPSAQLPLGQSFVQSHFQAQYRSSLTCPHCLKQSNTFDPFLCVSLPIPLRQTRFLSVTLVFPSKSQRFLRVGLAVPILSTVAALRKMVAEEGGVPADEVILVELYPSGFQRSFFDEEDLNTIAEGDNVYAFQVPPSPSQGTLSAHPLGLSASPRLAAREGQRFSLSLHSESKVLILFCNLVGSGQQASRFGPPFLIREDRAVSWAQLQQSILSKVRHLMKSEAPVQNLGSLFSIRVVGLSVACSYLSPKDSRPLCHWAVDRVLHLRRPGGPPHVKLAVEWDSSVKERLFGSLQEERAQDADSVWQQQQAHQQHSCTLDECFQFYTKEEQLAQDDAWKCPHCQVLQQGMVKLSLWTLPDILIIHLKRFCQVGERRNKLSTLVKFPLSGLNMAPHVAQRSTSPEAGLGPWPSWKQPDCLPTSYPLDFLYDLYAVCNHHGNLQGGHYTAYCRNSLDGQWYSYDDSTVEPLREDEVNTRGAYILFYQKRNSIPPWSASSSMRGSTSSSLSDHWLLRLGSHAGSTRGSLLSWSSAPCPSLPQVPDSPIFTNSLCNQEKGGLEPRRLVRGVKGRSISMKAPTTSRAKQGPFKTMPLRWSFGSKEKPPGASVELVEYLESRRRPRSTSQSIVSLLTGTAGEDEKSASPRSNVALPANSEDGGRAIERGPAGVPCPSAQPNHCLAPGNSDGPNTARKLKENAGQDIKLPRKFDLPLTVMPSVEHEKPARPEGQKAMNWKESFQMGSKSSPPSPYMGFSGNSKDSRRGTSELDRPLQGTLTLLRSVFRKKENRRNERAEVSPQVPPVSLVSGGLSPAMDGQAPGSPPALRIPEGLARGLGSRLERDVWSAPSSLRLPRKASRAPRGSALGMSQRTVPGEQASYGTFQRVKYHTLSLGRKKTLPESSF

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
3 (in isoform 2)	Phosphorylation	-	15.79	24043423
7 (in isoform 2)	Phosphorylation	-	36.06	24043423
8 (in isoform 2)	Phosphorylation	-	17.58	24043423
9 (in isoform 2)	Phosphorylation	-	23.15	24043423
13 (in isoform 2)	Phosphorylation	-	28.73	27732954
14 (in isoform 2)	Phosphorylation	-	13.34	27732954
15 (in isoform 2)	Phosphorylation	-	10.94	27732954
23	Phosphorylation	PRPRRRRSLRRLFSR CCHHHHHHHHHHHHH	25.15	26074081
24 (in isoform 2)	Phosphorylation	-	3.33	27732954
25 (in isoform 2)	Phosphorylation	-	34.21	27732954
29	Phosphorylation	RSLRRLFSRFLLALG HHHHHHHHHHHHHHC	27.07	26074081
37	Phosphorylation	RFLLALGSRSRPGDS HHHHHHCCCCCCCCC	28.12	26074081
39	Phosphorylation	LLALGSRSRPGDSPP HHHHCCCCCCCCCCC	44.52	26074081
283	Phosphorylation	QTRFLSVTLVFPSKS CCCEEEEEEECCCCC	17.52	-
304	Phosphorylation	GLAVPILSTVAALRK HCHHHHHHHHHHHHH	22.89	-
305	Phosphorylation	LAVPILSTVAALRKM CHHHHHHHHHHHHHH	15.66	-
391	Phosphorylation	EGQRFSLSLHSESKV CCCCEEEEEECCCCE	23.88	27251275
413	Phosphorylation	VGSGQQASRFGPPFL CCCCCHHHHHCCCEE	24.65	-
435	Phosphorylation	SWAQLQQSILSKVRH CHHHHHHHHHHHHHH	16.73	24719451
469	Phosphorylation	VGLSVACSYLSPKDS EEHHHHHHHCCCCCC	21.26	28348404
472	Phosphorylation	SVACSYLSPKDSRPL HHHHHHCCCCCCCCC	22.98	24719451
507	Phosphorylation	KLAVEWDSSVKERLF EEEEECCHHHHHHHH	37.80	-
508	Phosphorylation	LAVEWDSSVKERLFG EEEECCHHHHHHHHH	34.43	-
611	Phosphorylation	TLVKFPLSGLNMAPH HHCCCCCCCCCCHHH	41.28	-
623	Phosphorylation	APHVAQRSTSPEAGL HHHHHCCCCCCCCCC	22.58	28857561
624	Phosphorylation	PHVAQRSTSPEAGLG HHHHCCCCCCCCCCC	50.95	28857561
625	Phosphorylation	HVAQRSTSPEAGLGP HHHCCCCCCCCCCCC	23.22	24076635
635	Phosphorylation	AGLGPWPSWKQPDCL CCCCCCCCCCCCCCC	42.93	28102081
725	Phosphorylation	ASSSMRGSTSSSLSD CCHHCCCCCCCCCCC	18.10	27251275
726	Phosphorylation	SSSMRGSTSSSLSDH CHHCCCCCCCCCCCH	35.14	28348404
727	Phosphorylation	SSMRGSTSSSLSDHW HHCCCCCCCCCCCHH	21.45	28348404
728	Phosphorylation	SMRGSTSSSLSDHWL HCCCCCCCCCCCHHH	35.07	28348404
729	Phosphorylation	MRGSTSSSLSDHWLL CCCCCCCCCCCHHHH	31.49	28348404
731	Phosphorylation	GSTSSSLSDHWLLRL CCCCCCCCCHHHHHC	29.40	-
744	Phosphorylation	RLGSHAGSTRGSLLS HCCCCCCCCCCCHHC	18.73	24719451
746	Methylation	GSHAGSTRGSLLSWS CCCCCCCCCCHHCCC	34.11	-
746	Asymmetric dimethylarginine	GSHAGSTRGSLLSWS CCCCCCCCCCHHCCC	34.11	-
754	Phosphorylation	GSLLSWSSAPCPSLP CCHHCCCCCCCCCCC	29.94	28102081
759	Phosphorylation	WSSAPCPSLPQVPDS CCCCCCCCCCCCCCC	60.44	28102081
766	Phosphorylation	SLPQVPDSPIFTNSL CCCCCCCCCCCCCCC	17.52	27966365
770	Phosphorylation	VPDSPIFTNSLCNQE CCCCCCCCCCCCCCC	25.31	28102081
772	Phosphorylation	DSPIFTNSLCNQEKG CCCCCCCCCCCCCCC	31.10	28102081
794	Phosphorylation	VRGVKGRSISMKAPT HCCCCCCEEECCCCC	27.90	30183078
796	Phosphorylation	GVKGRSISMKAPTTS CCCCCEEECCCCCCC	18.57	27422710
812	Phosphorylation	AKQGPFKTMPLRWSF CCCCCCCCCCEEEEC	25.13	24719451
818	Phosphorylation	KTMPLRWSFGSKEKP CCCCEEEECCCCCCC	17.19	25159151
821	Phosphorylation	PLRWSFGSKEKPPGA CEEEECCCCCCCCCC	35.31	22617229
835	Phosphorylation	ASVELVEYLESRRRP CCHHHHHHHHHCCCC	14.32	28102081
838	Phosphorylation	ELVEYLESRRRPRST HHHHHHHHCCCCCCC	28.61	28102081
844	Phosphorylation	ESRRRPRSTSQSIVS HHCCCCCCCCHHHHH	34.78	30278072
845	Phosphorylation	SRRRPRSTSQSIVSL HCCCCCCCCHHHHHH	31.87	29116813
846	Phosphorylation	RRRPRSTSQSIVSLL CCCCCCCCHHHHHHH	24.15	30278072
847	Phosphorylation	RRPRSTSQSIVSLLT CCCCCCCHHHHHHHH	36.95	18669648
848	Phosphorylation	RPRSTSQSIVSLLTG CCCCCCHHHHHHHHC	25.40	28102081
849	Phosphorylation	PRSTSQSIVSLLTGT CCCCCHHHHHHHHCC	1.57	18669648
851	Phosphorylation	STSQSIVSLLTGTAG CCCHHHHHHHHCCCC	18.91	18669648
852	Phosphorylation	TSQSIVSLLTGTAGE CCHHHHHHHHCCCCC	3.25	18669648
854	Phosphorylation	QSIVSLLTGTAGEDE HHHHHHHHCCCCCCC	37.47	22210691
856	Phosphorylation	IVSLLTGTAGEDEKS HHHHHHCCCCCCCCC	26.67	23312004
863	Phosphorylation	TAGEDEKSASPRSNV CCCCCCCCCCCCCCC	31.75	24719451
865	Phosphorylation	GEDEKSASPRSNVAL CCCCCCCCCCCCCCC	28.12	23312004
876	Phosphorylation	NVALPANSEDGGRAI CCCCCCCCCCCCCCH	38.89	29083192
965	Phosphorylation	SFQMGSKSSPPSPYM HHCCCCCCCCCCCCC	50.18	28985074
966	Phosphorylation	FQMGSKSSPPSPYMG HCCCCCCCCCCCCCC	44.56	22617229
969	Phosphorylation	GSKSSPPSPYMGFSG CCCCCCCCCCCCCCC	31.85	22617229
971	Phosphorylation	KSSPPSPYMGFSGNS CCCCCCCCCCCCCCC	17.76	23090842
975	Phosphorylation	PSPYMGFSGNSKDSR CCCCCCCCCCCCCCC	31.19	28985074
978	Phosphorylation	YMGFSGNSKDSRRGT CCCCCCCCCCCCCCC	41.17	23090842
985	Phosphorylation	SKDSRRGTSELDRPL CCCCCCCCCCCCCHH	19.74	24719451
995	Phosphorylation	LDRPLQGTLTLLRSV CCCHHHHHHHHHHHH	12.01	23312004
997	Phosphorylation	RPLQGTLTLLRSVFR CHHHHHHHHHHHHHH	24.47	23312004
1024	Phosphorylation	SPQVPPVSLVSGGLS CCCCCCCEEEECCCC	28.91	28102081
1027	Phosphorylation	VPPVSLVSGGLSPAM CCCCEEEECCCCCCC	32.22	28102081
1031	Phosphorylation	SLVSGGLSPAMDGQA EEEECCCCCCCCCCC	17.56	28102081
1041	Phosphorylation	MDGQAPGSPPALRIP CCCCCCCCCCCHHCC	27.01	28102081
1042	Phosphorylation	DGQAPGSPPALRIPE CCCCCCCCCCHHCCH	24.89	18669648
1053	Methylation	RIPEGLARGLGSRLE HCCHHHHHCCCHHHH	46.01	115919633
1065	Phosphorylation	RLERDVWSAPSSLRL HHHHCCCCCCCCCCC	30.10	22617229
1068	Phosphorylation	RDVWSAPSSLRLPRK HCCCCCCCCCCCCCC	41.54	27050516
1069	Phosphorylation	DVWSAPSSLRLPRKA CCCCCCCCCCCCCCH	19.22	30183078
1071	Methylation	WSAPSSLRLPRKASR CCCCCCCCCCCCHHC	44.59	82797551
1081	Methylation	RKASRAPRGSALGMS CCHHCCCCCCCCCCC	51.19	115919637
1088	Phosphorylation	RGSALGMSQRTVPGE CCCCCCCCCCCCCCC	18.08	24719451
1098	Phosphorylation	TVPGEQASYGTFQRV CCCCCHHCCCCCHHH	24.64	25106551
1099	Phosphorylation	VPGEQASYGTFQRVK CCCCHHCCCCCHHHE	24.17	25106551
1101	Phosphorylation	GEQASYGTFQRVKYH CCHHCCCCCHHHEEE	14.36	28348404
1107	Phosphorylation	GTFQRVKYHTLSLGR CCCHHHEEEEECCCC	9.36	20873877
1109	Phosphorylation	FQRVKYHTLSLGRKK CHHHEEEEECCCCCC	18.23	20873877
1111	Phosphorylation	RVKYHTLSLGRKKTL HHEEEEECCCCCCCC	29.90	22617229
1111	O-linked_Glycosylation	RVKYHTLSLGRKKTL HHEEEEECCCCCCCC	29.90	30379171
1117	Phosphorylation	LSLGRKKTLPESSF- ECCCCCCCCCCCCC-	51.05	24719451

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of UBP43_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of UBP43_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of UBP43_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
PDCD2_HUMAN	PDCD2	physical	19615732
1433B_HUMAN	YWHAB	physical	19615732
1433E_HUMAN	YWHAE	physical	19615732
1433F_HUMAN	YWHAH	physical	19615732
PSME3_HUMAN	PSME3	physical	19615732
WDR3_HUMAN	WDR3	physical	19615732
VPS35_HUMAN	VPS35	physical	19615732
KT3K_HUMAN	FN3KRP	physical	19615732
MAGI3_HUMAN	MAGI3	physical	19615732
CSK2B_HUMAN	CSNK2B	physical	26496610
DDX11_HUMAN	DDX11	physical	26496610
TAU_HUMAN	MAPT	physical	26496610
NHS_HUMAN	NHS	physical	26496610
DPOD1_HUMAN	POLD1	physical	26496610
PSA2_HUMAN	PSMA2	physical	26496610
RT12_HUMAN	MRPS12	physical	26496610
SSRG_HUMAN	SSR3	physical	26496610
UBP1_HUMAN	USP1	physical	26496610
NCOA4_HUMAN	NCOA4	physical	26496610
STX10_HUMAN	STX10	physical	26496610
CEP57_HUMAN	CEP57	physical	26496610
TXN4A_HUMAN	TXNL4A	physical	26496610
HAUS5_HUMAN	HAUS5	physical	26496610
TRM7_HUMAN	FTSJ1	physical	26496610
TRM6_HUMAN	TRMT6	physical	26496610
CK5P2_HUMAN	CDK5RAP2	physical	26496610
TM165_HUMAN	TMEM165	physical	26496610
TRI56_HUMAN	TRIM56	physical	26496610
ATG4A_HUMAN	ATG4A	physical	26496610
INT1_HUMAN	INTS1	physical	26496610

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of UBP43_HUMAN

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"A quantitative atlas of mitotic phosphorylation."; Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1041, AND MASSSPECTROMETRY.	18669648 [Abstract]
"Multiple reaction monitoring for robust quantitative proteomicanalysis of cellular signaling networks."; Wolf-Yadlin A., Hautaniemi S., Lauffenburger D.A., White F.M.; Proc. Natl. Acad. Sci. U.S.A. 104:5860-5865(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-835, AND MASSSPECTROMETRY.	17389395 [Abstract]