TMCC2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: TMCC2_HUMAN
• UniProt AC: O75069
• Protein Name: Transmembrane and coiled-coil domains protein 2
• Gene Name: TMCC2
• Organism: Homo sapiens (Human).
• Sequence Length: 709
• Subcellular Localization: Membrane ; Multi-pass membrane protein . Endoplasmic reticulum .
• Protein Description: May be involved in the regulation of the proteolytic processing of the amyloid precursor protein (APP) possibly also implicating APOE..
• Protein Sequence: MKRCRSDELQQQQGEEDGAGLEDAASHLPGADLRPGETTGANSAGGPTSDAGAAAAPNPGPRSKPPDLKKIQQLSEGSMFGHGLKHLFHSRRRSREREHQTSQDSQQHQQQQGMSDHDSPDEKERSPEMHRVSYAMSLHDLPARPTAFNRVLQQIRSRPSIKRGASLHSSSGGGSSGSSSRRTKSSSLEPQRGSPHLLRKAPQDSSLAAILHQHQCRPRSSSTTDTALLLADGSNVYLLAEEAEGIGDKVDKGDLVALSLPAGHGDTDGPISLDVPDGAPDPQRTKAAIDHLHQKILKITEQIKIEQEARDDNVAEYLKLANNADKQQVSRIKQVFEKKNQKSAQTIAQLHKKLEHYRRRLKEIEQNGPSRQPKDVLRDMQQGLKDVGANVRAGISGFGGGVVEGVKGSLSGLSQATHTAVVSKPREFASLIRNKFGSADNIAHLKDPLEDGPPEEAARALSGSATLVSSPKYGSDDECSSASASSAGAGSNSGAGPGGALGSPKSNALYGAPGNLDALLEELREIKEGQSHLEDSMEDLKTQLQRDYTYMTQCLQEERYRYERLEEQLNDLTELHQNEMTNLKQELASMEEKVAYQSYERARDIQEAVESCLTRVTKLELQQQQQQVVQLEGVENANARALLGKFINVILALMAVLLVFVSTIANFITPLMKTRLRITSTTLLVLVLFLLWKHWDSLTYLLEHVLLPS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
6	Phosphorylation	--MKRCRSDELQQQQ --CCCCCHHHHHHHH	38.78	-
48	Phosphorylation	ANSAGGPTSDAGAAA CCCCCCCCCCCCCCC	42.38	-
49	Phosphorylation	NSAGGPTSDAGAAAA CCCCCCCCCCCCCCC	28.70	-
75	Phosphorylation	LKKIQQLSEGSMFGH HHHHHHHCCCCCHHH	35.26	28348404
78	Phosphorylation	IQQLSEGSMFGHGLK HHHHCCCCCHHHHHH	13.59	28348404
126	Phosphorylation	SPDEKERSPEMHRVS CCCHHHCCHHHHHHH	26.72	26437602
160	Phosphorylation	QQIRSRPSIKRGASL HHHHCCCCCCCCCCC	39.36	29083192
163	Methylation	RSRPSIKRGASLHSS HCCCCCCCCCCCCCC	44.21	-
166	Phosphorylation	PSIKRGASLHSSSGG CCCCCCCCCCCCCCC	29.46	29083192
169	Phosphorylation	KRGASLHSSSGGGSS CCCCCCCCCCCCCCC	31.34	29083192
170	Phosphorylation	RGASLHSSSGGGSSG CCCCCCCCCCCCCCC	23.43	29083192
171	Phosphorylation	GASLHSSSGGGSSGS CCCCCCCCCCCCCCC	44.46	29083192
175	Phosphorylation	HSSSGGGSSGSSSRR CCCCCCCCCCCCCCC	34.50	29083192
176	Phosphorylation	SSSGGGSSGSSSRRT CCCCCCCCCCCCCCC	46.07	29083192
178	Phosphorylation	SGGGSSGSSSRRTKS CCCCCCCCCCCCCCC	27.39	29083192
179	Phosphorylation	GGGSSGSSSRRTKSS CCCCCCCCCCCCCCC	31.24	29083192
180	Phosphorylation	GGSSGSSSRRTKSSS CCCCCCCCCCCCCCC	27.72	29083192
185	Phosphorylation	SSSRRTKSSSLEPQR CCCCCCCCCCCCCCC	25.25	27080861
186	Phosphorylation	SSRRTKSSSLEPQRG CCCCCCCCCCCCCCC	40.26	27080861
194	Phosphorylation	SLEPQRGSPHLLRKA CCCCCCCCCCHHHHC	16.01	25307156
226	Phosphorylation	RSSSTTDTALLLADG CCCCCCCEEEEECCC	19.67	-
330	Phosphorylation	NADKQQVSRIKQVFE CCCHHHHHHHHHHHH	24.77	19664994
409	Phosphorylation	VVEGVKGSLSGLSQA HHCCCCCHHCCCCCC	17.40	24719451
419	Phosphorylation	GLSQATHTAVVSKPR CCCCCCEEEHHCCHH	19.45	24719451
423	Phosphorylation	ATHTAVVSKPREFAS CCEEEHHCCHHHHHH	30.28	24719451
438	Phosphorylation	LIRNKFGSADNIAHL HHHHHHCCCCCCCCC	35.27	29255136
446	Acetylation	ADNIAHLKDPLEDGP CCCCCCCCCCCCCCC	47.64	7661759
462	Phosphorylation	EEAARALSGSATLVS HHHHHHHCCCEEEEE	29.71	30266825
464	Phosphorylation	AARALSGSATLVSSP HHHHHCCCEEEEECC	18.07	30266825
466	Phosphorylation	RALSGSATLVSSPKY HHHCCCEEEEECCCC	29.41	30266825
469	Phosphorylation	SGSATLVSSPKYGSD CCCEEEEECCCCCCC	43.99	30266825
470	Phosphorylation	GSATLVSSPKYGSDD CCEEEEECCCCCCCC	20.24	15345747
473	Phosphorylation	TLVSSPKYGSDDECS EEEECCCCCCCCCCC	25.83	25072903
475	Phosphorylation	VSSPKYGSDDECSSA EECCCCCCCCCCCCC	38.51	25072903
480	Phosphorylation	YGSDDECSSASASSA CCCCCCCCCCCHHHC	27.22	25072903
481	Phosphorylation	GSDDECSSASASSAG CCCCCCCCCCHHHCC	37.59	25072903
483	Phosphorylation	DDECSSASASSAGAG CCCCCCCCHHHCCCC	30.54	25072903
485	Phosphorylation	ECSSASASSAGAGSN CCCCCCHHHCCCCCC	20.44	25072903
486	Phosphorylation	CSSASASSAGAGSNS CCCCCHHHCCCCCCC	30.36	25072903
491	Phosphorylation	ASSAGAGSNSGAGPG HHHCCCCCCCCCCCC	27.56	25072903
493	Phosphorylation	SAGAGSNSGAGPGGA HCCCCCCCCCCCCCC	31.55	25072903
503	Phosphorylation	GPGGALGSPKSNALY CCCCCCCCCCCCCCC	29.97	25072903
581	Phosphorylation	ELHQNEMTNLKQELA HHHHHHHHHHHHHHH	31.08	-
589	Phosphorylation	NLKQELASMEEKVAY HHHHHHHHHHHHHHH	39.07	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of TMCC2_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of TMCC2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of TMCC2_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
A4_HUMAN	APP	physical	21832049
TMCC2_HUMAN	TMCC2	physical	25416956
KAT5_HUMAN	KAT5	physical	25416956
DIP2A_HUMAN	DIP2A	physical	25416956
PRP31_HUMAN	PRPF31	physical	25416956
AMOL2_HUMAN	AMOTL2	physical	25416956
ZN581_HUMAN	ZNF581	physical	25416956
F90A1_HUMAN	FAM90A1	physical	25416956
ZN250_HUMAN	ZNF250	physical	25416956
CCD33_HUMAN	CCDC33	physical	25416956
F161A_HUMAN	FAM161A	physical	25416956
RHXF2_HUMAN	RHOXF2	physical	25416956
DPY30_HUMAN	DPY30	physical	25416956
ZN587_HUMAN	ZNF587	physical	25416956
FBF1_HUMAN	FBF1	physical	25416956
ZN417_HUMAN	ZNF417	physical	25416956
CF206_HUMAN	C6orf165	physical	25416956
IQUB_HUMAN	IQUB	physical	25416956
FBLI1_HUMAN	FBLIM1	physical	28514442
MARK2_HUMAN	MARK2	physical	28514442
MARK3_HUMAN	MARK3	physical	28514442
UHRF1_HUMAN	UHRF1	physical	28514442
ACTBL_HUMAN	ACTBL2	physical	28514442
HNRLL_HUMAN	HNRNPLL	physical	28514442
ACTB_HUMAN	ACTB	physical	28514442
CMTR1_HUMAN	CMTR1	physical	28514442
COR1A_HUMAN	CORO1A	physical	28514442
FKB10_HUMAN	FKBP10	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.